Kushner and Codispoti co-author a study featured on cover of International Journal of Gynecologic Pathology

David Kushner, MD, professor in the Division of Gynecologic Oncology, and Nicolette Codispoti, MD, MS, MPH, PGY-3 resident, recently co-authored a study featured on the cover of the International Journal of Gynecologic Pathology. Additional authors include Jin Xu, MD, MS; Lauren Montemorano, MD; Elizabeth Sadowski, MD; and Paul Weisman, MD. 

In “A Case of CDKN2C/CIC Null Epithelioid Leiomyosarcoma With a Low-grade Component Indistinguishable From Leiomyoma”, the authors report their experience with a challenging case of the recently described CDKN2C/CIC null subtype of uterine leiomyosarcoma (LMS) – a LMS subtype that is frequently epithelioid in appearance, is wild-type for both TP53 and RB1, and may exhibit low-grade histology that falls short of LMS. The results of this case highlight the striking intratumoral heterogeneity that is possible in CDKN2C/CIC null LMS, including areas morphologically indistinguishable from LM. After performing next-generation molecular analysis on the patient’s tumors, the authors found that:

“Despite having areas indistinguishable from conventional leiomyoma, CDKN2C/CIC null LMS has the potential to recur and metastasize. The correct identification of this tumor type at the time of initial diagnosis can facilitate appropriate adjuvant and/or maintenance therapy that may decrease the morbidity associated with extensive debulking surgery.” 

Read the whole article here. 

**by Ob-Gyn Communications Intern Melis Baskaya