Matthew K Wagar, Aaditi Naik, Ran Catherine Zhang, Amy Godecker, Ellen M Hartenbach, Janelle N Sobecki, Sumer K Wallace
CONCLUSIONS: The incidence of postoperative VTE is low in patients undergoing radical vulvar surgery in this national cohort. Inguinofemoral lymph node dissection by any method does not appear to be a risk factor for VTE when compared to radical vulvectomy alone. Further research is needed to determine if extended VTE prophylaxis is beneficial in this population.
Published: 05/25/2024
Gynecologic oncology pmid:38795507
Lauren Montemorano, Zoey B Shultz, Alma Farooque, Meredith Hyun, Richard J Chappell, Ellen M Hartenbach, Jessica D Lang
CONCLUSIONS: TP53 hotspot mutations or high pathogenicity scores were not associated with platinum resistance or refractory disease. Contrary to prior studies, TP53 gain-of-function mutations were not associated with platinum resistance. Estimation of TP53 gain-of-function effect using missense mutation phenotype scores was not associated with platinum resistance. The polymorphic nature of TP53 mutations may be too complex to demonstrate effect using simple models, or response to platinum...
Published: 03/31/2024
Gynecologic oncology pmid:38555766
Grace C Blitzer, Shuang G Zhao, Kristin A Bradley, Ellen M Hartenbach
No abstract
Published: 08/30/2023
Gynecologic oncology pmid:37648640
Robert F Ozols, Brian N Bundy, Benjamin E Greer, Jeffrey M Fowler, Daniel Clarke-Pearson, Robert A Burger, Robert S Mannel, Koen DeGeest, Ellen M Hartenbach, Rebecca Baergen
Purpose: In randomized trials the combination of cisplatin and paclitaxel was superior to cisplatin and cyclophosphamide in advanced-stage epithelial ovarian cancer. Although in nonrandomized trials, carboplatin and paclitaxel was a less toxic and highly active combination regimen, there remained concern regarding its efficacy in patients with small-volume, resected, stage III disease. Thus, we conducted a noninferiority trial of cisplatin and paclitaxel versus carboplatin and paclitaxel in this...
Published: 08/29/2023
Journal of clinical oncology : official journal of the American Society of Clinical Oncology pmid:37643542
Dandi Huang, Ross Harrison, Erin Curtis, Nina Mirabadi, Grace Yi Chen, Roxana Alexandridis, Lisa Barroilhet, Stephen Rose, Ellen Hartenbach, Ahmed Al-Niami
CONCLUSIONS: In this study, 35% of the women with advanced ovarian cancer had at least one unplanned readmission during the entire treatment time. Patients treated by primary cytoreductive surgery spent more days during readmission than those with neoadjuvant chemotherapy. Readmissions did not affect progression-free survival and may not be valuable as a quality metric.
Published: 02/22/2023
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:36808044
Janelle Sobecki, Benjamin Weigman, India Anderson-Carter, Lisa Barroilhet, Thevaa Chandereng, Mark Kliewer, Ellen Hartenbach
CONCLUSIONS: Women with gynecologic cancers may experience accelerated cancer treatment-induced bone loss. Routine CT imaging is a convenient screening modality to identify those at highest risk for osteoporosis who warrant further evaluation with dual-energy X-ray absorptiometry. Routine bone mineral density assessments 1 year following oophorectomy for cancer treatment may be warranted in this population.
Published: 02/01/2022
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:35101963
Matthew K Wagar, Janelle N Sobecki, Thevaa Chandereng, Ellen M Hartenbach, Sumer K Wallace
CONCLUSIONS: The incidence of postoperative VTE in patients with gynecologic cancers undergoing MIS is low and does not appear to differ by MIS modality. Given the very low incidence of postoperative VTE, extended chemoprophylaxis is unlikely to benefit patients with gynecologic malignancies undergoing MIS procedures.
Published: 06/21/2021
Gynecologic oncology pmid:34148718
Claire Hoppenot, Ramey D Littell, Timothy DeEulis, Ellen M Hartenbach
Cervical cancer is the most common gynecologic cancer worldwide. Almost all are related to human papillomavirus exposure. Cervical cancer treatment is associated with significant morbidity that is likely to require support from palliative care teams. In these pearls on cervical cancer, we hope to inform providers about the common treatments and issues for cervical cancer patients. Treatment modalities include surgery for early-stage disease, radiation therapy for locally advanced disease, and...
