“Oxidative stress induced by the anti-cancer agents, plumbagin, and atovaquone, inhibits ion transport through Na+/K+-ATPase” was written in collaboration with Patankar, Bikash Pattnaik, PhD, of the UW SMPH Department of Pediatrics, Lisa Barroilhet, MD, of the UW Ob-Gyn Division of Gynecologic Oncology, and Arvinder Kapur, of the UW Ob-Gyn Division of Reproductive Sciences.
In the study, Alharbi and co-authors found that plumbagin inhibits proliferation of human and mouse ovarian cancer cells:
“Recently we demonstrated that plumbagin was an effective anti-cancer agent and that its cytotoxic effect could be demonstrated across multiple cancer cell lines. Here, we extend these previous observations to further confirm the cytolytic activity of plumbagin against mouse (ID8) and human (SKOV-3, OVCAR-3, and TYKNu) high grade serous ovarian cancer cell lines. Our data demonstrate that irrespective of the cell line used, plumbagin was able to inhibit proliferation at an IC50 between 2.5 and 10 µM.”
Read the whole article here – congratulations to the research team!