Placental Angiogenic Factors& Endothelial NO Production

04/01/2000 - 03/31/2006

Sponsor: NIH P01 HD38843 (Bird Project 1 PI, Core 2 PI)

Status: Completed

These studies provided a significant advance in both the understanding of normal control and coordination of Uterine artery and Placental artery endothelial function and the mechanism underlying pregnancy-induction of increased Uterine artery refractoriness to a variety of vasoconstrictors. As such they provided a new model of endothelial cell function on which future studies searching for the maternal and feto-placental vascular dysfunction leading to preeclampsia and IUGR were based.