Portrait of Ellen M. Hartenbach
Ellen M. Hartenbach, MD
Department Chairperson, Professor, Ben Miller Peckham, MD, PhD Chair of Obstetrics and Gynecology
Administration
Gynecologic Oncology

Office Address

McConnell Hall, 4th Floor

Clinic Address

Gynecology Oncology Clinic
600 Highland Ave
Madison, WI, 53705
Phone: 608-265-1700

Administrative Assistant

Ellen M. Hartenbach, MD is the Ben Miller Peckham, MD, PhD, Chair of the Department of Obstetrics and Gynecology and a Professor in the Division of Gynecologic Oncology at the University of Wisconsin-Madison (UW) School of Medicine and Public Health.

Dr. Hartenbach attended medical school at the University of Missouri in Columbia, MO and continued on to complete her residency in Obstetrics and Gynecology at the University of Missouri in Kansas City, MO. She then completed a Fellowship in Gynecologic Oncology at the University of Minnesota. The UW recruited her to join the Department of Obstetrics and Gynecology in 1995.

During her time at the UW, Dr. Hartenbach has held many leadership roles. She previously served as the Vice Chair of Education and Faculty Development from 2007-2022, and accepted the role of Residency Director in 2013, serving in that capacity until 2018. Dr. Hartenbach was the Director of the Division of Gynecologic Oncology from 2000-2006. She also served as the Interim Chair of Obstetrics and Gynecology from 2006-2007.

Dr. Hartenbach has an unfaltering commitment to the delivery of compassionate comprehensive care to women with gynecologic cancers and to the development and refinement of strategies that not only improve the quality of care, but also quality of life options, including end of life palliative care choices. Dr. Hartenbach earned a specialty certificate in Hospice and Palliative Medicine in 2012. Dr. Hartenbach is a national expert in several areas of Gynecologic Oncology, with expertise in chemotherapeutic management of gynecologic malignancies. She has authored over eighty publications and is regularly invited to speak to national audiences. Dr. Hartenbach has served as Principal Investigator or Co-Investigator on numerous grants and clinical trials from various organizations, including the National Institute of Health and industry sponsors. She currently directs the UW Carbone Cancer Center’s Gynecologic Oncology Disease-Oriented Team, which aims to translate scientific discoveries to patient care.

While she has a significant history of research funding and serves as a reviewer for multiple journals, she is also enthusiastic about ensuring the best educational opportunities are available to our current and future physicians. During her time at UW, Dr. Hartenbach has created unique training programs. In 2007, she created the first Ob-Gyn Women and Infants Simulation Center, directing daily operations and creating related curriculum over the first five years. In 2015, Dr. Hartenbach obtained grant funding to start the first rural residency track in the specialty of Obstetrics and Gynecology in the country. Dr. Hartenbach was instrumental in building a robust faculty development platform that includes a Faculty Development Series, Faculty Mentoring and Promotions Program, and Faculty Development Funding Program. She formed the Ob-Gyn Faculty Development Committee, which develops the content for the semi-annual Faculty Development Series tailored to our Ob-Gyn faculty. She led the writing and production of an Ob-Gyn Faculty Mentoring and Promotions Handbook, adapted by several others for use in their respective departments at UW.

In addition to her research, education, and leadership activities, Dr. Hartenbach is the consummate physician and has been recognized many times, most recently as a Patient Experience Physician Champion in 2013, 2016, and 2019. Her clinical and educational expertise enabled her to serve as an American Board of Obstetrics and Gynecology Board Examiner for General Obstetrics and Gynecology for over a decade.  She has served on enumerable committees in national professional organizations, most notably as a current member of the Society of Gynecologic Oncology Clinical Practice Committee and the National Cancer Institute NRG Ovarian Committee.

B.A. University of Detroit, Detroit, MI
M.D. University of Missouri, Columbia, MO
Residency University of Missouri, Kansas City, MO
Fellowship University of Minnesota, Minneapolis, MN

American Board of Obstetrics and Gynecology

Obstetics & Gynecology, Gynecologic Oncology, Palliatve Medicine

UW Health Patient and Family Experience Promise Recognition Award, 2019

Wisconsin Medical Society

Fellow, American College of Obstetrics and Gynecology (ACOG)

Society of Gynecologic Oncology (SGO)


Incidence of postoperative venous thromboembolism in patients with vulvar carcinoma undergoing vulvectomy with or without lymphadenectomy

Matthew K Wagar, Aaditi Naik, Ran Catherine Zhang, Amy Godecker, Ellen M Hartenbach, Janelle N Sobecki, Sumer K Wallace

CONCLUSIONS: The incidence of postoperative VTE is low in patients undergoing radical vulvar surgery in this national cohort. Inguinofemoral lymph node dissection by any method does not appear to be a risk factor for VTE when compared to radical vulvectomy alone. Further research is needed to determine if extended VTE prophylaxis is beneficial in this population.

