Portrait of Laurel W. Rice
Laurel W. Rice, MD
Emeritus, Retired Chair and Emeritus Professor
UW Hospital and Clinics

Laurel W. Rice is a Retired Chair of the Department of Obstetrics and Gynecology and an Emeritus Professor in the Division of Gynecologic Oncology at the University of Wisconsin-Madison School of Medicine and Public Health.

Dr. Rice attended college and medical school at the University of Colorado. She completed her residency in Obstetrics and Gynecology as well as a Fellowship in Gynecologic Oncology at the Brigham and Women’s Hospital, an affiliate of Harvard Medical School in Boston, MA. After four years on the faculty of Massachusetts General Hospital, the University of Virginia (UVA) recruited her to the Department of Obstetrics and Gynecology. During her 14 years at UVA, Dr. Rice was appointed Division Chief of Gynecologic Oncology, established a Fellowship in Gynecologic Oncology, and served as Vice Chair of the Department of Obstetrics and Gynecology.

Nationally recognized as an expert in the care of women with gynecologic malignancies, Dr. Rice has published extensively in her field. Her present research focuses on health disparities. She has lectured extensively throughout the United States.

Dr. Rice continues to serve in leadership positions of many national organizations. She is Immediate Past President of the American Gynecological & Obstetrical Society, Past President of the Society of Gynecologic Oncology, Past President of the Council of University Chairs of Obstetrics and Gynecology, and an active member of several other professional organizations.

Since 2006, Dr. Rice has served on the American Board of Obstetrics and Gynecology and currently serves as a Representative on the Board of Directors. Additionally, she is currently serving a four-year term as Treasurer. She is also an examiner for candidates seeking board certification in both General Obstetrics and Gynecology, in addition to the subspecialty area of Gynecologic Oncology.

Dr. Rice also serves as Deputy Editor of Gynecologic Oncology and as a reviewer for Obstetrics and Gynecology and the American Journal of Obstetrics and Gynecology, both highly regarded journals in her field.

Fellowship Gynecologic Oncology Brigham and Women’s Hospital, Boston, MA 1987-1989
Residency Obstetrics and Gynecology Brigham and Women’s Hospital, Boston, MA 1983-1987
MD Doctor of Medicine University of Colorado School of Medicine, Denver, Colorado 1983
BS Pharmacy University of Colorado, Boulder, Colorado 1979

1990 American Board of Obstetrics and Gynecology, Obstetrics and Gynecology

1991 American Board of Obstetrics and Gynecology, Gynecologic Oncology

Retired Department Chair, Obstetrics and Gynecology

2019 Best Doctors in America-Best Doctors, Inc.

2018 Madison’s Top Doctors 2018, Madison Magazine

2018 CURE® Magazine’s 2018 Ovarian Cancer Hero

2016 Guest Speaker, White Coat Ceremony, University of Wisconsin-Madison

2016 Best Doctors in America-Best Doctors, Inc.

2015 Best Doctors in America-Best Doctors, Inc.

American Board of Obstetrics and Gynecology

American College of Obstetricians and Gynecologists

American College of Surgeons

American Gynecological and Obstetrical Society

American Gynecological Club

Association of Professors of Gynecology and Obstetrics, Council on Resident Education in Obstetrics and Gynecology

Council of University Chairs of Obstetrics and Gynecology

Foundation for Women’s Cancer

International Gynecologic Cancer Society

Society for Reproductive Investigation

Society of Family Planning

Society of Gynecologic Oncology

Trends in public- and industry-funded uterine cancer clinical trials and disability-adjusted life years from 2007 to 2019

Connor C Wang, Shannon K Rush, Shitanshu Uppal, Laurel W Rice, Ryan J Spencer

No abstract

Published: 06/20/2022

American journal of obstetrics and gynecology pmid:35724760

Racial and ethnic enrollment disparities in clinical trials of poly(ADP-ribose) polymerase inhibitors for gynecologic cancers

Matthew K Wagar, Rachel P Mojdehbakhsh, Amy Godecker, Laurel W Rice, Lisa Barroilhet

CONCLUSIONS: NH-Black and Hispanic patients are significantly underrepresented in clinical trials evaluating PARP inhibitors for ovarian cancers compared to NH-White cohorts. Phase II/III trials assessing PARP inhibitors for ovarian cancers do not accurately represent the populations diagnosed with these malignancies. Enrollment strategies are needed to increase diversity in PARP inhibitor clinical trials for women's cancers.

Published: 02/11/2022

Gynecologic oncology pmid:35144798

Discrepancies Created by Surgeon Self-Reported Operative Time and the Effects on Procedural Relative Value Units and Reimbursement

Shitanshu Uppal, Laurel W Rice, Ryan J Spencer

CONCLUSION: Despite reliable electronic records, the AMA-RUC continues to use inaccurate self-reported RUC surveys for operative times. This results in discrepancies in RVU per hour (and subsequent reimbursement) across specialties and a persistent disparity for women-specific procedures in gynecology. Relative value unit levels should be based on the available objective data to eliminate these disparities.

