Jing Zheng, PhD, of the UW Ob-Gyn Division of Reproductive Sciences recently published an article in the journal Hypertension entitled “Sexual Dimorphisms of Preeclampsia-Dysregulated Transcriptomic Profiles and Cell Function in Fetal Endothelial Cells”. Chi Zhou, PhD, of the Division of Reproductive Sciences is the first author. UW Ob-Gyn Reproductive Sciences Division Director Ian Bird, PhD, and Chanel Tyler, MD, of the UW Ob-Gyn Division of Maternal-Fetal Medicine, also co-authored the article.
In this article, they reveal that preeclampsia differentially dysregulates cardiovascular diseases- and endothelial function-related genes in association with differentially dysregulated endothelial function in male and female fetal endothelial cells from preeclampsia. These sexual dimorphisms of preeclampsia-dysregulated fetal endothelial genes may be used as sex-specific risk predictors for adult-onset cardiovascular diseases in offspring born to preeclampsia, as pointed out by an accompanying editorial commentary written by Jane F. Reckelhoff et al.