Published: 05/25/2024

Gynecologic oncology pmid:38795507

TP53 mutations and the association with platinum resistance in high grade serous ovarian carcinoma

Lauren Montemorano, Zoey B Shultz, Alma Farooque, Meredith Hyun, Richard J Chappell, Ellen M Hartenbach, Jessica D Lang

CONCLUSIONS: TP53 hotspot mutations or high pathogenicity scores were not associated with platinum resistance or refractory disease. Contrary to prior studies, TP53 gain-of-function mutations were not associated with platinum resistance. Estimation of TP53 gain-of-function effect using missense mutation phenotype scores was not associated with platinum resistance. The polymorphic nature of TP53 mutations may be too complex to demonstrate effect using simple models, or response to platinum...

Published: 03/31/2024

Gynecologic oncology pmid:38555766

The role of ctDNA in endometrial cancer: A tool for risk stratification and disease monitoring

Grace C Blitzer, Shuang G Zhao, Kristin A Bradley, Ellen M Hartenbach

No abstract

Published: 08/30/2023

Gynecologic oncology pmid:37648640

Phase III Trial of Carboplatin and Paclitaxel Compared With Cisplatin and Paclitaxel in Patients With Optimally Resected Stage III Ovarian Cancer: A Gynecologic Oncology Group Study

Robert F Ozols, Brian N Bundy, Benjamin E Greer, Jeffrey M Fowler, Daniel Clarke-Pearson, Robert A Burger, Robert S Mannel, Koen DeGeest, Ellen M Hartenbach, Rebecca Baergen

Purpose: In randomized trials the combination of cisplatin and paclitaxel was superior to cisplatin and cyclophosphamide in advanced-stage epithelial ovarian cancer. Although in nonrandomized trials, carboplatin and paclitaxel was a less toxic and highly active combination regimen, there remained concern regarding its efficacy in patients with small-volume, resected, stage III disease. Thus, we conducted a noninferiority trial of cisplatin and paclitaxel versus carboplatin and paclitaxel in this...

Published: 08/29/2023

Journal of clinical oncology : official journal of the American Society of Clinical Oncology pmid:37643542

Beyond post-operative readmissions: analysis of the impact of unplanned readmissions during primary treatment of advanced-stage epithelial ovarian cancer on long-term oncology outcome

Dandi Huang, Ross Harrison, Erin Curtis, Nina Mirabadi, Grace Yi Chen, Roxana Alexandridis, Lisa Barroilhet, Stephen Rose, Ellen Hartenbach, Ahmed Al-Niami

CONCLUSIONS: In this study, 35% of the women with advanced ovarian cancer had at least one unplanned readmission during the entire treatment time. Patients treated by primary cytoreductive surgery spent more days during readmission than those with neoadjuvant chemotherapy. Readmissions did not affect progression-free survival and may not be valuable as a quality metric.

Published: 02/22/2023

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:36808044

Opportunistic osteoporosis screening using routine computed tomography images to identify bone loss in gynecologic cancer survivors

Janelle Sobecki, Benjamin Weigman, India Anderson-Carter, Lisa Barroilhet, Thevaa Chandereng, Mark Kliewer, Ellen Hartenbach

CONCLUSIONS: Women with gynecologic cancers may experience accelerated cancer treatment-induced bone loss. Routine CT imaging is a convenient screening modality to identify those at highest risk for osteoporosis who warrant further evaluation with dual-energy X-ray absorptiometry. Routine bone mineral density assessments 1 year following oophorectomy for cancer treatment may be warranted in this population.

Published: 02/01/2022

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:35101963

Postoperative venous thromboembolism in gynecologic oncology patients undergoing minimally invasive surgery: Does modality matter?

Matthew K Wagar, Janelle N Sobecki, Thevaa Chandereng, Ellen M Hartenbach, Sumer K Wallace

CONCLUSIONS: The incidence of postoperative VTE in patients with gynecologic cancers undergoing MIS is low and does not appear to differ by MIS modality. Given the very low incidence of postoperative VTE, extended chemoprophylaxis is unlikely to benefit patients with gynecologic malignancies undergoing MIS procedures.

Published: 06/21/2021

Gynecologic oncology pmid:34148718

Top Ten Tips Palliative Care Clinicians Should Know About Caring for Patients with Cervical Cancer

Claire Hoppenot, Ramey D Littell, Timothy DeEulis, Ellen M Hartenbach

Cervical cancer is the most common gynecologic cancer worldwide. Almost all are related to human papillomavirus exposure. Cervical cancer treatment is associated with significant morbidity that is likely to require support from palliative care teams. In these pearls on cervical cancer, we hope to inform providers about the common treatments and issues for cervical cancer patients. Treatment modalities include surgery for early-stage disease, radiation therapy for locally advanced disease, and...

Published: 01/29/2021

Journal of palliative medicine pmid:33513069

Bone health and osteoporosis screening in gynecologic cancer survivors

Janelle N Sobecki, Laurel W Rice, Ellen M Hartenbach

Cancer treatment-induced bone loss is a known side effect of cancer therapy that increases the risk of osteoporosis and bone fracture. Women with gynecologic cancer are at increased risk of bone loss secondary to the combined effect of oophorectomy and adjuvant therapies. Data regarding bone loss in women with gynecologic cancers are overall lacking compared to other cancer populations. Consequently, guidelines for osteoporosis screening in women with cancer are largely based on data generated...

