Role of Endogenous AhR Ligand in Pregnancy

Sponsor(s): NCATS/NIH

The goal of this project is to determine the role of AhR ligands in vascular development and function during pregnancy.

---

The role of miRNAs in placental vascular function

The goal of this project is to determine the role of miRNAs in controlling fetoplacental vascular function.

---

Vascular function in pregnancy

---

Zheng earns Editor’s Choice distinction in Journal of Physiology

Congratulations to Jing Zheng, PhD, professor in the Division of Reproductive Sciences, whose recent article was selected as the Editor’s Choice in the August issue of The Journal of Physiology! Zheng is senior author on the article; Chi Zhou, PhD, former postdoctoral trainee in the Department of Ob-Gyn and current assistant professor at the University of Arizona, is the first author.

In “MicroRNA-29 differentially mediates preeclampsia-dysregulated cellular responses to cytokines in female and male fetal endothelial cells”, Zheng, Zhou and co-authors reveal fetal sex-specific dysregulation of target genes of two microRNAs in fetal endothelial cells from preeclampsia. This differential dysregulation may contribute to fetal sex-specific endothelial dysfunction in offspring born to preeclamptic mothers.

Read the whole article here. Incredible work Dr. Zheng, Dr. Zhou, and team!

---

Zheng, Zhou publish in Journal of Physiology

Jing Zheng, PhD, professor in the UW Ob-Gyn Division of Reproductive Sciences, recently published an article in the Journal of Physiology entitled “MicroRNA-29 differentially mediates preeclampsia-dysregulated cellular responses to cytokines in female and male fetal endothelial cells.” Chi Zhou, PhD, a formal member of Division of Reproductive Sciences, is the first author and co-correspondence. 

In the article, Zheng, Zhou and co-authors reveal fetal sex-specific dysregulation of target genes of two microRNAs in fetal endothelial cells from preeclampsia. This differential dysregulation may contribute to fetal sex-specific endothelial dysfunction in offspring born to preeclamptic mothers.

Read the whole article here.

---

Division of Reproductive Sciences prepares impressive slate of research for Society for Reproductive Investigation conference

The 2022 Society for Reproductive Investigation’s Annual Scientific Meeting, held in Denver, CO between March 15-19, features several presentations, posters and abstracts from members of the UW Ob-Gyn Division of Reproductive Sciences! Just some of their exciting accomplishments:

Clinical and Translational Perinatology Oral Presentation:

Breastfeeding Promotes Predominant Bifidobacterium in Farm-Exposed Infants
Deborah Chasman, Krittisak Chaiyakul, Samantha Fye, James E Gern, Susan V Lynch, Christine M Seroogy, Irene M Ong

Maternal Biology and Health oral presentation:

Perfluorooctane Sulfonic Acid (PFOS) Increases Mean Arterial Pressure by Impairing Endothelial Nitric Oxide-Mediated Vasodilation and Enhancing Angiotensin II-Mediated Vascular Contraction in Pregnant Rats
Sri V Dangudubiyyam, Jay S Mishra, Ruolin Song, Sathish Kumar

Preeclampsia oral presentation:

Preeclampsia Differentially Dysregulates Female and Male Fetal Endothelial Cells Function and Transcriptomic Profiles in Lean and Obese Pregnancies.
Chi Zhou, Allison Yang, Colman Freel, Olivia Mills, Jing Zheng

Preeclampsia II Oral Presentation session, moderated by Aishwarya Rengarajan

Abstracts:

An Endogenous Aryl Hydrocarbon Receptor Ligand Induces Preeclamptic Phenotypes in Rats. Ying-jie Zhao, Chi Zhou, Hui-hui Li, Jay S Mishra, Sathish Kumar, Jing Zheng

Follicular Immune Signature of Polycystic Ovarian Syndrome in Women Undergoing Infertility Treatment. Soma Banerjee, Fernanda B Levya Jaimes, Abigail A Zettel, Eryne T Jenkins, Jason Austin, Laura G Cooney, Aleksander K Stanic

Immunohistochemical Localization of ACE2 in the Male Reproductive Tract in the Rhesus Macaque: Implications for Nonhuman Primate Model Development for COVID-19. Hayly Hinkle, Sierra Block, Ann Mitzey, Jenna Schmidt, Gregory Wiepz, Thaddeus G. Golos

Estradiol Protects Against Gestational Intermittent Hypoxia-Induced Hypertension and Metabolic Dysfunctions in the Adult Female Offspring. Ruolin Song, Jay S Mishra, Sri V Dangudubiyyam, Jyoti Watters, Tracy Baker, Sathish Kumar

Novel Role of Angiotensin Type 2 Receptor in Promoting Angiogenesis in Primary Human Uterine Artery Endothelial Cells. Jay S Mishra, Sri V Dangudubiyyam, Ruolin Song, Dong-Bao Chen, Sathish Kumar

Endothelial Dysfunction in Preeclampsia: The Story of the Interleukins. Rachel L Dahn, Amanda C Ampey, Jason L Austin, Ian M Bird

Congratulations to all!

---