Schmuhl authors article on HPV vaccination and infertility in Vaccine

Tags: Nicholas Schmuhl, reproductive and population health, reproductive endocrinology and infertility, publication, research, Laura Cooney

Nicholas Schmuhl, PhD, of the UW Ob-Gyn Division of Reproductive and Population Health, is lead author on a new publication in the journal Vaccine! 

No association between HPV vaccination and infertility in U.S. females 18–33 years old used data from the 2013–2016 National Health and Nutrition Examination Survey to assess likelihood of self-reported infertility among women in the age range to have been able to get the HPV vaccine and be queried about fertility concerns.

While the HPV vaccine helps prevent many HPV-related cancers in men and women, HPV vaccination rates fall short of other recommended adolescent immunizations. At the same time, (retracted) publications and anecdotes in popular media have given rise to concerns that HPV vaccination may contribute to lowered fertility.

Schmuhl and co-authors (including Laura Cooney, MD, of the UW Ob-Gyn Division of Reproductive Endocrinology and Infertility) found no evidence of increased infertility among women who received the HPV vaccine. They used two models:

“Two logistic regression models, stratified by marital history, examined potential associations between HPV vaccination and infertility. Model 1 assessed the likelihood of infertility among women who had never been pregnant or whose pregnancies occurred prior to HPV vaccination. Model 2 accounted for the possibility of latent and/or non-permanent post-vaccine infertility by including all women 20–33 years old who reported any 12-month period of infertility.”

Neither model revealed any association between HPV vaccination at any age and self-reported infertility, regardless of marital status.

Read the whole article here!