Published: 12/14/2020

Gynecologic oncology pmid:33309416

Peripartum Blood Transfusion Among Rural Women in the United States

Ellen M Hartenbach, Hsiang-Hui Daphne Kuo, Madelyne Z Greene, Emily A Shrider, Kathleen M Antony, Deborah B Ehrenthal

CONCLUSION: The odds of blood transfusion were higher for women in rural areas. The results indicate that the rurality of the county where the birth occurred was associated with more transfusion. This may reflect differences in maternity and blood banking services in rural hospitals and warrants further study to identify opportunities for intervention.

Published: 02/07/2020

Obstetrics and gynecology pmid:32028506

Preoperative obstructive sleep apnea screening in gynecologic oncology patients

Ross F Harrison, Erin E Medlin, Chase B Petersen, Stephen L Rose, Ellen M Hartenbach, David M Kushner, Ryan J Spencer, Laurel W Rice, Ahmed N Al-Niaimi

CONCLUSION: The prevalence of obstructive sleep apnea or screening at risk for the condition is high among women presenting for surgery with a gynecologic oncologist. Providers should consider evaluating a patient's risk for obstructive sleep apnea in the preoperative setting, especially when risk factors for the condition are present.

Published: 05/25/2018

American journal of obstetrics and gynecology pmid:29792853

Women's Health Care in Wisconsin: A Closer Look

Jody Silva, Ellen Hartenbach, Robert N Golden

No abstract

Published: 01/23/2018

WMJ : official publication of the State Medical Society of Wisconsin pmid:29357213

Impact of histology and surgical approach on survival among women with early-stage, high-grade uterine cancer: An NRG Oncology/Gynecologic Oncology Group ancillary analysis

Amanda N Fader, James Java, Meaghan Tenney, Stephanie Ricci, Camille C Gunderson, Sarah M Temkin, Nick Spirtos, Christina L Kushnir, Michael L Pearl, Oliver Zivanovic, Krishnansu S Tewari, David O'Malley, Ellen M Hartenbach, Chad A Hamilton, Natalie S Gould, Robert S Mannel, William Rodgers, Joan L Walker

CONCLUSIONS: Women with apparent early-stage, USC and CS histologies have poorer outcomes than women with grade 3 endometrioid adenocarcinoma. Patterns of recurrence and survival were not impacted by surgical approach.

Published: 10/17/2016

Gynecologic oncology pmid:27743738

Maintaining sexual health throughout gynecologic cancer survivorship: A comprehensive review and clinical guide

Laura B Huffman, Ellen M Hartenbach, Jeanne Carter, Joanne K Rash, David M Kushner

CONCLUSION: Oncology providers can make a significant impact on the QoL of gynecologic cancer survivors by addressing sexual health concerns. Simple strategies can be implemented into clinical practice to discuss and treat many sexual issues. Referral to specialized sexual health providers may be needed to address more complex problems.

Published: 11/12/2015

Gynecologic oncology pmid:26556768

Thrombocytosis is Predictive of Postoperative Pulmonary Embolism in Patients With Gynecologic Cancer

Cassandra L Albertin, Shitanshu Uppal, Ahmed N Al-Niaimi, Songwon Seo, James Louis Hinshaw, Ellen M Hartenbach

CONCLUSIONS: Although clinicians often use tachycardia and low oxygen saturation as triggers to order PE imaging studies, these signs have a very low specificity. Given the findings of our study, accounting for high platelet count and history of VTE increases the pretest probability of CT-PA study.

Published: 06/23/2015

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:26098091

Dynamic and quasi-static mechanical testing for characterization of the viscoelastic properties of human uterine tissue

Eenas A Omari, Tomy Varghese, Mark A Kliewer, Josephine Harter, Ellen M Hartenbach

Ultrasound elastography is envisioned as an optional modality to augment standard ultrasound B-mode imaging and is a promising technique to aid in detecting uterine masses which cause abnormal uterine bleeding in both pre- and post-menopausal women. In order to determine the effectiveness of strain imaging, mechanical testing to establish the elastic contrast between normal uterine tissue and stiffer masses such as leiomyomas (fibroids) and between softer pathologies such as uterine cancer and...

Published: 06/15/2015

Journal of biomechanics pmid:26072212

Intensive postoperative glucose control reduces the surgical site infection rates in gynecologic oncology patients

Ahmed N Al-Niaimi, Mostafa Ahmed, Nikki Burish, Saygin A Chackmakchy, Songwon Seo, Stephen Rose, Ellen Hartenbach, David M Kushner, Nasia Safdar, Laurel Rice, Joseph Connor

CONCLUSIONS: Initiating intensive glycemic control for 24h after gynecologic oncology surgery in patients with DM and postoperative hyperglycemia lowers the SSI rate by 35% (OR = 0.5) compared to patients receiving intermittent sliding scale insulin and to a rate equivalent to non-diabetics.

