Clinical Research

Clinical Research

Current Studies by Division

Clinical Evaluation of the Xpert Xpress GBS Test (“GBS260C”)

Principal Investigator: Makeba Williams, MD
IRB: Advara
Funding: Cepheid (Industry sponsored)

Purpose: This study will evaluate the performance of the XpertXpress GBS test in a method comparison study where the XpertXpress GBS test results are compared to enriched bacterial culture. This study is a multi-site observational study and will include testing vaginal/rectal swab specimens collected at antepartum from pregnant female study participants.

The goal of the Gynecologic Oncology Clinical Research Program is to advance treatment through research. To accomplish this, our dedicated team of professionals works to offer the latest cancer clinical trials, where patients volunteer to participate in clinical research and receive novel cancer treatments. The clinical trials program is robust, with dozens of cancer research trials currently open. In addition, at the UW Carbone Cancer Center, women with metastatic disease can get a no-cost genetic analysis of their cancer that may reveal mutations that can be targeted with new drugs. Other ongoing research is as simple as donating extra tissue from surgery, or participating in a research database to track treatment response.

Chronic Hypertension and Pregnancy (“CHAP”) 

Principal Investigator: Kara Hoppe, DO
IRB #2016-1184
Funding: NIH

Purpose: This is a prospective randomized trial investigating the use of antihypertensive medication to manage mild chronic hypertension in pregnant women. Women with chronic mild hypertension are randomized to receive medication or no medication. Two study visits occur during: the first is during the consenting visit, and the second during the mid-trimester. Women can elect to have a blood draw taken for the study. These blood draws normally occur at each of the study visits and at the time of delivery.


Preeclampsia: inflammatory cytokine profile changes with in vitro exposure to vitamin C and brachial artery fluid dynamics (PRE-E-C1 Trial): “Vitamin C” 

Principal Investigator: Jenna Racine, MD
UPH IRB #2019-017
Funding: Meriter Foundation

Purpose: Study brachial artery reactivity and inflammatory cytokine profiles changes after vitamin C in patients with preeclampsia with severe features. Studying two groups of people: patients with preterm preeclampsia with severe features and pregnant controls. Patients receive a blood draw and an ultrasound of their arm. The blood is used for immune cell and inflammatory cytokine profile tests within the UW Perinatal Labs.


Pre-labor rupture of membranes managed with oral misoprostol versus intravenous oxytocin ("The PROMMO Trial") 

Principal Investigator: Jacquelyn Adams, MD
UPH IRB #2020-003
Funding: Meriter Foundation

Purpose: To compare two medications, Misoprostol and Pitocin, used for inducing labor when a woman has broken her water but is not yet in labor, to see which medication will make labor go faster and determine if there are any additional benefits to the mother. Both medications are used regularly in the hospital and are considered standard of care.


Postpartum Ultrasound Evaluation of the Inferior Vena Cava, Aorta, and Brachial Artery as Predictors for Persistent Postpartum Hypertension (“IVC-Ao”) 

Principal Investigator: Igor Iruretagoyena, MD; Jenna Racine, MD
UPH IRB #2020-005
Funding: Meriter Foundation

Purpose: to study IVC collapsibility, IVC-aortic index, and brachial artery reactivity in postpartum women with and without hypertension. We will study these ultrasound parameters as markers for persistent postpartum hypertension. We will be performing the ultrasounds every day the patient remains in the hospital postpartum, starting on PPD1 up until PPD3. There will be 62 patients in each group for a total of 124 patients.


Advancing postpartum care for Black women in Wisconsin by engaging community partners with a home telehealth service for hypertension– a feasibility project (“Telehealth for Black Women”) 

Principal Investigator: Kara Hoppe, DO
UPH IRB #2020-017
Funding: Wisconsin Partnership Program

Purpose: The immediate primary goal of this proposal is to align efforts of healthcare and community providers throughout the postpartum period to address current gaps in postpartum care for Black women in Dane County. This program will incorporate new elements to specifically address social, mental health and lactation needs to the current postpartum telehealth program. This effort will be a collaboration between the UW Department of Obstetrics & Gynecology, UnityPoint-Meriter Hospital, Harambee Village Doulas, and Anesis Therapy Center. Our long-term goal is to promote telehealth services (beyond hypertension) as a novel way to increase access to a wider breadth of services for all postpartum women.

Personalized Reproductive Medicine in PCOS (“PCOS-IVF”)

Principal Investigators: Laura Cooney, MD; Aleks Stanic-Kostic, MD, PhD
IRB # 2018-1247
Funding: American Society for Reproductive Medicine and start-up funds

Purpose: to analyze the immune profile of women with and without PCOS undergoing in vitro fertilization treatment. The study aim to identify key profiles in women with PCOS can help determine a course of treatment that can improve the chances of conceiving in women with PCOS.

Angiotensin 2 receptor expression/activation in endothelial cells in preeclampsia (“AT2R”)

Principal Investigators: Dinesh Shah, MD; Sathish Kumar, DVM, PhD
UPH IRB #2018-008
Funding: NIH

Purpose: To determine if the expression and activation of the Angiotensin 2 receptors is different in the blood vessels of women with preeclampsia compared to women with an uncomplicated pregnancy. Study includes placenta donation and/or an omental biopsy during caesarean section.


Systems Biology of Immunity in Pregnancy Complications (“Preterm Birth Study”)

Principal Investigator: Aleks Stanic-Kostic, MD, PhD
UPH IRB # 2018-010
Funding: Burroughs Wellcome Fund

Purpose: To analyze the immune profile of women with preterm delivery and term delivery. The goal is to identify key differences in the immune profile (if any) than can later be used to predict the risk of preterm delivery or develop a treatment.

To learn more about ongoing clinical research in the UW Department of Ob-Gyn, contact:

Jennifer Poetter
Clinical Research Administrator

Phone: (608) 417-6941
jennifer.poetter@wisc.edu

McConnell Hall
1010 Mound Street
Madison, WI 53715

To learn more about gynecologic cancer clinical trials at the UW Carbone Cancer Center, contact:

Claire Kostechka, ACRP-CP
Gyn Onc Clinical Research Program Manager
UW Carbone Cancer Center

Phone: (608) 263-7282
kostechka@wisc.edu