Rengarajan, Virumbrales-Muñoz, Boeldt publish in Lab on a Chip
Aishwarya Rengarajan, PhD, María Virumbrales-Muñoz, PhD, assistant professor in the UW Department of Ob-Gyn Division of Reproductive Sciences, and Derek Boeldt, PhD, assistant professor in the UW Department of Ob-Gyn Division of Reproductive Sciences, co-authored a new article published in the journal Lab on a Chip. Co-authors include Hannah E. Goldblatt, CNA, and David J. Beebe, PhD.
In “Immune cells and inflammatory mediators cause endothelial dysfunction in a vascular microphysiological system,” Rengarajan, Virumbrales-Muñoz, Boeldt, and co-authors evaluated the effect of inflammation and cardiovascular disease on vascular microphysiological systems (MPS). Their research found that inflammation contributes to endothelial dysfunction by disrupting the endothelial barrier.
“An inflammatory mixture (TNFα, IL-6, VEGF-A – 10 ng ml−1 each) induces endothelial dysfunction in vascular MPS via disrupted network level Ca2+ activity with 1 h exposure and via increased permeability with 48 hour exposure.”
Read the whole article here.
**by Ob-Gyn Communications Intern Paige Stevenson