Importance Of Endothelial Cell-Cell Communication At The Maternal Fetal Interface Test

08/15/2013 - 06/30/2019

Sponsor: NIH P01 HD038843- (Bird-PI)

Status: Completed

This proposal studies cell cell communication in uterine and umbilical vascular endothelium in pregnancy and the role of kinase activation in regulating those processes in preeclampsia.

Publications:

Zhou C, Yan Q, Zou QY, Zhong XQ, Tyler CT, Magness RR, Bird IM, Zheng J. Sexual Dimorphisms of Preeclampsia-Dysregulated Transcriptomic Profiles and Cell Function in Fetal Endothelial Cells. Hypertension. 2019 Jul;74(1):154-163. doi: 10.1161/HYPERTENSIONAHA.118.12569. Epub 2019 Jun 3. PubMed PMID: 31154903; PubMed Central PMCID: PMC6561818.

Ampey AC, Boeldt DS, Clemente L, Grummer MA, Yi F, Magness RR, Bird IM. TNF-alpha inhibits pregnancy-adapted Ca(2+) signaling in uterine artery endothelial cells. Mol Cell Endocrinol. 2019 May 15;488:14-24. doi: 10.1016/j.mce.2019.02.008. Epub 2019 Feb 16. PubMed PMID: 30779937; PubMed Central PMCID: PMC6475486.

Zou QY, Zhao YJ, Zhou C, Liu AX, Zhong XQ, Yan Q, Li Y, Yi FX, Bird IM, Zheng J. G Protein α Subunit 14 Mediates Fibroblast Growth Factor 2-Induced Cellular Responses in Human Endothelial Cells. J Cell Physiol. 2019 Jul;234(7):10184-10195. doi: 10.1002/jcp.27688. Epub 2018 Nov 1. PubMed PMID: 30387149; PubMed Central PMCID: PMC6426666.

Ampey BC, Ampey AC, Lopez GE, Bird IM, Magness RR. Cyclic Nucleotides Differentially Regulate Cx43 Gap Junction Function in Uterine Artery Endothelial Cells From Pregnant Ewes. Hypertension. 2017 Aug;70(2):401-411. doi: 10.1161/HYPERTENSIONAHA.117.09113. Epub 2017 May 30. PubMed PMID: 28559397; PubMed Central PMCID: PMC5507815.

Boeldt DS, Bird IM. Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia. J Endocrinol. 2017 Jan;232(1):R27-R44. Epub 2016 Oct 11. Review. PubMed PMID: 27729465; PubMed Central PMCID: PMC5115955.

Anaya HA, Yi FX, Boeldt DS, Krupp J, Grummer MA, Shah DM, Bird IM. Changes in Ca2+ Signaling and Nitric Oxide Output by Human Umbilical Vein Endothelium in Diabetic and Gestational Diabetic Pregnancies. Biol Reprod. 2015 Sep;93(3):60. doi: 10.1095/biolreprod.115.128645. Epub 2015 Jul 22. PubMed PMID: 26203178; PubMed Central PMCID: PMC4710185.

Boeldt DS, Grummer MA, Yi F, Magness RR, Bird IM. Phosphorylation of Ser-279/282 and Tyr-265 positions on Cx43 as possible mediators of VEGF-165 inhibition of pregnancy-adapted Ca2+ burst function in ovine uterine artery endothelial cells. Mol Cell Endocrinol. 2015 Sep 5;412:73-84. doi: 10.1016/j.mce.2015.05.030. Epub 2015 May 29. PubMed PMID: 26033246; PubMed Central PMCID: PMC4516676.

Boeldt DS, Grummer MA, Magness RR, Bird IM. Altered VEGF-stimulated Ca2+ signaling in part underlies pregnancy-adapted eNOS activity in UAEC. J Endocrinol. 2014 Oct;223(1):1-11. doi: 10.1530/JOE-14-0252. Epub 2014 Jul 25. PubMed PMID: 25063757; PubMed Central PMCID: PMC4161637.

Boeldt DS, Hankes AC, Alvarez RE, Khurshid N, Balistreri M, Grummer MA, Yi F, Bird IM. Pregnancy programming and preeclampsia: identifying a human endothelial model to study pregnancy-adapted endothelial function and endothelial adaptive failure in preeclamptic subjects. Adv Exp Med Biol. 2014;814:27-47. doi: 10.1007/978-1-4939-1031-1_4. Review. PubMed PMID: 25015799.

Morschauser TJ, Ramadoss J, Koch JM, Yi FX, Lopez GE, Bird IM, Magness RR. Local effects of pregnancy on connexin proteins that mediate Ca2+-associated uterine endothelial NO synthesis. Hypertension. 2014 Mar;63(3):589-94. doi: 10.1161/HYPERTENSIONAHA.113.01171. Epub 2013 Dec 23. PubMed PMID: 24366080; PubMed Central PMCID: PMC3945210.

Bird IM, Boeldt DS, Krupp J, Grummer MA, Yi FX, Magness RR. Pregnancy, programming and preeclampsia: gap junctions at the nexus of pregnancy-induced adaptation of endothelial function and endothelial adaptive failure in PE. Curr Vasc Pharmacol. 2013 Sep;11(5):712-29. Review. PubMed PMID: 24063383.