Published: 07/08/2021

Obstetrics and gynecology pmid:34237766

Physician attitudes about abortion and their willingness to consult in abortion care at a Midwestern academic medical center

Nicholas B Schmuhl, Laurel W Rice, Cynthia K Wautlet, Jenny A Higgins

CONCLUSION: Most physicians at our center reported support for abortion; however, those who perceived less support among peers reported less willingness to consult in abortion-related care, regardless of specialty.

Published: 05/13/2021

Contraception pmid:33984323

Bone health and osteoporosis screening in gynecologic cancer survivors

Janelle N Sobecki, Laurel W Rice, Ellen M Hartenbach

Cancer treatment-induced bone loss is a known side effect of cancer therapy that increases the risk of osteoporosis and bone fracture. Women with gynecologic cancer are at increased risk of bone loss secondary to the combined effect of oophorectomy and adjuvant therapies. Data regarding bone loss in women with gynecologic cancers are overall lacking compared to other cancer populations. Consequently, guidelines for osteoporosis screening in women with cancer are largely based on data generated...

Published: 12/14/2020

Gynecologic oncology pmid:33309416

The Importance of Physician Concern and Expertise in Increasing Abortion Health Care Access in Local Contexts

Jenny A Higgins, Nicholas B Schmuhl, Cynthie K Wautlet, Laurel W Rice

No abstract

Published: 10/22/2020

American journal of public health pmid:33090878

Increasing NIH funding for academic departments of obstetrics and gynecology: a call to action

Laurel W Rice, Marcelle I Cedars, Yoel Sadovsky, Nazema Y Siddiqui, Stephanie B Teal, Jason D Wright, Andrea Zorbas, Marcela G Del Carmen

The National Institutes of Health funding for reproductive sciences research, specifically in academic departments of obstetrics and gynecology, is disproportionately low. Research is one of the most important pillars in advancing healthcare. Despite US Congress' vision in providing increased funding to the National Institutes of Health as a whole, underfunding for research in the departments of obstetrics and gynecology remains one of the several critical drivers in the decline in reproductive...

Published: 04/10/2020

American journal of obstetrics and gynecology pmid:32272090

Universal access to contraception: women, families, and communities benefit

Laurel W Rice, Eve Espey, Dee E Fenner, Kimberly D Gregory, Jacquelyn Askins, Charles J Lockwood

Universal access to contraception benefits society: unintended pregnancies, maternal mortality, preterm birth, abortions, and obesity would be reduced by increasing access to affordable contraception. Women should be able to choose when and whether to use contraception, choose which method to use, and have ready access to their chosen method. State and national government should support unrestricted access to all contraceptives. As obstetrician-gynecologists, we have a critical mandate, based on...

Published: 09/23/2019

American journal of obstetrics and gynecology pmid:31542250

Age-Associated Risk of 90-Day Postoperative Mortality After Cytoreductive Surgery for Advanced Ovarian Cancer

Alexander Melamed, Alexandra S Bercow, Katherine Bunnell, J Alejandro Rauh-Hain, Jason D Wright, Laurel W Rice, Marcela G Del Carmen

This study explores the association of the risk of 90-day mortality with age for US women with advanced ovarian cancer undergoing cytoreductive surgery.

Published: 05/09/2019

JAMA surgery pmid:31066875

The American Gynecological and Obstetrical Society-reinvigorating for the 21st century

Laurel W Rice, Charles J Lockwood, Maureen Phipps, John O L Delancey, Ronald D Alvarez, Marcelle I Cedars

The American Gynecological and Obstetrical Society (AGOS) has the potential to serve as a unifying organization to advocate for women's reproductive health care, education, and research. This report reviews a strategic plan designed to reinvigorate AGOS to address, together with our partner organizations, the ever more pressing issues and challenges in women's reproductive health.

Published: 01/10/2019

American journal of obstetrics and gynecology pmid:30625296

Variation in resource utilization associated with the surgical management of ovarian cancer

J Alejandro Rauh-Hain, Michael K Hidrue, Peter Gaccione, Alexander Melamed, Larissa A Meyer, Nancy L Keating, Sharon H Giordano, Laurel W Rice, Michael J Birrer, Marcela G Del Carmen

CONCLUSIONS: We identified significant variation in standardized costs among women who underwent surgery for ovarian cancer, operating room and supply costs are the largest drivers of variation.

