Protrait

 

Ted Golos, PhD
Professor
Chair, Department of Comparative Biosciences
Professor, Department of Obstetrics and Gynecology


Reproductive Sciences


Office Address
Wisconsin National Primate Research Center
Southwest Commuter Path
Madison, WI, 53715


Education

B.S. Biology, Marquette University, Milwaukee, WI

M.S. Physiology and Biophysics, University of Illinois - Urbana, Urbana, IL

Ph.D. Physiology and Biophysics, University of Illinois - Urbana, Urbana, IL

Postdoctoral Fellow Department of Obstetrics and Gynecology, Division of Reproductive Biology, University of Pennsylvania, Philadelphia, PA


Service Activities

2019   Member, NIH Study Section, NIAID RFA Study Section "Immune Mechanisms at the Maternal-Fetal Interface"


Honors and Awards

2019    Vilas Distinguished Achievement Professor, UW-Madison 

2015    Zoetis Award for Veterinary Research Excellence     


Memberships

American Society for Reproductice Immunology

Society for Gynecologic Investigation

International Federation of Placental Associations

Society for the Study of Reproduction

Golos Lab Research Interests

Regulation of Trophoblast and Stem Cell Differentiation

Maternal-Fetal Immune Interactions

Mechanisms of Embryo Implantation and Placental Morphogenesis

Primate Tansgenesis and Genomic Editing

Reproductive Tract Infection, Inflammation and Pregnancy Loss


Golos Laboratory Research

The Golos Laboratory examines questions of placental biology relevant to human health and disease, using nonhuman primate models, human clinical materials, and human and nonhuman primate embryonic stem cells in their studies. Study of the maternal-fetal immune dialogue examines nonpolymorphic MHC class I molecules expressed on placental cells and their interactions with the maternal immune system, particularly endometrial natural killer cells and macrophages in promoting pregnancy success, including placental and decidual vascularization. In addition, embryonic stem cells and primate embryos are used to model implantation and placental morphogenesis, with 2-dimensional and 3-dimensional modeling and co-culture systems for understanding how placental cells carry on a dialog with the maternal endometrium. At the interface of these projects is the effect of maternal immune cells directly on rhesus blastocyst function and growth in 3-dimensional co-culture.

Maternal immune recognition of pregnancy, and regulation of a healthy implantation site and placenta, may play a significant role in pregnancy issues ranging from miscarriage and recurrent pregnancy loss to preeclampsia and intrauterine growth restriction. The primate model will allow direct experimentation at the maternal-fetal interface to develop experimental and therapeutic models of utero-placental function and dysfunction.


Great updates from the Golos Lab!

Some very exciting accomplishments out of the Division of Reproductive Sciences’ Golos Lab in recent weeks!

Sydney Nguyen, PhD trainee in the Golos Lab and UW-Madison Endocrinology and Reproductive Physiology program, will soon publish the paper Impact of Ferumoxytol Magnetic Resonance Imaging on the Rhesus Macaque Maternal-Fetal Interface" in Biology of ReproductionNguyen, recipient of the 2019 Ob-Gyn Douglas Laube Best Graduate Trainee Award, was first author; Ted Golos, PhD, is senior author; and Human Placenta Project co-PI Dinesh Shah, MD is also a co-author.   

Nguyen, as well as Golos Lab trainee Bryce Wolfewere UW-Madison nominees for the Schmidt Science Fellows award, an international competition for cross-disciplinary postdoctoral fellowships.

Jenna Kropp Schmidt, PhD, earned an NIH K99 Pathways to Independence award entitled "Primate-specific miRNAs in Embryonic and Placental Development.” Ted Golos, PhD is the primary mentor, and Aleks Stanic, MD, PhD is on the mentor team.

And last but not least, Golos was named a Vilas Distinguished Achievement Professor by the UW-Madison Office of the Provost. 

Congratulations, all!


Golos receives Vilas Distinguished Achievement Professorship

Huge congratulations to Ted Golos, PhD, of the UW Ob-Gyn Division of Reproductive Sciences! Golos earned the 2020 UW-Madison Vilas Distinguished Achievement Professorshipan award recognizing distinguished scholarship as well as standout efforts in teaching and service. 

The Vilas Distinguished Achievement Professorship provides five years of flexible funding — two-thirds of which is provided by the Office of the Provost through the generosity of the Vilas trustees and one-third provided by the school or college whose dean nominated the winner. Golos is one of only sevel professors to receive the award this year.

Congratulations, Dr. Golos, on this well-deserved honor!


Golos earns UW ICTR Translational Basic and Clinical pilot award

Ted Golos, PhD, of the UW Ob-Gyn Division of Reproductive Sciences, received a Translational Basic and Clinical pilot award from the UW-Madison Institute for Clinical and Translational ResearchKatie Antony, MD, of the UW Ob-Gyn Division of Maternal-Fetal Medicine, is a collaborator on the grant.

Nonhuman Primate Placental Therapy” will build on information learned from the NICHD’s Human Placenta Project – researchers will “uniquely demonstrate the feasibility of using placenta-targeted nanoparticles with primate maternal-fetal interface specificity.”

Congratulations, Dr. Golos!


Golos research offers new way to study HIV therapies

New research from Ted Golos, PhD, of the UW Ob-Gyn Division of Reproductive Sciences, may provide an important animal model to study HIV therapies that could apply to humans.

The study “Genome editing of CCR5 by CRISPR-Cas9 in Mauritian cynomolgus macaque embryos”, published in Scientific Reports, outlines the research team’s methods for editing the DNA in cynomolgus macaque monkey embryos using CRISPR:

Nonhuman primates, and more specifically macaques, serve as important model species to study HIV-1 through infection with simian immunodeficiency virus (SIV). SIV infected animals show similar elements of human HIV-1 infection including immune responses and pathogenesis, and additionally, tissues are more accessible for study compared to human studies. Mauritian cynomolgus macaques (MCMs) offer a distinct advantage over other macaque species as they have only seven major histocompatibility complex (MHC) haplotypes allowing for the study of defined immune responses and to control genetic factors in the setting of allogeneic bone marrow transplant. This provides a powerful means for quantifying the effect of MHC matching on the capacity of allogeneic cells to purge the SIV reservoir.”

Read this excellent overview of the discovery from UW-Madison News, and read the whole journal article here.


Lindsey Block, of Golos Lab, published in Biology of Reproduction

Lindsey Block, graduate student in the Golos Lab, is first author on a recent paper in the journal Biology of Reproduction entitled “The promise of placental extracellular vesicles: models and challenges for diagnosing placental dysfunction in utero”.

Co-authors include Aleks Stanic, MD, PhD, of the UW Ob-Gyn Divisions of Reproductive Endocrinology and Infertility and Reproductive Sciences, and Ted Golos, PhD, of the Division of Reproductive Sciences.  

Block’s paper was featured in the Weekly News email from the Society for the Study of Reproduction. Read the whole article here. Congratulations to the publication team!