Published: 01/29/2021
Journal of palliative medicine pmid:33513069
Janelle N Sobecki, Laurel W Rice, Ellen M Hartenbach
Cancer treatment-induced bone loss is a known side effect of cancer therapy that increases the risk of osteoporosis and bone fracture. Women with gynecologic cancer are at increased risk of bone loss secondary to the combined effect of oophorectomy and adjuvant therapies. Data regarding bone loss in women with gynecologic cancers are overall lacking compared to other cancer populations. Consequently, guidelines for osteoporosis screening in women with cancer are largely based on data generated...
Published: 12/14/2020
Gynecologic oncology pmid:33309416
Ellen M Hartenbach, Hsiang-Hui Daphne Kuo, Madelyne Z Greene, Emily A Shrider, Kathleen M Antony, Deborah B Ehrenthal
CONCLUSION: The odds of blood transfusion were higher for women in rural areas. The results indicate that the rurality of the county where the birth occurred was associated with more transfusion. This may reflect differences in maternity and blood banking services in rural hospitals and warrants further study to identify opportunities for intervention.
Published: 02/07/2020
Obstetrics and gynecology pmid:32028506
Ross F Harrison, Erin E Medlin, Chase B Petersen, Stephen L Rose, Ellen M Hartenbach, David M Kushner, Ryan J Spencer, Laurel W Rice, Ahmed N Al-Niaimi
CONCLUSION: The prevalence of obstructive sleep apnea or screening at risk for the condition is high among women presenting for surgery with a gynecologic oncologist. Providers should consider evaluating a patient's risk for obstructive sleep apnea in the preoperative setting, especially when risk factors for the condition are present.
Published: 05/25/2018
American journal of obstetrics and gynecology pmid:29792853
Jody Silva, Ellen Hartenbach, Robert N Golden
No abstract
Published: 01/23/2018
WMJ : official publication of the State Medical Society of Wisconsin pmid:29357213
Amanda N Fader, James Java, Meaghan Tenney, Stephanie Ricci, Camille C Gunderson, Sarah M Temkin, Nick Spirtos, Christina L Kushnir, Michael L Pearl, Oliver Zivanovic, Krishnansu S Tewari, David O'Malley, Ellen M Hartenbach, Chad A Hamilton, Natalie S Gould, Robert S Mannel, William Rodgers, Joan L Walker
CONCLUSIONS: Women with apparent early-stage, USC and CS histologies have poorer outcomes than women with grade 3 endometrioid adenocarcinoma. Patterns of recurrence and survival were not impacted by surgical approach.
Published: 10/17/2016
Gynecologic oncology pmid:27743738
Laura B Huffman, Ellen M Hartenbach, Jeanne Carter, Joanne K Rash, David M Kushner
CONCLUSION: Oncology providers can make a significant impact on the QoL of gynecologic cancer survivors by addressing sexual health concerns. Simple strategies can be implemented into clinical practice to discuss and treat many sexual issues. Referral to specialized sexual health providers may be needed to address more complex problems.
Published: 11/12/2015
Gynecologic oncology pmid:26556768
Cassandra L Albertin, Shitanshu Uppal, Ahmed N Al-Niaimi, Songwon Seo, James Louis Hinshaw, Ellen M Hartenbach
CONCLUSIONS: Although clinicians often use tachycardia and low oxygen saturation as triggers to order PE imaging studies, these signs have a very low specificity. Given the findings of our study, accounting for high platelet count and history of VTE increases the pretest probability of CT-PA study.
Published: 06/23/2015
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:26098091
Eenas A Omari, Tomy Varghese, Mark A Kliewer, Josephine Harter, Ellen M Hartenbach
Ultrasound elastography is envisioned as an optional modality to augment standard ultrasound B-mode imaging and is a promising technique to aid in detecting uterine masses which cause abnormal uterine bleeding in both pre- and post-menopausal women. In order to determine the effectiveness of strain imaging, mechanical testing to establish the elastic contrast between normal uterine tissue and stiffer masses such as leiomyomas (fibroids) and between softer pathologies such as uterine cancer and...