Published: 12/24/2018

Gynecologic oncology pmid:30579568

Trends and comparative effectiveness of inpatient radical hysterectomy for cervical cancer in the United States (2012-2015)

Shitanshu Uppal, J Rebecca Liu, R Kevin Reynolds, Laurel W Rice, Ryan J Spencer

CONCLUSIONS: Perioperative complications are significantly lower for MIS procedures. These data should be used for contemporary cost-effective analysis and comprehensive counseling regarding risks and benefits of the surgical approach for cervical cancer.

Published: 11/15/2018

Gynecologic oncology pmid:30424895

Disparities in the allocation of research funding to gynecologic cancers by Funding to Lethality scores

Ryan J Spencer, Laurel W Rice, Clara Ye, Kaitlin Woo, Shitanshu Uppal

CONCLUSION: Funding to Lethality scores for gynecologic cancers are significantly lower than other cancer sites, indicating a disparity in funding allocation that persists over the most recent eight years of available data. Prompt correction is required to ensure critical discoveries for women with gynecologic cancers.

Published: 11/09/2018

Gynecologic oncology pmid:30404721

Survival after Minimally Invasive Radical Hysterectomy for Early-Stage Cervical Cancer

Alexander Melamed, Daniel J Margul, Ling Chen, Nancy L Keating, Marcela G Del Carmen, Junhua Yang, Brandon-Luke L Seagle, Amy Alexander, Emma L Barber, Laurel W Rice, Jason D Wright, Masha Kocherginsky, Shohreh Shahabi, J Alejandro Rauh-Hain

CONCLUSIONS: In an epidemiologic study, minimally invasive radical hysterectomy was associated with shorter overall survival than open surgery among women with stage IA2 or IB1 cervical carcinoma. (Funded by the National Cancer Institute and others.).

Published: 11/01/2018

The New England journal of medicine pmid:30379613

Isolated para-aortic lymph node metastasis in FIGO stage IA2-IB2 carcinoma of the cervix: Revisiting the role of surgical assessment

Marcela G Del Carmen, Rene Pareja, Alexander Melamed, Juliana Rodriguez, Anna Greer, Rachel M Clark, Laurel W Rice

CONCLUSIONS: In patients undergoing radical hysterectomy and pelvic lymphadenectomy for stage IA2-IB2 cervical cancer, para-aortic lymph node dissection is not warranted based on the low risk of isolated metastatic disease, and lack of survival benefit associated with the procedure.

Published: 07/19/2018

Gynecologic oncology pmid:30017539

Thirty-day unplanned hospital readmission in ovarian cancer patients undergoing primary or interval cytoreductive surgery: systematic literature review

Rachel M Clark, Laurel W Rice, Marcela G Del Carmen

CONCLUSIONS: Policies and programs should be designed to measure short- and long-term outcomes in this patient population to avoid bias in assigning patients to NACT-ICS to maintain low 30-day readmission rates.

Published: 06/23/2018

Gynecologic oncology pmid:29929923

Hospital Readmission as a Poor Measure of Quality in Ovarian Cancer Surgery

Shitanshu Uppal, Ryan J Spencer, Laurel W Rice, Marcela G Del Carmen, R Kevin Reynolds, Jennifer J Griggs

CONCLUSION: Hospitals with 31 cases per year or more have a lower 30- and 90-day mortality despite performing more complex surgeries, are more likely to be adherent to guideline-based care, and achieved higher overall survival.

Published: 06/12/2018

Obstetrics and gynecology pmid:29889756

Preoperative obstructive sleep apnea screening in gynecologic oncology patients

Ross F Harrison, Erin E Medlin, Chase B Petersen, Stephen L Rose, Ellen M Hartenbach, David M Kushner, Ryan J Spencer, Laurel W Rice, Ahmed N Al-Niaimi

CONCLUSION: The prevalence of obstructive sleep apnea or screening at risk for the condition is high among women presenting for surgery with a gynecologic oncologist. Providers should consider evaluating a patient's risk for obstructive sleep apnea in the preoperative setting, especially when risk factors for the condition are present.

Published: 05/25/2018

American journal of obstetrics and gynecology pmid:29792853

Factors associated with outcomes and inpatient 90-day cost of care in endometrial cancer patients undergoing hysterectomy - implications for bundled care payments

Aimee Rolston, Ryan J Spencer, R Kevin Reynolds, Laurel W Rice, Shitanshu Uppal

CONCLUSIONS: Class III obesity was associated with higher medical (but not surgical) complication rates as well as increased overall inpatient care cost when compared to the non-obese population. Number of comorbidities significantly impacted the cost and outcomes after hysterectomy. As more healthcare initiatives focus on bundled payments, our results suggest that payment packages should adjust for obesity rates and medical comorbidities stratified by region and hospital type in order to fairly...

