Abbott published in Fertility and Sterility

David Abbott, PhD, professor in the UW Ob-Gyn Division of Reproductive Sciences, co-authored a new publication in Fertility and Sterility!

“Randomized clinical trial: effect of low-dose flutamide on abdominal adipogenic function in normal-weight women with polycystic ovary syndrome” shares results from a human clinical trial that demonstrates that a low dose of the androgen receptor blocker, flutamide, given for 6 months to normal weight women with PCOS, diminishes their android abdominal fat accumulation and circulating lipid, while also diminishing their insulin resistance and improving their regulation of glucose.

It is the first anti-androgen intervention study involving non-overweight and obese women with PCOS and implicates elevated testosterone as a major causal factor in PCOS metabolic pathophysiology when obesity is absent or before it develops. The study was funded by an NIH P50 Center grant based at OHSU and the Oregon National Primate Research Center.

Read the whole study here!

Fertility and Sterility commissioned a commentary about this article as well. Read the Reflections piece “Polycystic ovarian syndrome: a second-take on flutamide” for more perspective.