Wegrzynowicz publishes in Biology of Reproduction

Andrea Wegrzynowicz, PhD, postdoctoral trainee in the Division of Reproductive Sciences and the Stanic Lab, is lead author on a new study in Biology of Reproduction that was featured as a BoR Editor’s Choice article in the Society for the Study of Reproduction monthly newsletter! Co-authors on the study include Soma Banerjee, Emily Grimes, Riley Huddleston, Fernanda Leyva Jaimes, Laura Cooney, MD, and Aleksandar Stanic, MD, PhD. 

In the paper “Single-cell analysis of follicular fluid reveals dysregulation of ovulatory immune function in Polycystic Ovary Syndrome patients undergoing ovarian stimulation”, Wegrzynowicz and colleagues find that: 

“...despite ovulation induction, the ovarian follicular environment in patients with Polycystic Ovary Syndrome remains immunologically dysregulated. Unlike healthy follicles, PCOS follicles show impaired ovulatory immune signaling and a persistent low-grade inflammatory state, highlighting ongoing local dysfunction.” 

Read the whole study here!