“Transcriptional and Functional Programming of Decidual Innate Lymphoid Cells” is a study spearheaded by lead author Jessica Vazquez, PhD, a post-doctoral fellow in the Stanic Lab, and was a joint effort with Deborah Chasman, PhD (Irene Ong lab) and Chanel Tyler, MD (MFM).
It focuses on the discovery of novel innate immune cells in the decidua in human pregnancy at term identified by Vazquez and colleagues. Detailed analysis – using a multitude of advanced single cell technologies over three years of laboratory work – demonstrates functional properties associated with pregnancy success (secretion of cytokines/factors associated with angiogenesis, vascular remodeling).
Analysis, in collaboration with the Ong Lab, also reveals continuity of these cell types at term pregnancy with those identified in first trimester decidua by a large sequencing consortium in England. This work is an example of collaborative studies between basic/translational scientists, clinicians and computational scientists in our department that drive pregnancy research forward.
You can read the whole manuscript here. Incredible work by everyone involved!