Published: 09/30/2014

Gynecologic oncology pmid:25263249

Preoperative hypoalbuminemia is an independent predictor of poor perioperative outcomes in women undergoing open surgery for gynecologic malignancies

Shitanshu Uppal, Ahmed Al-Niaimi, Laurel W Rice, Stephen L Rose, David M Kushner, Ryan J Spencer, Ellen Hartenbach

CONCLUSION: Preoperative albumin levels <3g/dL identify a population of patients at a very high-risk of experiencing perioperative morbidity and 30-day mortality after open surgery.

Published: 08/22/2013

Gynecologic oncology pmid:23962700

A new diagnostic test for endometrial cancer?: Cytology analysis of sonohysterography distention media

Onur Guralp, Susan M Sheridan, Josephine Harter, James Louis Hinshaw, Songwon Seo, Ellen M Hartenbach, Steven Lindheim, Sarah Stewart, David M Kushner

CONCLUSIONS: Most patients with early endometrial cancer can undergo SIS procedures with adequate cytology specimens obtained from distention media. However, the sensitivity is low, and refinements are necessary before utilizing as a diagnostic test. In cases with positive results, the patient may be able to avoid other costly and painful procedures.

Published: 07/25/2013

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:23881100

Prolonged postoperative venous thrombo-embolism prophylaxis is cost-effective in advanced ovarian cancer patients

Shitanshu Uppal, Enrique Hernandez, Moushumi Dutta, Vani Dandolu, Stephen Rose, Ellen Hartenbach

CONCLUSIONS: In ovarian cancer patients undergoing open abdominal surgery, prolonged VTE prophylaxis not only improves patient outcomes, but is also a cost saving strategy when modeled over five years. A significant reduction in the episodes of VTE and a higher overall survival warrants consideration for the routine use of PP in this patient population.

Published: 09/04/2012

Gynecologic oncology pmid:22940486

Compression-dependent viscoelastic behavior of human cervix tissue

Ryan J DeWall, Tomy Varghese, Mark A Kliewer, Josephine M Harter, Ellen M Hartenbach

We have characterized the viscoelastic properties of human cervical tissue through a range of precompressional loads and testing frequencies. Mechanical testing is necessary to develop robust elasticity-based techniques for the diagnosis of cervical abnormalities. The storage modulus (E') and material damping (tan 6) were measured in 13 patients, 40 to 76 years old. Our results showed that E' increased monotonically from approximately 4.7 to 6.3 kPa over the precompression range (1-6%) for a...

Published: 01/11/2011

Ultrasonic imaging pmid:21213567

Uterine artery sparing robotic radical trachelectomy (AS-RRT) for early cancer of the cervix

Ahmed N Al-Niaimi, Margaret H Einstein, LaToya Perry, Ellen M Hartenbach, David M Kushner

CONCLUSION: Technically, the surgery is feasible and could be performed by any gynecologic oncologist who is skilled in radical pelvic surgery and the robotic system. The long-term obstetric and oncologic outcome of this technique would be expected to match the outcome of the other radical trachelectomy techniques in the published literature, but is yet to be fully elucidated.

Published: 10/16/2010

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics pmid:20947081

Sunitinib malate in the treatment of recurrent or persistent uterine leiomyosarcoma: a Gynecologic Oncology Group phase II study

Martee L Hensley, Michael W Sill, Dennis R Scribner, Jubilee Brown, Robert L Debernardo, Ellen M Hartenbach, Carolyn K McCourt, James R Bosscher, Paola A Gehrig

CONCLUSION: Sunitinib fails to achieve sufficient objective response or sustained disease stabilization as second- or third-line treatment for uterine leiomyosarcoma.

Published: 10/09/2009

Gynecologic oncology pmid:19811811

Brief report: Measuring the attitudes of health care professionals in Dane County toward adolescent immunization with HPV vaccine

Megan E Jensen, Ellen Hartenbach, Jane A McElroy, Adrienne Faerber, Thomas Havighurst, Kyung Mann Kim, Howard H Bailey

CONCLUSION: Health care professionals in family medicine, pediatrics, and gynecology in Dane County, Wis, have positive attitudes regarding HPV vaccine recommendation for their adolescent patients.

Published: 09/17/2009

WMJ : official publication of the State Medical Society of Wisconsin pmid:19753828

Outcomes following surgery and adjuvant radiation in stage II endometrial adenocarcinoma

G M Cannon, H Geye, B E Terakedis, D M Kushner, J P Connor, E M Hartenbach, K A Bradley

PURPOSE: To evaluate locoregional control, disease free survival, and overall survival in patients treated with surgery and adjuvant radiation for stage II adenocarcinoma of the endometrium. Secondary goals include identification of prognostic factors and the comparison of toxicity profiles after vaginal cuff brachytherapy (VB) alone or combined with pelvic external beam radiation therapy (EXT).

