Barroilhet to collaborate on WPP new investigator grant

Lisa Barroilhet, MD, MS, associate professor and director of the Division of Gynecologic Oncology, will be collaborating on a New Investigator Grant from the Wisconsin Partnership Program! Barroilhet will work with principal investigator Daniel Matson, MD, PhD, assistant professor in the Department of Pathology and Laboratory Medicine, and fellow collaborator Pam Kreeger, PhD, professor in the Department of Pathology and Laboratory Medicine.

The project, GATA2 Regulated Piezo1 Controls Uterine Serous Carcinoma Invasion, investigates how the interaction between the proteins GATA2 and Piezo1 drives invasion in uterine serous carcinoma, a rare but extremely aggressive form of uterine cancer that contributes to cancer deaths among postmenopausal women. Building on findings that GATA2 may help predict which tumors are likely to recur, the study uses patient-derived cancer cells and mouse models to understand how these factors work together to promote tumor spread. 

By clarifying these mechanisms, the project aims to improve risk stratification, allowing clinicians to spare low-risk patients from unnecessary chemotherapy while directing more intensive treatment to those at highest risk. 

Congratulations to the researchers!

**by Ob-Gyn Communications Intern Melis Baskaya