Published: 06/15/2015
Journal of biomechanics pmid:26072212
Ahmed N Al-Niaimi, Mostafa Ahmed, Nikki Burish, Saygin A Chackmakchy, Songwon Seo, Stephen Rose, Ellen Hartenbach, David M Kushner, Nasia Safdar, Laurel Rice, Joseph Connor
CONCLUSIONS: Initiating intensive glycemic control for 24h after gynecologic oncology surgery in patients with DM and postoperative hyperglycemia lowers the SSI rate by 35% (OR = 0.5) compared to patients receiving intermittent sliding scale insulin and to a rate equivalent to non-diabetics.
Published: 09/30/2014
Gynecologic oncology pmid:25263249
Shitanshu Uppal, Ahmed Al-Niaimi, Laurel W Rice, Stephen L Rose, David M Kushner, Ryan J Spencer, Ellen Hartenbach
CONCLUSION: Preoperative albumin levels <3g/dL identify a population of patients at a very high-risk of experiencing perioperative morbidity and 30-day mortality after open surgery.
Published: 08/22/2013
Gynecologic oncology pmid:23962700
Onur Guralp, Susan M Sheridan, Josephine Harter, James Louis Hinshaw, Songwon Seo, Ellen M Hartenbach, Steven Lindheim, Sarah Stewart, David M Kushner
CONCLUSIONS: Most patients with early endometrial cancer can undergo SIS procedures with adequate cytology specimens obtained from distention media. However, the sensitivity is low, and refinements are necessary before utilizing as a diagnostic test. In cases with positive results, the patient may be able to avoid other costly and painful procedures.
Published: 07/25/2013
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:23881100
Shitanshu Uppal, Enrique Hernandez, Moushumi Dutta, Vani Dandolu, Stephen Rose, Ellen Hartenbach
CONCLUSIONS: In ovarian cancer patients undergoing open abdominal surgery, prolonged VTE prophylaxis not only improves patient outcomes, but is also a cost saving strategy when modeled over five years. A significant reduction in the episodes of VTE and a higher overall survival warrants consideration for the routine use of PP in this patient population.
Published: 09/04/2012
Gynecologic oncology pmid:22940486
Ryan J DeWall, Tomy Varghese, Mark A Kliewer, Josephine M Harter, Ellen M Hartenbach
We have characterized the viscoelastic properties of human cervical tissue through a range of precompressional loads and testing frequencies. Mechanical testing is necessary to develop robust elasticity-based techniques for the diagnosis of cervical abnormalities. The storage modulus (E') and material damping (tan 6) were measured in 13 patients, 40 to 76 years old. Our results showed that E' increased monotonically from approximately 4.7 to 6.3 kPa over the precompression range (1-6%) for a...
Published: 01/11/2011
Ultrasonic imaging pmid:21213567
Ahmed N Al-Niaimi, Margaret H Einstein, LaToya Perry, Ellen M Hartenbach, David M Kushner
CONCLUSION: Technically, the surgery is feasible and could be performed by any gynecologic oncologist who is skilled in radical pelvic surgery and the robotic system. The long-term obstetric and oncologic outcome of this technique would be expected to match the outcome of the other radical trachelectomy techniques in the published literature, but is yet to be fully elucidated.
Published: 10/16/2010
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics pmid:20947081
Martee L Hensley, Michael W Sill, Dennis R Scribner, Jubilee Brown, Robert L Debernardo, Ellen M Hartenbach, Carolyn K McCourt, James R Bosscher, Paola A Gehrig
CONCLUSION: Sunitinib fails to achieve sufficient objective response or sustained disease stabilization as second- or third-line treatment for uterine leiomyosarcoma.
Published: 10/09/2009
Gynecologic oncology pmid:19811811
Megan E Jensen, Ellen Hartenbach, Jane A McElroy, Adrienne Faerber, Thomas Havighurst, Kyung Mann Kim, Howard H Bailey
CONCLUSION: Health care professionals in family medicine, pediatrics, and gynecology in Dane County, Wis, have positive attitudes regarding HPV vaccine recommendation for their adolescent patients.
Published: 09/17/2009
WMJ : official publication of the State Medical Society of Wisconsin pmid:19753828
G M Cannon, H Geye, B E Terakedis, D M Kushner, J P Connor, E M Hartenbach, K A Bradley
PURPOSE: To evaluate locoregional control, disease free survival, and overall survival in patients treated with surgery and adjuvant radiation for stage II adenocarcinoma of the endometrium. Secondary goals include identification of prognostic factors and the comparison of toxicity profiles after vaginal cuff brachytherapy (VB) alone or combined with pelvic external beam radiation therapy (EXT).