Published: 05/21/2018

Gynecologic oncology pmid:29778507

Expanding the pipeline. The 2018 Society of Gynecologic Oncology presidential address

Laurel W Rice

No abstract

Published: 05/07/2018

Gynecologic oncology pmid:29729931

Obstructive Sleep Apnea and the Impact on Surgical Outcomes in Gynecology

Erin E Medlin, Laurel W Rice, Ahmed Al-Niaimi

CONCLUSIONS AND RELEVANCE: Increased diagnosis and treatment for OSAS in the perioperative period can improve perioperative outcomes, surgical outcomes, and long-term patient outcomes. Strategies to increase effective management in patients presenting for gynecologic surgery are needed.

Published: 04/28/2018

Obstetrical & gynecological survey pmid:29701869

Racial and ethnic disparities over time in the treatment and mortality of women with gynecological malignancies

J Alejandro Rauh-Hain, Alexander Melamed, Diego Schaps, Amy J Bregar, Ryan Spencer, John O Schorge, Laurel W Rice, Marcela G Del Carmen

CONCLUSION: Significant racial disparities persist in the delivery of evidence-based care. Black women with ovarian, endometrial, and cervical cancer continue to experience higher cancer-specific mortality than other groups.

Published: 04/02/2018

Gynecologic oncology pmid:29605048

Towards the elimination of health care disparities in gynecologic oncology: Call to action

Marcela G Del Carmen, Laurel W Rice

No abstract

Published: 04/02/2018

Gynecologic oncology pmid:29605042

Estimating potential for savings for low risk endometrial cancer using the Endometrial Cancer Alternative Payment Model (ECAP): A companion paper to the Society of Gynecologic Oncology Report on the Endometrial Cancer Alternative Payment Model

Jason D Wright, Laura J Havrilesky, David E Cohn, Yongmei Huang, Jill Rathbun, Laurel W Rice, Carol L Brown, Ronald D Alvarez, Emily M Ko

CONCLUSION: An ECAP model demonstrates that reimbursements vary by public versus commercial payers in the U.S. for the surgical management of endometrial cancer patients, and that opportunities for cost savings exist. Nominal increases in the rate of minimally invasive surgery and reduction in the rate of ED visits/readmissions and length of stay can result in substantial savings for endometrial cancer care.

Published: 03/03/2018

Gynecologic oncology pmid:29496293

Ninety-Day Mortality as a Reporting Parameter for High-Grade Serous Ovarian Cancer Cytoreduction Surgery

Ryan J Spencer, Kari E Hacker, Jennifer J Griggs, Laurel W Rice, R Kevin Reynolds, Shitanshu Uppal

CONCLUSION: Compared with low-volume centers, ultra-high-volume centers are associated with significantly lower 30- and 90-day risk-adjusted mortality. The 90-day mortality rate is double that of the 30-day rate and may be a better metric for assessing the initial quality of care for patients with ovarian cancer.

Published: 07/12/2017

Obstetrics and gynecology pmid:28697111

The impact of physician burnout on clinical and academic productivity of gynecologic oncologists: A decision analysis

Taylor B Turner, Sarah E Dilley, Haller J Smith, Warner K Huh, Susan C Modesitt, Stephen L Rose, Laurel W Rice, Jeffrey M Fowler, J Michael Straughn

CONCLUSIONS: The impact of burnout on clinical and academic productivity is substantial across all specialties. As health care systems struggle with human resource shortages, this study highlights the need for effective burnout prevention and wellness programs for gynecologic oncologists. Unless significant resources are designated to wellness programs, burnout will increasingly affect the care of our patients and the advancement of our field.

Published: 06/29/2017

Gynecologic oncology pmid:28655413

Management of menopausal symptoms in women with gynecologic cancers

Marcela G Del Carmen, Laurel W Rice

CONCLUSIONS: Candidates for hormone therapy in gynecologic oncology include women with menopausal symptoms diagnosed with low-grade, early-stage endometrial cancer, cervical, vulvar and vaginal cancer, and ovarian cancer.

Published: 06/20/2017

Gynecologic oncology pmid:28625396

The clinical trials crisis in gynecologic oncology

Marcela G Del Carmen, Christina M Annunziata, Laurel W Rice

No abstract

Published: 04/16/2017

Gynecologic oncology pmid:28410755

Hysterectomy: More Harm Than Good or Innocent Bystander?

Laurel W Rice, Heidi W Brown

No abstract

Published: 02/09/2017

Diseases of the colon and rectum pmid:28177986

Disparities in receipt of care for high-grade endometrial cancer: A National Cancer Data Base analysis

Amy J Bregar, J Alejandro Rauh-Hain, Ryan Spencer, Joel T Clemmer, John O Schorge, Laurel W Rice, Marcela G Del Carmen

CONCLUSIONS: Among women with high-grade endometrial cancer, African American women have lower all-cause survival while Hispanic women have higher all-cause survival compared to white women after controlling for treatment, sociodemographic, comorbidity and histopathologic variables.

