Department of
Obstetrics and Gynecology

UNIVERSITY OF WISCONSIN
SCHOOL OF MEDICINE AND PUBLIC HEALTH
Protrait

Derek Boeldt, PhD
Assistant Professor
Reproductive Sciences


dsboeldt@wisc.edu
Office Address
Meriter Hospital
202 S. Park (Meriter)
Madison, WI, 53715


Administrative Assistant
Cindy Goss
cgoss@wisc.edu
608-417-6314

Education

B.S. University of Wisconsin-Madison, Madison, WI
PhD University of Wisconsin-Madison, Madison, WI

Honors and Awards

UW–Madison Dept. Ob-Gyn – Douglas W. Laube Best Trainee Paper Award
 
Perinatal Research Society – Associate Member Best Paper Award (Basic Science Track)
 
UW–Madison Dept. Ob-Gyn – Chester B. Martin Graduate Training Program Mentorship Award
 
Top Downloaded Authors – Journal of Endocrinology: “Vascular adaptationin pregnancy and endothelial dysfunction in preeclampsia”
 
Most Cited Papers – Journal of Endocrinology (Impact factor 4.012): “Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia”
 
Most Cited Papers – Journal of Endocrinology (Impact factor 4.012): “Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia”
 
Accepted to and participated in Early Career Reviewer Program – PN Study Section NICHD


Memberships

Member – Integrated Program in Endocrinology (IPEnd) 

Full Member – Society for Reproductive Investigation


Boeldt Lab research

Research in the Boeldt Lab is focused on development of new therapies for preeclampsia, a pregnancy-related disorder characterized by high blood pressure, kidney and liver dysfunction, and often small and premature babies. Preeclampsia affects 3-5% of pregnancies in the United States and to date, there is no effective treatment.

Our research is primarily interested in how to target endothelial cells with new or existing drugs to combat the symptoms of preeclampsia. Endothelial cells are the single cell layer that lines the inside of blood vessels and largely dictates blood vessel function and are widely known to behave abnormally in preeclamptic pregnancies. There are a number of ways that endothelial cells may be driven to behave abnormally in preeclampsia.

We are investigating how an over-activated immune system may be 1) directly interacting with the endothelial cells to cause inflammation and endothelial dysfunction, or 2) indirectly through increased cytokine release, causing endothelial cell confusion and abnormal function. Understanding how these processes are occurring during preeclamptic pregnancies will help us design drugs to precisely target the cause of and progression of preeclampsia.


OBS&GYN 710 - Reproductive Endocrine Physiology

Fall Semester

Course Director

Fundamental Endocrinology I & II, Lactation, Barker Hypothesis I & II, Pathophysiology of Preeclampsia, Endocrine Disruptors, Case Studies

OBS&GYN 711 - Advanced Reproductive Endocrine Physiology

Spring - Odd years

Comparative Placentation and Placental Endocrinology

Grand Rounds: Department Research Day

On May 13, 2021, the UW Department of Obstetrics and Gynecology hosted Department Research Day, featuring exceptional presentations on fundamental, clinical, and quality improvement research. Recorded presentations from Department Research Day are available now.

To start the morning, Kimberly Gregory, MD, MPH of Cedars-Sinai Obstetrics and Gynecology Department presented the keynote lecture “Patient Reported Outcomes in Ob/Gyn: What are they? Who Cares? And Why?”.

In the lecture, Gregory differentiated between three measures of patient outcomes, outlined types of patient-reported outcomes used in ob-gyn clinical care, and described how these measures can drive quality improvement efforts.

Other presentations at Department Research Day included:

“Bone Loss and Osteoporosis Risk in Younger Gynecologic Cancer Patients”, presented by graduating gynecologic oncology fellow Janelle Sobecki, MD, MA

“Connecting the Dots: The Role of Endothelial-Immune Interaction in the Pathophysiology of Preeclampsia”, presented by Derek Boeldt, PhD, of the Division of Reproductive Sciences

“Post-Cesarean Pain”, presented by Katie Antony, MD, of the Division of Maternal-Fetal Medicine

You can watch the lectures from Department Research Day here.