Published: 02/17/2009
Gynecologic oncology pmid:19217147
M Heather Einstein, David M Kushner, Joseph P Connor, Alex A Bohl, Thomas J Best, Michael D Evans, Richard J Chappell, Ellen M Hartenbach
CONCLUSION: A protocol of dual prophylaxis with prolonged prophylaxis in high-risk patients was successfully implemented and was associated with a significant reduction in the rate of venous thromboembolism without increasing bleeding complications.
Published: 11/04/2008
Obstetrics and gynecology pmid:18978110
D Scott McMeekin, Joan L Walker, Ellen M Hartenbach, Michael A Bookman, Wui-Jin Koh, Gynecologic Oncology Group
CONCLUSION: A regimen of cisplatin 25 mg/m(2) and paclitaxel 20 mg/m(2) weekly with WART was determined to be feasible, but is associated with moderate acute and chronic gastrointestinal toxicity.
Published: 10/31/2008
Gynecologic oncology pmid:18962846
David B Engle, Kristin A Bradley, Rick J Chappell, Joseph P Conner, Ellen M Hartenbach, David M Kushner
CONCLUSION: The LAIB procedure appears safe, but substantially increases operating department time. No significant decrease in late high-grade toxicities were detected in comparison with TrIB. The LAIB procedure allows for both lysis of adhesions and identification of unknown carcinomatosis.
Published: 07/29/2008
Journal of minimally invasive gynecology pmid:18657479
Emily Berry, Steven R Lindheim, Joseph P Connor, Ellen M Hartenbach, Julian C Schink, Josephine Harter, Jens C Eickhoff, David M Kushner
CONCLUSION: Transtubal spill occurs during sonohysterography. No critical spill volume was identified. A highly diagnostic tool when abnormal bleeding is evaluated, sonohysterography has a low probability of cancer cell dissemination.
Published: 05/06/2008
American journal of obstetrics and gynecology pmid:18456240
M Heather Einstein, Ellen M Hartenbach
No abstract
Published: 09/01/2007
Gynecologic oncology pmid:17761279
Maritza A Hobson, Miklos Z Kiss, Tomy Varghese, Amy M Sommer, Mark A Kliewer, James A Zagzebski, Timothy J Hall, Josephine Harter, Ellen M Hartenbach, Ernest L Madsen
CONCLUSIONS: Ultrasound strain imaging can differentiate between endometrial polyps and leiomyomas. More data are necessary to validate these results and to ascertain whether other uterine abnormalities can also be differentiated.
Published: 06/27/2007
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine pmid:17592053
David M Kushner, Joseph P Connor, Michael A Wilson, G Reza Hafez, Richard J Chappell, Sarah L Stewart, Ellen M Hartenbach
CONCLUSIONS: Laparoscopic SLN mapping can be newly introduced into gynecologic oncology centers with high detection rates and negative predictive values. The visualization of blue dye in SLNs is transient, and this negative time correlation may explain the previously reported inferior detection rates with this technique. CLINICAL TRIAL REGISTRATION.: ClinicalTrials.gov, http://www.clinicaltrials.gov, NCT 00205010.
Published: 06/15/2007
Gynecologic oncology pmid:17560635
M Heather Einstein, Elizabeth A Pritts, Ellen M Hartenbach
CONCLUSIONS: All gynecologic cancer patients should receive VTE prophylaxis. Although heparin, LMWH, and SCD have been shown to be safe and effective, due to the paucity of data in the gynecologic oncology literature, no one prevention modality can be considered superior at this time. Adequately powered RCTs are urgently needed to determine the optimal regimen in these high-risk patients.
Published: 04/24/2007
Gynecologic oncology pmid:17449089
David M Kushner, Joseph P Connor, Federico Sanchez, Michael Volk, Julian C Schink, Howard H Bailey, Linda S Harris, Sarah L Stewart, Jason Fine, Ellen M Hartenbach, Wisconsin Oncology Network
CONCLUSION: The weekly regimen of carboplatin and docetaxel has a good response rate with an acceptable toxicity profile.
