The Department of Obstetrics and Gynecology has a strong commitment to basic, translational, and clinical research.
Clinical Research - Current Studies
PI: Dinesh Shah, MD
The purpose of the study is to increase understanding of the placenta’s structure, function and development during pregnancy through MRI and Ultrasound. Previous studies have focused on the placenta after delivery, however the U01 study focuses on the placenta while it’s doing its job for the first time in history. Study involves 2 MRIs and 3 ultrasounds throughout pregnancy, urine and blood samples and optional placental donation at delivery.
PI: Kara Hoppe, DO
UW Madison/Meriter Unity Point serves as a site for a Multicenter Project (Primary site is UAB). The purpose of the study is to evaluate whether a blood pressure treatment strategy to achieve targets that are beneficial for non-pregnant adults is safe and effective during pregnancy. Patients with chronic hypertension are randomized to a treatment group (blood pressure medication) or non-treatment group. Participation includes monitoring of blood pressure and collection of blood and urine samples at different time points.
Collection of specimens such as blood from the umbilical cord, cord tissue and/or placenta tissue. These tissues would otherwise be discarded after delivery. Tissue samples will be used in research studies to learn more about conditions that affect women and babies during pregnancy.
The purpose of the study is to determine whether applying a lidocaine patch around the Cesarean delivery incision will decrease the need for opioid medications for pain control. Women who participate in this study will be randomly assigned to receive lidocaine patches or placebo patches around the incision site. No pain medications will be taken away from patients who participate in the study. Participation also involves completing online questionnaires at 2 and 6 weeks after delivery.
PI: Dinesh Shah, MD
The purpose of the study is to investigate whether AT2R expression in endothelial cells plays a role in preeclampsia and if it is activated in preeclamptic vascular dysfunction. Blood vessels may be at the root of preeclampsia and they will be studied to learn more about how they work in a person with preeclampsia, compared to a person without preeclampsia. Participation includes an omental biopsy if having a C-section and placental donation.
The purpose of the study is to learn about the unique immune component of women undergoing IVF and potentially identify proteins in the immune system that may be used to predict the success rate of pregnancy in women with PCOS undergoing IVF. Participation involves 2 blood draws and completing questionnaires.