Zheng publishes in Hypertension

Tags: research, publication, maternal-fetal medicine, reproductive sciences

Jing Zheng, PhD, of the UW Ob-Gyn Division of Reproductive Sciences recently published an article in the journal Hypertension entitled “Sexual Dimorphisms of Preeclampsia-Dysregulated Transcriptomic Profiles and Cell Function in Fetal Endothelial Cells”. Chi Zhou, PhD, of the Division of Reproductive Sciences is the first author.  UW Ob-Gyn Reproductive Sciences Division Director Ian Bird, PhD, and Chanel Tyler, MD, of the UW Ob-Gyn Division of Maternal-Fetal Medicine, also co-authored the article.

In this article, they reveal that preeclampsia differentially dysregulates cardiovascular diseases- and endothelial function-related genes in association with differentially dysregulated endothelial function in male and female fetal endothelial cells from preeclampsia.  These sexual dimorphisms of preeclampsia-dysregulated fetal endothelial genes may be used as sex-specific risk predictors for adult-onset cardiovascular diseases in offspring born to preeclampsia, as pointed out by an accompanying editorial commentary written by Jane F. Reckelhoff et al. 

Be sure to read the whole article and the editorial commentary.  Congratulations to all the authors!