Published: 02/05/2017

Gynecologic oncology pmid:28159409

Association of Hospital Volume With Racial and Ethnic Disparities in Locally Advanced Cervical Cancer Treatment

Shitanshu Uppal, Christina Chapman, Ryan J Spencer, Shruti Jolly, Kate Maturen, J Alejandro Rauh-Hain, Marcela G delCarmen, Laurel W Rice

CONCLUSION: Racial and ethnic disparities in the delivery of guideline-based care are the highest in high-volume hospitals. Guideline-based care in locally advanced cervical cancer is associated with improved survival.

Published: 01/13/2017

Obstetrics and gynecology pmid:28079775

Minimally Invasive Staging Surgery in Women with Early-Stage Endometrial Cancer: Analysis of the National Cancer Data Base

Amy J Bregar, Alexander Melamed, Elisabeth Diver, Joel T Clemmer, Shitanshu Uppal, John O Schorge, Laurel W Rice, Marcela G Del Carmen, J Alejandro Rauh-Hain

CONCLUSION: There are notable racial, ethnic, socioeconomic, and geographic variations in the utilization of MIS for endometrial cancer staging in the US. After controlling for the aforementioned factors, MIS had a similar 3-year survival compared with laparotomy in women undergoing staging surgery for endometrial cancer.

Published: 01/12/2017

Annals of surgical oncology pmid:28074326

International Gynecologic Cancer Society (IGCS) 2016: Meeting report

Marcela G Del Carmen, Laurel W Rice

No abstract

Published: 11/17/2016

Gynecologic oncology pmid:27847107

Timing of and Reasons for Unplanned 30-Day Readmission After Hysterectomy for Benign Disease

Courtney A Penn, Daniel M Morgan, Laurel W Rice, John A Harris, J Alejandro Rauh-Hain, Shitanshu Uppal

CONCLUSION: Readmissions after hysterectomy tend to occur shortly after discharge. Most readmissions are related to surgical issues, most commonly surgical site infection. Medical complications, including venous thromboembolism, account for less than 10% of readmissions. Readmission reduction efforts should focus on early postdischarge follow-up, preventing infectious complications, and determining preventability of surgical-related reasons for readmission.

Published: 09/09/2016

Obstetrics and gynecology pmid:27607868

Trends in hospice discharge, documented inpatient palliative care services and inpatient mortality in ovarian carcinoma

Shitanshu Uppal, Laurel W Rice, Anurag Beniwal, Ryan J Spencer

CONCLUSIONS: The use of hospice as a discharge destination and documented palliative care services is relatively low but appears to be increasing over time for mOvCa patients. Monitoring this data is vital to plan educational programs regarding palliative care approaches in this at-risk population.

Published: 08/21/2016

Gynecologic oncology pmid:27542965

Variation in care in concurrent chemotherapy administration during radiation for locally advanced cervical cancer

Shitanshu Uppal, Marcela G Del Carmen, Laurel W Rice, R Kevin Reynolds, Shruti Jolly, Amy Bregar, Zaid M Abdelsattar, J Alejandro Rauh-Hain

CONCLUSION: Rates of C-CRT administration varied significantly across hospitals in the United States. Hospitals with a high case volume had higher rates and more consistent patterns of C-CRT administration. Furthermore, we identified independent factors, all of which represent noteworthy health disparities, associated with lower rates of C-CRT administration.

Published: 05/29/2016

Gynecologic oncology pmid:27234144

Safety and tolerability of chlorhexidine gluconate (2%) as a vaginal operative preparation in patients undergoing gynecologic surgery

Ahmed Al-Niaimi, Laurel W Rice, Uppal Shitanshu, Bonnie Garvens, Megan Fitzgerald, Sara Zerbel, Nasia Safdar

CONCLUSIONS: The use of 2% CHG as a vaginal operative preparation is not associated with increased vaginal irritation compared with PI in gynecologic surgery. It can safely be used, taking advantage of its efficacy in reducing vaginal bacterial colony counts.

Published: 05/29/2016

American journal of infection control pmid:27234011

Readmissions after major gynecologic oncology surgery

Shitanshu Uppal, Courtney Penn, Marcela G Del Carmen, J Alejandro Rauh-Hain, R Kevin Reynolds, Laurel W Rice

CONCLUSIONS: Efforts to reduce readmission rates should focus on identifying patients at a high risk of readmission and reducing surgical site infections. Additionally, prospective evaluation of interventions targeted at reducing readmissions should focus on the first two weeks after discharge from the hospital.