Published: 02/17/2009

Gynecologic oncology pmid:19217147

A protocol of dual prophylaxis for venous thromboembolism prevention in gynecologic cancer patients

M Heather Einstein, David M Kushner, Joseph P Connor, Alex A Bohl, Thomas J Best, Michael D Evans, Richard J Chappell, Ellen M Hartenbach

CONCLUSION: A protocol of dual prophylaxis with prolonged prophylaxis in high-risk patients was successfully implemented and was associated with a significant reduction in the rate of venous thromboembolism without increasing bleeding complications.

Published: 11/04/2008

Obstetrics and gynecology pmid:18978110

Phase I trial of the treatment of high-risk endometrial cancer with concurrent weekly paclitaxel and cisplatin and whole abdominal radiation therapy: a Gynecologic Oncology Group study

D Scott McMeekin, Joan L Walker, Ellen M Hartenbach, Michael A Bookman, Wui-Jin Koh, Gynecologic Oncology Group

CONCLUSION: A regimen of cisplatin 25 mg/m(2) and paclitaxel 20 mg/m(2) weekly with WART was determined to be feasible, but is associated with moderate acute and chronic gastrointestinal toxicity.

Published: 10/31/2008

Gynecologic oncology pmid:18962846

The effect of laparoscopic guidance on gynecologic interstitial brachytherapy

David B Engle, Kristin A Bradley, Rick J Chappell, Joseph P Conner, Ellen M Hartenbach, David M Kushner

CONCLUSION: The LAIB procedure appears safe, but substantially increases operating department time. No significant decrease in late high-grade toxicities were detected in comparison with TrIB. The LAIB procedure allows for both lysis of adhesions and identification of unknown carcinomatosis.

Published: 07/29/2008

Journal of minimally invasive gynecology pmid:18657479

Sonohysterography and endometrial cancer: incidence and functional viability of disseminated malignant cells

Emily Berry, Steven R Lindheim, Joseph P Connor, Ellen M Hartenbach, Julian C Schink, Josephine Harter, Jens C Eickhoff, David M Kushner

CONCLUSION: Transtubal spill occurs during sonohysterography. No critical spill volume was identified. A highly diagnostic tool when abnormal bleeding is evaluated, sonohysterography has a low probability of cancer cell dissemination.

Published: 05/06/2008

American journal of obstetrics and gynecology pmid:18456240

Venous thromboembolism prophylaxis: is two better than one?

M Heather Einstein, Ellen M Hartenbach

No abstract

Published: 09/01/2007

Gynecologic oncology pmid:17761279

In vitro uterine strain imaging: preliminary results

Maritza A Hobson, Miklos Z Kiss, Tomy Varghese, Amy M Sommer, Mark A Kliewer, James A Zagzebski, Timothy J Hall, Josephine Harter, Ellen M Hartenbach, Ernest L Madsen

CONCLUSIONS: Ultrasound strain imaging can differentiate between endometrial polyps and leiomyomas. More data are necessary to validate these results and to ascertain whether other uterine abnormalities can also be differentiated.

Published: 06/27/2007

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine pmid:17592053

Laparoscopic sentinel lymph node mapping for cervix cancer--a detailed evaluation and time analysis

David M Kushner, Joseph P Connor, Michael A Wilson, G Reza Hafez, Richard J Chappell, Sarah L Stewart, Ellen M Hartenbach

CONCLUSIONS: Laparoscopic SLN mapping can be newly introduced into gynecologic oncology centers with high detection rates and negative predictive values. The visualization of blue dye in SLNs is transient, and this negative time correlation may explain the previously reported inferior detection rates with this technique. CLINICAL TRIAL REGISTRATION.: ClinicalTrials.gov, http://www.clinicaltrials.gov, NCT 00205010.

Published: 06/15/2007

Gynecologic oncology pmid:17560635

Venous thromboembolism prevention in gynecologic cancer surgery: a systematic review

M Heather Einstein, Elizabeth A Pritts, Ellen M Hartenbach

CONCLUSIONS: All gynecologic cancer patients should receive VTE prophylaxis. Although heparin, LMWH, and SCD have been shown to be safe and effective, due to the paucity of data in the gynecologic oncology literature, no one prevention modality can be considered superior at this time. Adequately powered RCTs are urgently needed to determine the optimal regimen in these high-risk patients.

Published: 04/24/2007

Gynecologic oncology pmid:17449089

Weekly docetaxel and carboplatin for recurrent ovarian and peritoneal cancer: a phase II trial

David M Kushner, Joseph P Connor, Federico Sanchez, Michael Volk, Julian C Schink, Howard H Bailey, Linda S Harris, Sarah L Stewart, Jason Fine, Ellen M Hartenbach, Wisconsin Oncology Network

CONCLUSION: The weekly regimen of carboplatin and docetaxel has a good response rate with an acceptable toxicity profile.

Published: 01/30/2007

Gynecologic oncology pmid:17258800

Frequency-dependent complex modulus of the uterus: preliminary results

Miklos Z Kiss, Maritza A Hobson, Tomy Varghese, Josephine Harter, Mark A Kliewer, Ellen M Hartenbach, James A Zagzebski

The frequency-dependent complex moduli of human uterine tissue have been characterized. Quantification of the modulus is required for developing uterine ultrasound elastography as a viable imaging modality for diagnosing and monitoring causes for abnormal uterine bleeding and enlargement, as well assessing the integrity of uterine and cervical tissue. The complex modulus was measured in samples from hysterectomies of 24 patients ranging in age from 31 to 79 years. Measurements were done under...