Published: 01/30/2007
Gynecologic oncology pmid:17258800
Miklos Z Kiss, Maritza A Hobson, Tomy Varghese, Josephine Harter, Mark A Kliewer, Ellen M Hartenbach, James A Zagzebski
The frequency-dependent complex moduli of human uterine tissue have been characterized. Quantification of the modulus is required for developing uterine ultrasound elastography as a viable imaging modality for diagnosing and monitoring causes for abnormal uterine bleeding and enlargement, as well assessing the integrity of uterine and cervical tissue. The complex modulus was measured in samples from hysterectomies of 24 patients ranging in age from 31 to 79 years. Measurements were done under...
Published: 07/25/2006
Physics in medicine and biology pmid:16861774
Heidi Scharf Donovan, Ellen M Hartenbach, Michael W Method
CONCLUSIONS: Women with ovarian cancer experience multiple symptoms, but many do not discuss symptoms with their HCPs and fewer report receiving symptom management recommendations. Women would benefit from more active symptom assessment and discussion of management strategies by HCPs.
Published: 08/23/2005
Gynecologic oncology pmid:16112174
David M Kushner, Regina LaGalbo, Joseph P Connor, Rick Chappell, Sarah L Stewart, Ellen M Hartenbach
CONCLUSION: The results suggest that although the continuous infusion system seems safe, it is not efficacious in this patient population.
Published: 08/02/2005
Obstetrics and gynecology pmid:16055569
Benjamin E Greer, Brian N Bundy, Robert F Ozols, Jeffrey M Fowler, Daniel Clarke-Pearson, Robert A Burger, Robert Mannel, Koen DeGeest, Ellen M Hartenbach, Rebecca N Baergen, Larry J Copeland
CONCLUSION: In the context of a non-randomized comparison, the performance of a SLL was not associated with longer survival.
Published: 07/26/2005
Gynecologic oncology pmid:16039699
Michael Wilkin, Greg Horwitz, Anil Seetharam, Ellen Hartenbach, Julian C Schink, Reginald Bruskewitz, David F Jarrard
Few studies have assessed the long-term risks associated with the Indiana pouch continent urinary diversion after high-dose radiation therapy. A retrospective review of consecutive female patients who underwent cystectomy and Indiana pouch urinary diversion identified 12 with a history of high-dose pelvic irradiation (mean total 78.1 Gy). Long-term complications and outcomes in this group were compared to a synchronous group of patients (n = 14) with no history of radiation. Mean follow-up in...
Published: 05/12/2005
Urologic oncology pmid:15885577
Robert F Ozols, Brian N Bundy, Benjamin E Greer, Jeffrey M Fowler, Daniel Clarke-Pearson, Robert A Burger, Robert S Mannel, Koen DeGeest, Ellen M Hartenbach, Rebecca Baergen, Gynecologic Oncology Group
CONCLUSION: In patients with advanced ovarian cancer, a chemotherapy regimen consisting of carboplatin plus paclitaxel results in less toxicity, is easier to administer, and is not inferior, when compared with cisplatin plus paclitaxel.
Published: 07/16/2003
Journal of clinical oncology : official journal of the American Society of Clinical Oncology pmid:12860964
Ellen M Hartenbach, Joanne M Becker, Elizabeth A Grosen, Howard H Bailey, Daniel G Petereit, Renata Laxova, Julian C Schink
BRCA1 and BRCA2 mutation carriers have an increased risk of developing breast and/or ovarian cancer. Technical advances in genetic testing have increased the need for genetic counseling services; therefore, we have developed a counseling program for these individuals. The purpose of this study is to characterize this population, assess level of interest in genetic testing, and evaluate our program over a 5-year period. Our Familial Cancer Genetic Counseling Program was established in November,...
Published: 09/17/2002
Genetic testing pmid:12229876
D. G. Petereit, S. P. Tannehill, E. A. Grosen, E. M. Hartenbach, J. C. Schink
Petereit DG, Tannehill SP, Grosen EA, Hartenbach EM, Schink JC. Outpatient vaginal cuff brachytherapy for endometrial cancer. The objective of this study was to determine the efficacy and complications of postoperative high-dose-rate (HDR) vaginal-cuff brachytherapy (VCB) in patients with endometrial carcinoma. Between August 1989 to September 1997, 191 patients were treated postoperatively after a total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH/BSO) with outpatient...