Published: 03/02/2016

Gynecologic oncology pmid:26927757

An Open Letter to the Food and Drug Administration Regarding the Use of Morcellation Procedures in Women Having Surgery for Presumed Uterine Myomas

William Parker, Jonathan S Berek, Elizabeth Pritts, David Olive, Andrew M Kaunitz, Eva Chalas, Daniel Clarke-Pearson, Barbara Goff, Robert Bristow, Hugh S Taylor, Robin Farias-Eisner, Amanda Nickles Fader, G Larry Maxwell, Scott C Goodwin, Susan Love, William E Gibbons, Leland J Foshag, Phyllis C Leppert, Judy Norsigian, Charles W Nager, Timothy Johnson, David S Guzick, Sawsan As-Sanie, Richard J Paulson, Cindy Farquhar, Linda Bradley, Stacey A Scheib, Anton J Bilchik, Laurel W Rice, Carla Dionne, Alison Jacoby, Charles Ascher-Walsh, Sarah J Kilpatrick, G David Adamson, Matthew Siedhoff, Robert Israel, Marie Fidela Paraiso, Michael M Frumovitz, John R Lurain, Ayman Al-Hendy, Guy I Benrubi, Steven S Raman, Rosanne M Kho, Ted L Anderson, R Kevin Reynolds, John DeLancey

No abstract

Published: 01/17/2016

Journal of minimally invasive gynecology pmid:26773577

Management for Elderly Women With Advanced-Stage, High-Grade Endometrial Cancer

J Alejandro Rauh-Hain, Kristen J Pepin, Larissa A Meyer, Joel T Clemmer, Karen H Lu, Laurel W Rice, Shitanshu Uppal, John O Schorge, Marcela G Del Carmen

CONCLUSION: Elderly women with high-grade endometrial cancer are less likely to be treated with surgery, chemotherapy, or radiation.

Published: 11/10/2015

Obstetrics and gynecology pmid:26551187

Predictors of 30-day readmission and impact of same-day discharge in laparoscopic hysterectomy

Ashley J Jennings, Ryan J Spencer, Erin Medlin, Laurel W Rice, Shitanshu Uppal

CONCLUSION: The overall readmission rate after laparoscopic hysterectomy is low. Patients discharged the same day have similar rates of readmission. Higher LHRS is indicative of higher rates of readmission and may identify a population not suitable for same-day discharge and in need of higher vigilance to prevent readmissions.

Published: 05/19/2015

American journal of obstetrics and gynecology pmid:25981843

Global health perspective on gynecologic oncology

Marcela G del Carmen, Laurel W Rice, Kathleen M Schmeler

CONCLUSIONS: Prevention is central to global health efforts to close the cancer divide. The gynecologic oncology community is well positioned to lead efforts in global health by partnering with institutions, professional societies and advocacy groups.

Published: 03/19/2015

Gynecologic oncology pmid:25782635

Underrepresentation of women in clinical trials: why gynecologic oncologists are worried

Marcela G Del Carmen, Laurel W Rice

In gynecologic oncology, significant advances with improved patient outcomes have clearly and thankfully resulted from randomized clinical trials. The recent restructuring of cooperative groups and decreased funding for phase III clinical trials have unintentionally resulted in a 90% reduction of available trials and accrual in gynecologic oncology. This Commentary reviews the history of the underrepresentation of women in clinical trials, highlighting the challenges that threaten the viability...

Published: 03/03/2015

Obstetrics and gynecology pmid:25730224

Frailty index predicts severe complications in gynecologic oncology patients

Shitanshu Uppal, Elena Igwe, Laurel W Rice, Ryan J Spencer, Stephen L Rose

CONCLUSIONS: Modified frailty index (mFI) is predictive of the need for critical care support and 30-day mortality after surgery for gynecologic cancer.

Published: 01/21/2015

Gynecologic oncology pmid:25602715

Risk factors for early-occurring and late-occurring incisional hernias after primary laparotomy for ovarian cancer

Ryan J Spencer, Kristin D Hayes, Stephen Rose, Qianqian Zhao, Paul J Rathouz, Laurel W Rice, Ahmed N Al-Niaimi

CONCLUSION: The formation of early incisional hernias after midline incision is associated with poor nutritional status and suboptimal cytoreductive surgery, whereas late hernia formation is associated with advanced age.

Published: 01/09/2015

Obstetrics and gynecology pmid:25568995

Preoperative hypoalbuminemia is an independent predictor of poor perioperative outcomes in women undergoing open surgery for gynecologic malignancies

Shitanshu Uppal, Ahmed Al-Niaimi, Laurel W Rice, Stephen L Rose, David M Kushner, Ryan J Spencer, Ellen Hartenbach

CONCLUSION: Preoperative albumin levels <3g/dL identify a population of patients at a very high-risk of experiencing perioperative morbidity and 30-day mortality after open surgery.

