David Abbott, PhD, of the UW Ob-Gyn Division of Reproductive Sciences, co-edited a recent issue of the journal Current Opinion in Endocrine and Metabolic Research focused on polycystic ovary syndrome! Abbott also co-authored the leading editorial in the issue: “Polycystic ovary syndrome inspires clinical consensus and scientific innovation.”
The issue includes articles on clinical and research advances in PCOS diagnosis and treatment, as well as advances in our understanding of the genetic component of PCOS. In addition to editing and authoring the leading editorial, Abbott also co-authored the article “Endocrine–metabolic dysfunction in polycystic ovary syndrome: an evolutionary perspective”:
“Adipose dysfunction in PCOS from hyperandrogenemia and hyperinsulinemia likely constrains subcutaneous fat storage, promoting lipotoxicity through ectopic lipid accumulation and oxidative stress, insulin resistance, and inflammation in nonadipose tissue. Recent findings of inherently exaggerated subcutaneous abdominal stem cell development to adipocytes in women with PCOS, and PCOS-like traits in adult female monkeys with natural hyperandrogenemia, imply common ancestral origins of PCOS in both human and nonhuman primates.”
Read the whole issue, which has generated a lot of appreciative feedback. Incredible work, Dr Abbott!