Published: 03/10/2001
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:11240811
C M Leys, E M Hartenbach, G R Hafez, D M Mahvi
Metastases to inguinofemoral lymph nodes in patients with carcinoma of the vulva alter the prognosis and treatment of this disease. Our goal was to determine if immunohistochemical staining could reveal occult metastatic nodal disease not detected with routine hematoxylin and eosin staining. We retrospectively examined a total of 110 lymph nodes from 10 patients who had undergone lymph node dissection and found to have all negative nodes. Paraffin embedded lymph nodes were immunostained with a...
Published: 07/25/2000
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists pmid:10907173
E M Hartenbach, L S Harris, H H Bailey, E A Grosen, E Larrison, D Chen, L B Twiggs, J C Schink
CONCLUSION: The addition of hexamethylmelamine to paclitaxel and carboplatin is a well-tolerated multidrug combination for women with advanced ovarian cancer that deserves further testing in a phase III study.
Published: 12/22/1999
The cancer journal from Scientific American pmid:10606476
A R Stettner, E M Hartenbach, J C Schink, R Huddart, J Becker, R Pauli, R Long, R Laxova
Ovarian germ cell cancers are rare malignancies accounting for less than 5% of all ovarian cancers. We present a family in which three closely related women were diagnosed with ovarian germ cell malignancies. This family's cancer history prompted a family history investigation of women treated for ovarian germ cell malignancies in the Gynecologic-Oncology Clinic at the University of Wisconsin. One of the eight patients whose family histories were reviewed had an uncle who had been diagnosed with...
Published: 04/23/1999
American journal of medical genetics pmid:10213045
A K Saltzman, E M Hartenbach, J R Carter, D N Contreras, L B Twiggs, L F Carson, S Ramakrishnan
A variety of cytokines have been identified to play a role in ovarian cancer. In this pilot study, we sought to determine whether transforming growth factor-alpha (TGF-alpha) was detectable in the serum and ascites of women with advanced stage epithelial ovarian cancer. TGF-alpha was measured using an enzyme-linked immunosorbent assay and was present in 18 of 25 control sera. Prior to treatment for stage III or IV epithelial ovarian cancer, 18 patients had undetectable serum levels of TGF-alpha,...
Published: 03/24/1999
Gynecologic and obstetric investigation pmid:10087418
K A Oriel, E M Hartenbach, P L Remington
CONCLUSION: The trends in ovarian cancer mortality among younger and older women parallel published changes in incidence and may be due to changes in risk factors, such as the use of oral contraceptives. The reasons for the higher ovarian cancer death rates in northern states are unknown. Better understanding of how modifiable risk factors and treatment methods affect ovarian cancer mortality trends is needed.
Published: 01/23/1999
Obstetrics and gynecology pmid:9916951
E M Hartenbach, T A Olson, J J Goswitz, D Mohanraj, L B Twiggs, L F Carson, S Ramakrishnan
Vascular endothelial growth factor (VEGF) expression and microvessel density were studied in cases of advanced epithelial ovarian carcinoma to evaluate their usefulness as prognostic variables. Tumor samples from 18 patients with advanced stage serous epithelial ovarian cancer were evaluated for VEGF expression by reverse-transcriptase polymerase chain reaction (RT-PCR) analysis. Immunohistochemical study of corresponding archival tissues with an antibody to von Willebrand factor (vWF; FVIII-RA)...
Published: 05/07/1998
Cancer letters pmid:9570355
E M Hartenbach, J C Schink
The discovery and sequencing of the BRCA1 gene is an exciting breakthrough for women and health care providers. BRCA1 is associated with inherited breast and ovarian cancer and the body of scientific information regarding its role in ovarian cancer is growing rapidly. The impact of this knowledge on counseling women with a family history of breast or ovarian cancer is profound. This review provides information about familial ovarian cancer syndromes and the emerging role of genetic testing in...
Published: 10/01/1996
Current opinion in obstetrics & gynecology pmid:8941429
E M Hartenbach, J M Fowler
The potential applications of operative laparoscopy have expanded with improvements in technology and instrumentation. With newly developed techniques to complete both pelvic and paraaortic lymph node dissection, the use of the laparoscope has increased in patients with pelvic malignancies. Gynecologic oncologists are currently incorporating the techniques of operative laparoscopy in the management of patients with cervical, endometrial, and ovarian cancer. Multicenter prospective clinical...