Published: 07/25/2006

Physics in medicine and biology pmid:16861774

Patient-provider communication and perceived control for women experiencing multiple symptoms associated with ovarian cancer

Heidi Scharf Donovan, Ellen M Hartenbach, Michael W Method

CONCLUSIONS: Women with ovarian cancer experience multiple symptoms, but many do not discuss symptoms with their HCPs and fewer report receiving symptom management recommendations. Women would benefit from more active symptom assessment and discussion of management strategies by HCPs.

Published: 08/23/2005

Gynecologic oncology pmid:16112174

Use of a bupivacaine continuous wound infusion system in gynecologic oncology: a randomized trial

David M Kushner, Regina LaGalbo, Joseph P Connor, Rick Chappell, Sarah L Stewart, Ellen M Hartenbach

CONCLUSION: The results suggest that although the continuous infusion system seems safe, it is not efficacious in this patient population.

Published: 08/02/2005

Obstetrics and gynecology pmid:16055569

Implications of second-look laparotomy in the context of optimally resected stage III ovarian cancer: a non-randomized comparison using an explanatory analysis: a Gynecologic Oncology Group study

Benjamin E Greer, Brian N Bundy, Robert F Ozols, Jeffrey M Fowler, Daniel Clarke-Pearson, Robert A Burger, Robert Mannel, Koen DeGeest, Ellen M Hartenbach, Rebecca N Baergen, Larry J Copeland

CONCLUSION: In the context of a non-randomized comparison, the performance of a SLL was not associated with longer survival.

Published: 07/26/2005

Gynecologic oncology pmid:16039699

Long-term complications associated with the Indiana pouch urinary diversion in patients with recurrent gynecologic cancers after high-dose radiation

Michael Wilkin, Greg Horwitz, Anil Seetharam, Ellen Hartenbach, Julian C Schink, Reginald Bruskewitz, David F Jarrard

Few studies have assessed the long-term risks associated with the Indiana pouch continent urinary diversion after high-dose radiation therapy. A retrospective review of consecutive female patients who underwent cystectomy and Indiana pouch urinary diversion identified 12 with a history of high-dose pelvic irradiation (mean total 78.1 Gy). Long-term complications and outcomes in this group were compared to a synchronous group of patients (n = 14) with no history of radiation. Mean follow-up in...

Published: 05/12/2005

Urologic oncology pmid:15885577

Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study

Robert F Ozols, Brian N Bundy, Benjamin E Greer, Jeffrey M Fowler, Daniel Clarke-Pearson, Robert A Burger, Robert S Mannel, Koen DeGeest, Ellen M Hartenbach, Rebecca Baergen, Gynecologic Oncology Group

CONCLUSION: In patients with advanced ovarian cancer, a chemotherapy regimen consisting of carboplatin plus paclitaxel results in less toxicity, is easier to administer, and is not inferior, when compared with cisplatin plus paclitaxel.

Published: 07/16/2003

Journal of clinical oncology : official journal of the American Society of Clinical Oncology pmid:12860964

Progress of a Comprehensive Familial Cancer Genetic Counseling Program in the Era of BRCA1 and BRCA2

Ellen M Hartenbach, Joanne M Becker, Elizabeth A Grosen, Howard H Bailey, Daniel G Petereit, Renata Laxova, Julian C Schink

BRCA1 and BRCA2 mutation carriers have an increased risk of developing breast and/or ovarian cancer. Technical advances in genetic testing have increased the need for genetic counseling services; therefore, we have developed a counseling program for these individuals. The purpose of this study is to characterize this population, assess level of interest in genetic testing, and evaluate our program over a 5-year period. Our Familial Cancer Genetic Counseling Program was established in November,...

Published: 09/17/2002

Genetic testing pmid:12229876

Outpatient vaginal cuff brachytherapy for endometrial cancer

D. G. Petereit, S. P. Tannehill, E. A. Grosen, E. M. Hartenbach, J. C. Schink

Petereit DG, Tannehill SP, Grosen EA, Hartenbach EM, Schink JC. Outpatient vaginal cuff brachytherapy for endometrial cancer. The objective of this study was to determine the efficacy and complications of postoperative high-dose-rate (HDR) vaginal-cuff brachytherapy (VCB) in patients with endometrial carcinoma. Between August 1989 to September 1997, 191 patients were treated postoperatively after a total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH/BSO) with outpatient...

Published: 03/10/2001

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:11240811

Screening for occult nodal metastasis in squamous cell carcinoma of the vulva

C M Leys, E M Hartenbach, G R Hafez, D M Mahvi

Metastases to inguinofemoral lymph nodes in patients with carcinoma of the vulva alter the prognosis and treatment of this disease. Our goal was to determine if immunohistochemical staining could reveal occult metastatic nodal disease not detected with routine hematoxylin and eosin staining. We retrospectively examined a total of 110 lymph nodes from 10 patients who had undergone lymph node dissection and found to have all negative nodes. Paraffin embedded lymph nodes were immunostained with a...