Published: 08/22/2013

Gynecologic oncology pmid:23962700

Current surgical management of endometrial cancer

M Heather Einstein, Laurel W Rice

It is reasonable to perform complete lymphadenectomy in patients at significant risk of lymph node metastases, and use the results to guide adjuvant treatment decisions.(24,25) Criteria for staging based on intraoperative pathology should be determined in consultation with the pathologist, preferably with an institution-specific quality-assurance review.(34) Patients with more aggressive histologies should undergo a staging procedure including an omental biopsy whenever possible, with the...

Published: 01/17/2012

Hematology/oncology clinics of North America pmid:22244663

Human papillomavirus vaccination recommendation may be linked to reimbursement: a survey of Virginia family practitioners and gynecologists

Jennifer L Young, Ruth G Bernheim, Jeffrey E Korte, Mark H Stoler, Thomas M Guterbock, Laurel W Rice

CONCLUSIONS: Gynecologists are providing HPV vaccination at rates similar to family practitioners. Reimbursement concerns may negatively have an impact on doctors' recommendation of the HPV vaccine.

Published: 09/13/2011

Journal of pediatric and adolescent gynecology pmid:21906978

The role of in vitro directed chemotherapy in epithelial ovarian cancer

J Stuart Ferriss, Laurel W Rice

Epithelial ovarian cancer (EOC) continues to be the most lethal gynecologic malignancy. Efforts to personalize chemotherapy treatments by utilizing in vitro tumor assays to predict chemotherapeutic response have been tested in both the primary and recurrent treatment setting. To date, several retrospective studies have suggested improved response rates to predicted chemotherapeutic agents. However, a prospective, controlled trial merely found equivalence between in vitro prediction and empirical...

Published: 09/16/2010

Reviews in obstetrics & gynecology pmid:20842282

Hormone prevention strategies for breast, endometrial and ovarian cancers

Laurel W Rice

The development of effective prevention strategies for breast, endometrial and ovarian cancers (CA), based on hormonal responsiveness, is a paramount opportunity in the care of women at risk for these malignancies. Breast CA prevention, utilizing Selective Estrogen Receptor Modulators (SERMs) is a well-established paradigm in the management of high risk women. Aromatase inhibitors (AI) and prophylactic bilateral salpingo-oophorectomy are presently under investigation for that same purpose....

Published: 05/18/2010

Gynecologic oncology pmid:20471672

Surgical management and postoperative treatment of endometrial carcinoma

Jason A Lachance, Christopher J Darus, Laurel W Rice

Endometrial carcinoma affects over 40,000 American women annually, making it the most common gynecologic malignancy. Over 80% of disease is diagnosed in the early stages, resulting in a generally favorable prognosis for most patients. However, discrepancies still exist with regard to primary surgical management and postoperative adjuvant therapies directed at reducing recurrence rates and improving survival. In this review, we outline the surgical management of newly diagnosed disease and review...

Published: 11/19/2008

Reviews in obstetrics & gynecology pmid:19015760

Utilization of a uniform grading system for interpreting serous ovarian cancer

Jason A Lachance, Jamie Shutter, Kristen A Atkins, Mark H Stoler, Laurel W Rice, Amir A Jazaeri

CONCLUSION: Utilization of a uniform grading system retrospectively correlates with platinum sensitivity.

Published: 05/27/2008

American journal of obstetrics and gynecology pmid:18501326

The Use of p16 in enhancing the histologic classification of uterine smooth muscle tumors

Kristen A Atkins, Nora Arronte, Christopher J Darus, Laurel W Rice

CONCLUSIONS: p16 is preferentially expressed in LMS with only rare L showing positivity. Histologically, tumors with coagulative tumor cell necrosis alone were clinically LMS. In those cases in which the type of necrosis is uncertain (coagulative tumor cell vs. hyalinized), the addition of p16 may aid in discerning a subset of STUMP that should be classified as LMS.

Published: 12/29/2007

The American journal of surgical pathology pmid:18162776

A cost-effective analysis of adjuvant therapies for the treatment of stage I endometrial adenocarcinoma

Jason A Lachance, George J Stukenborg, Bernard F Schneider, Laurel W Rice, Amir A Jazaeri

CONCLUSION: Routine use of adjuvant EBRT or COMB in the management of surgical stage I endometrial adenocarcinoma is not cost-effective. Compared to OBS, post-operative VB improves survival at a cost of $65,900 per survivor, supporting further investigation of this adjuvant therapy.

Published: 10/16/2007

Gynecologic oncology pmid:17936341

Use of cisplatin without desensitization after carboplatin hypersensitivity reaction in epithelial ovarian and primary peritoneal cancer

Megan B Callahan, Jason A Lachance, Rebecca L Stone, Julie Kelsey, Laurel W Rice, Amir A Jazaeri

CONCLUSION: The use of cisplatin without desensitization is a reasonable approach for continuing platinum-based chemotherapy in patients with a significant carboplatin hypersensitivity reaction. Patients should be advised of risks and closely monitored, given published case reports of anaphylaxis.