Published: 01/01/1996
Diagnostic and therapeutic endoscopy pmid:18493402
E M Hartenbach, A K Saltzman, J R Carter, J M Fowler, D W Hunter, J W Carlson, L B Twiggs, L F Carson
Urinary diversion with creation of a continent ileocolonic reservoir was performed in 25 patients with gynecological malignancies at our institution between September 1989 and September 1994. A retrospective review was conducted and cases were analyzed for functional complications associated with reservoir formation. Functional reservoir complications were defined as (1) difficulty with catheterization, (2) reservoir fistulae, (3) reservoir stones, and (4) ureteral stenosis. Management...
Published: 12/01/1995
Gynecologic oncology pmid:8522255
J W Carlson, A K Saltzman, J R Carter, E M Hartenbach, P R Johnson, M D Chen, L F Carson, L B Twiggs
The development of a carcinoma in a neovagina is rare. Most neovaginal neoplasias have been carcinomas in situ in the skin graft. To date, there has not been a report of a neovaginal carcinoma in a myocutaneous flap. This report is the first of a squamous cell carcinoma arising in a neovagina constructed from a rectus abdominis myocutaneous flap.
Published: 10/01/1995
Gynecologic oncology pmid:7557605
A K Saltzman, J R Carter, J M Fowler, J W Carlson, E M Hartenbach, S E Julian, L F Carson, L B Twiggs
The American Cancer Society (ACS) recommends that asymptomatic women, age 50 and over, undergo sigmoidoscopy every 3 to 5 years, after two negative yearly exams. Epidemiologic evidence suggests that women with gynecologic or breast cancers have an increased risk of developing colon cancer. It is unclear whether the ACS guidelines are applicable for women with a new diagnosis of gynecologic malignancy. This retrospective study was undertaken to assess the usefulness of preoperative colonoscopy in...
Published: 02/01/1995
Gynecologic oncology pmid:7896182
E M Hartenbach, A K Saltzman, J R Carter, L B Twiggs
EMA/CO (etoposide-methotrexate-actinomycin D and Cytoxan-Oncovin) is an effective and well-tolerated chemotherapy regimen for the treatment of high-risk gestational trophoblastic disease. However, it is associated with significant neutropenia often requiring dose reductions and treatment delays. We describe the use of granulocyte colony-stimulating factor (G-CSF) in three patients in order to maintain the treatment schedule. A subcutaneous injection of 5 micrograms/kg/day was administered on...
Published: 01/01/1995
Gynecologic oncology pmid:7529741
J R Carter, M Lau, A K Saltzman, E M Hartenbach, M D Chen, P R Johnson, J M Fowler, J W Carlson, L F Carson, L B Twiggs
The aim of this study was to investigate gray scale and color flow characteristics of a group of patients with a suspected uterine pathologic condition. One hundred and twenty-two consecutive patients at the Women's Cancer Center, University of Minnesota, undergoing transvaginal sonography and color flow Doppler imaging for suspected uterine corpus abnormality made up the study group. After gray scale morphologic assessment, color flow Doppler imaging of the tumor and uterus was performed,...
Published: 11/01/1994
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine pmid:7837328
J M Fowler, E M Hartenbach, H T Reynolds, J Borner, J R Carter, J W Carlson, L B Twiggs, L F Carson
Compared to extraperitoneal laparotomy, the transperitoneal approach is associated with increased enteric morbidity. Recently, transperitoneal laparoscopy has been employed as a method to surgically stage patients with gynecologic malignancies. The objective of this study was to investigate pelvic adhesion formation in a porcine model after pelvic lymphadenectomy performed via transperitoneal laparoscopy (LS) compared to extraperitoneal laparotomy (EP). Ten adult, female hogs underwent LS and 10...
Published: 10/01/1994
Gynecologic oncology pmid:7959261
M J Sammarco, E M Hartenbach, V J Hunter
Forty-five patients were evaluated in a prospective, randomized study to determine the effectiveness of a local injection of lidocaine in reducing pain during cervical cryosurgery. Study patients received a submucosal cervical injection of 1% lidocaine with a 1:100,000 dilution of epinephrine. Control patients did not receive an injection. Both groups received a single dose of naproxen sodium or ketoprofen prior to the procedure. The patient and the observing nurse recorded the pain experienced...
Published: 03/01/1993
The Journal of reproductive medicine pmid:8487231