Published: 07/25/2000

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists pmid:10907173

Paclitaxel, carboplatin, and hexamethyl-melamine (taxchex) as first-line therapy for ovarian cancer

E M Hartenbach, L S Harris, H H Bailey, E A Grosen, E Larrison, D Chen, L B Twiggs, J C Schink

CONCLUSION: The addition of hexamethylmelamine to paclitaxel and carboplatin is a well-tolerated multidrug combination for women with advanced ovarian cancer that deserves further testing in a phase III study.

Published: 12/22/1999

The cancer journal from Scientific American pmid:10606476

Familial ovarian germ cell cancer: report and review

A R Stettner, E M Hartenbach, J C Schink, R Huddart, J Becker, R Pauli, R Long, R Laxova

Ovarian germ cell cancers are rare malignancies accounting for less than 5% of all ovarian cancers. We present a family in which three closely related women were diagnosed with ovarian germ cell malignancies. This family's cancer history prompted a family history investigation of women treated for ovarian germ cell malignancies in the Gynecologic-Oncology Clinic at the University of Wisconsin. One of the eight patients whose family histories were reviewed had an uncle who had been diagnosed with...

Published: 04/23/1999

American journal of medical genetics pmid:10213045

Transforming growth factor-alpha levels in the serum and ascites of patients with advanced epithelial ovarian cancer

A K Saltzman, E M Hartenbach, J R Carter, D N Contreras, L B Twiggs, L F Carson, S Ramakrishnan

A variety of cytokines have been identified to play a role in ovarian cancer. In this pilot study, we sought to determine whether transforming growth factor-alpha (TGF-alpha) was detectable in the serum and ascites of women with advanced stage epithelial ovarian cancer. TGF-alpha was measured using an enzyme-linked immunosorbent assay and was present in 18 of 25 control sera. Prior to treatment for stage III or IV epithelial ovarian cancer, 18 patients had undetectable serum levels of TGF-alpha,...

Published: 03/24/1999

Gynecologic and obstetric investigation pmid:10087418

Trends in United States ovarian cancer mortality, 1979-1995

K A Oriel, E M Hartenbach, P L Remington

CONCLUSION: The trends in ovarian cancer mortality among younger and older women parallel published changes in incidence and may be due to changes in risk factors, such as the use of oral contraceptives. The reasons for the higher ovarian cancer death rates in northern states are unknown. Better understanding of how modifiable risk factors and treatment methods affect ovarian cancer mortality trends is needed.

Published: 01/23/1999

Obstetrics and gynecology pmid:9916951

Vascular endothelial growth factor (VEGF) expression and survival in human epithelial ovarian carcinomas

E M Hartenbach, T A Olson, J J Goswitz, D Mohanraj, L B Twiggs, L F Carson, S Ramakrishnan

Vascular endothelial growth factor (VEGF) expression and microvessel density were studied in cases of advanced epithelial ovarian carcinoma to evaluate their usefulness as prognostic variables. Tumor samples from 18 patients with advanced stage serous epithelial ovarian cancer were evaluated for VEGF expression by reverse-transcriptase polymerase chain reaction (RT-PCR) analysis. Immunohistochemical study of corresponding archival tissues with an antibody to von Willebrand factor (vWF; FVIII-RA)...

Published: 05/07/1998

Cancer letters pmid:9570355

The genetics of ovarian cancer: concepts in testing and counseling

E M Hartenbach, J C Schink

The discovery and sequencing of the BRCA1 gene is an exciting breakthrough for women and health care providers. BRCA1 is associated with inherited breast and ovarian cancer and the body of scientific information regarding its role in ovarian cancer is growing rapidly. The impact of this knowledge on counseling women with a family history of breast or ovarian cancer is profound. This review provides information about familial ovarian cancer syndromes and the emerging role of genetic testing in...

Published: 10/01/1996

Current opinion in obstetrics & gynecology pmid:8941429

The role of operative laparoscopy in gynecologic oncology

E M Hartenbach, J M Fowler

The potential applications of operative laparoscopy have expanded with improvements in technology and instrumentation. With newly developed techniques to complete both pelvic and paraaortic lymph node dissection, the use of the laparoscope has increased in patients with pelvic malignancies. Gynecologic oncologists are currently incorporating the techniques of operative laparoscopy in the management of patients with cervical, endometrial, and ovarian cancer. Multicenter prospective clinical...

Published: 01/01/1996

Diagnostic and therapeutic endoscopy pmid:18493402

Nonsurgical management strategies for the functional complications of ileocolonic continent urinary reservoirs

E M Hartenbach, A K Saltzman, J R Carter, J M Fowler, D W Hunter, J W Carlson, L B Twiggs, L F Carson

Urinary diversion with creation of a continent ileocolonic reservoir was performed in 25 patients with gynecological malignancies at our institution between September 1989 and September 1994. A retrospective review was conducted and cases were analyzed for functional complications associated with reservoir formation. Functional reservoir complications were defined as (1) difficulty with catheterization, (2) reservoir fistulae, (3) reservoir stones, and (4) ureteral stenosis. Management...