Published: 08/11/2007

American journal of obstetrics and gynecology pmid:17689649

Cervical adenocarcinoma in situ: the predictive value of conization margin status

Jennifer L Young, Amir A Jazaeri, Jason A Lachance, Mark H Stoler, William P Irvin, Laurel W Rice, Willie A Andersen, Susan C Modesitt

CONCLUSIONS: Even with negative conization margins, women still face a risk of residual, recurrent, or invasive disease.

Published: 08/11/2007

American journal of obstetrics and gynecology pmid:17689647

Biologic targets for therapeutic intervention in endometrioid endometrial adenocarcinoma and malignant mixed müllerian tumors

Laurel W Rice, Rebecca L Stone, Miaohou Xu, Mary Galgano, Mark H Stoler, Elise N Everett, Amir A Jazaeri

CONCLUSION: AKT cascade activation in grade 3 endometrioid endometrial cancers and malignant mixed müllerian tumors is a novel finding. Apoptosis and growth arrest that results from AKT inhibition expose opportunities for therapeutic intervention.

Published: 04/04/2006

American journal of obstetrics and gynecology pmid:16580307

Predictors of suboptimal surgical cytoreduction in women treated with initial cytoreductive surgery for advanced stage epithelial ovarian cancer

Elise N Everett, Cara C Heuser, Lisa M Pastore, Willie A Anderson, Laurel W Rice, William P Irvin, Peyton T Taylor

CONCLUSION: A suboptimal cytoreduction confers no survival advantage to women with advanced ovarian cancer. Thus, these patients may be the best candidates for initial chemotherapy, and identifying them preoperatively becomes important.

Published: 08/16/2005

American journal of obstetrics and gynecology pmid:16098898

The estrogen receptor (ER)alpha variant Delta5 exhibits dominant positive activity on ER-regulated promoters in endometrial carcinoma cells

Winnifred Bryant, Allison E Snowhite, Laurel W Rice, Margaret A Shupnik

Estrogen receptor (ER)alpha is a ligand-inducible transcription factor that mediates the physiological effects of 17beta-estradiol (E2). In the uterus, E2 is involved in tissue growth, maintenance, and differentiation. Delta5ERalpha (Delta5) is an ERalpha variant protein expressed in uterine tumors but not in normal tissue. We examined the transcriptional activity of Delta5 and its modulation of human ERalpha basal and E2-stimulated activity in Ishikawa cells, an endometrial cancer cell line. In...

Published: 11/06/2004

Endocrinology pmid:15528307

Effects of adjunctive Swedish massage and vibration therapy on short-term postoperative outcomes: a randomized, controlled trial

Ann Gill Taylor, Daniel I Galper, Peyton Taylor, Laurel W Rice, Willie Andersen, William Irvin, Xin-Qun Wang, Frank E Harrell

CONCLUSIONS: Gentle Swedish massage applied postoperatively may have minor effects on short-term sensory pain, affective pain, and distress among women undergoing an abdominal laparotomy for removal of suspected malignant tissues.

Published: 04/05/2003

Journal of alternative and complementary medicine (New York, N.Y.) pmid:12676037

Sentinel node biopsy in vulvar and vaginal melanoma: presentation of six cases and a literature review

Liana Abramova, Jaysheree Parekh, William P Irvin, Laurel W Rice, Peyton T Taylor, Willie A Anderson, Craig L Slingluff

CONCLUSIONS: This experience, plus reports of a small number of patients from three similar studies, supports the impression that sentinel lymph node biopsy is feasible for vulvar and vaginal melanoma.

Published: 11/06/2002

Annals of surgical oncology pmid:12417504

"See-and-treat" loop electrosurgical excision. Has the time come for a reassessment?

William P Irvin, Willie A Andersen, Peyton T Taylor, Mark H Stoler, Laurel W Rice

CONCLUSION: The selected use of see-and-treat management of cytologic cervical HSIL is feasible, highly predictive and associated with an extremely low incidence of overtreatment. Such management has the potential to increase patient satisfaction and compliance while drastically reducing health care dollars currently directed toward the management of HSIL. Strong consideration should be given to accepting see-and-treat management as a viable alternative in the care of patients with documented...

Published: 08/13/2002

The Journal of reproductive medicine pmid:12170535

Higgins J, Rice L. Access to contraception and abortion is as critical as ever during COVID-19 pandemic. The Capital Times. April 9, 2020. Available at: https://madison.com/ct/opinion/column/jenny-higgins-and-laurel-rice-access-to-contraception-and-abortion-is-as-critical-as-ever/article_4df7b608-ba4a-562a-8b3a-4c5d2a2f9fca.html


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