“TNF-alpha inhibits pregnancy-adapted Ca2+ signaling in uterine artery endothelial cells” was authored by Amanda C. Ampey, PhD (alum of UW ERP); Derek S. Boeldt, PhD, of the UW Ob-Gyn Division of Reproductive Sciences; Luca Clemente, PhD (alum of UW ERP); Mary A. Grummer, of the UW Ob-Gyn Division of Reproductive Sciences; FuXian Yi, of the UW Ob-Gyn Division of Reproductive Sciences; Ronald R. Magness; and Dr. Bird.
The study significantly increases the field’s understanding of basic cellular and molecular signaling, hopefully opening the door to therapeutics for patients experiencing preeclampsia:
“There are many questions still to answer, but the major findings of this study are the clear demonstration that TNF-alpha can indeed mediate endothelial damage acutely through Cx43 inhibitory phosphorylation (rather than through excess ROS production), and at physiologically relevant doses. The results suggest that longer treatment at physiologic levels of TNF-alpha seen in PE subjects may explain the observed loss of vasodilatory function in PE subjects.”
Read the whole study here. Congratulations to all involved!