Published: 12/01/1995

Gynecologic oncology pmid:8522255

Recurrent squamous cell carcinoma in a rectus abdominis neovagina

J W Carlson, A K Saltzman, J R Carter, E M Hartenbach, P R Johnson, M D Chen, L F Carson, L B Twiggs

The development of a carcinoma in a neovagina is rare. Most neovaginal neoplasias have been carcinomas in situ in the skin graft. To date, there has not been a report of a neovaginal carcinoma in a myocutaneous flap. This report is the first of a squamous cell carcinoma arising in a neovagina constructed from a rectus abdominis myocutaneous flap.

Published: 10/01/1995

Gynecologic oncology pmid:7557605

The utility of preoperative screening colonoscopy in gynecologic oncology

A K Saltzman, J R Carter, J M Fowler, J W Carlson, E M Hartenbach, S E Julian, L F Carson, L B Twiggs

The American Cancer Society (ACS) recommends that asymptomatic women, age 50 and over, undergo sigmoidoscopy every 3 to 5 years, after two negative yearly exams. Epidemiologic evidence suggests that women with gynecologic or breast cancers have an increased risk of developing colon cancer. It is unclear whether the ACS guidelines are applicable for women with a new diagnosis of gynecologic malignancy. This retrospective study was undertaken to assess the usefulness of preoperative colonoscopy in...

Published: 02/01/1995

Gynecologic oncology pmid:7896182

A novel strategy using G-CSF to support EMA/CO for high-risk gestational trophoblastic disease

E M Hartenbach, A K Saltzman, J R Carter, L B Twiggs

EMA/CO (etoposide-methotrexate-actinomycin D and Cytoxan-Oncovin) is an effective and well-tolerated chemotherapy regimen for the treatment of high-risk gestational trophoblastic disease. However, it is associated with significant neutropenia often requiring dose reductions and treatment delays. We describe the use of granulocyte colony-stimulating factor (G-CSF) in three patients in order to maintain the treatment schedule. A subcutaneous injection of 5 micrograms/kg/day was administered on...

Published: 01/01/1995

Gynecologic oncology pmid:7529741

Gray scale and color flow Doppler characterization of uterine tumors

J R Carter, M Lau, A K Saltzman, E M Hartenbach, M D Chen, P R Johnson, J M Fowler, J W Carlson, L F Carson, L B Twiggs

The aim of this study was to investigate gray scale and color flow characteristics of a group of patients with a suspected uterine pathologic condition. One hundred and twenty-two consecutive patients at the Women's Cancer Center, University of Minnesota, undergoing transvaginal sonography and color flow Doppler imaging for suspected uterine corpus abnormality made up the study group. After gray scale morphologic assessment, color flow Doppler imaging of the tumor and uterus was performed,...

Published: 11/01/1994

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine pmid:7837328

Pelvic adhesion formation after pelvic lymphadenectomy: comparison between transperitoneal laparoscopy and extraperitoneal laparotomy in a porcine model

J M Fowler, E M Hartenbach, H T Reynolds, J Borner, J R Carter, J W Carlson, L B Twiggs, L F Carson

Compared to extraperitoneal laparotomy, the transperitoneal approach is associated with increased enteric morbidity. Recently, transperitoneal laparoscopy has been employed as a method to surgically stage patients with gynecologic malignancies. The objective of this study was to investigate pelvic adhesion formation in a porcine model after pelvic lymphadenectomy performed via transperitoneal laparoscopy (LS) compared to extraperitoneal laparotomy (EP). Ten adult, female hogs underwent LS and 10...

Published: 10/01/1994

Gynecologic oncology pmid:7959261

Local anesthesia for cryosurgery on the cervix

M J Sammarco, E M Hartenbach, V J Hunter

Forty-five patients were evaluated in a prospective, randomized study to determine the effectiveness of a local injection of lidocaine in reducing pain during cervical cryosurgery. Study patients received a submucosal cervical injection of 1% lidocaine with a 1:100,000 dilution of epinephrine. Control patients did not receive an injection. Both groups received a single dose of naproxen sodium or ketoprofen prior to the procedure. The patient and the observing nurse recorded the pain experienced...

Published: 03/01/1993

The Journal of reproductive medicine pmid:8487231

Dr. Hartenbach's Research Focus

Focus: Dr. Hartenbach has acted as Principal Investigator or Co-Investigator on over 15 grants from various organizations, including the National Institute of Health (NIH). She is also an avid journal reviewer to ensure quality research is disseminated appropriately to health care providers. She has authored or co-authored over 60 peer reviewed journal articles and has co-authored two book chapters. She is the Director of Gynecology Oncology Clinical Research at the UW Carbone Cancer Center. Her research involves gynecologic cancer clinical trials, as well as the broader reproductive health issues of access to care and disparities in women’s health care.

Edit profile