“Identification of unique clusters of T, dendritic, and innate lymphoid cells in the peritoneal fluid of ovarian cancer patients” is a collaboration between members of the Patankar Lab and Stanic Lab, with clinical collaborators in the Division of Gynecologic Oncology. Co-authors include Division of Reproductive Sciences Director Manish Patankar, PhD, Aleks Stanic-Kostic, MD, PhD, Stanic Lab postdoctoral fellow Jessica Vazquez, PhD, Patankar Lab assistant scientist Arvinder Kapur, PhD, gynecologic oncologist Lisa Barroilhet, MD, and recently graduated resident Antonio Romo de Vivar Chavez, MD.
This work focuses on determination of the immune compartment in ovarian cancer ascites, an understudied but extremely important site for immune control of cancer spread. For the study, the Stanic Lab used their advanced immune monitoring platform using high-dimensional flow cytometry to examine the immunome of ascites specimens isolated, processed, characterized and cryopreserved by the Patankar Lab. Researchers identified novel immune cell clusters and demonstrated their association with pre-surgery CA-125 level, hinting at modulation of subsequent survival.
This work forms the basis of several projects and grant applications from Patankar and Stanic Labs and exemplifies the collaborative spirit of the Divisions of Reproductive Sciences and Gynecologic Oncology.
Read the whole article here – congratulations to all co-authors!