Joanne K Rash, Lori A Seaborne, Megan Peterson, David M Kushner, Janelle N Sobecki
CONCLUSION: Women with cancer report integrative sexual health care to address sexual problems that are helpful and result in long-term improvement. Patients are overall highly adherent to recommended therapies, and nearly all would recommend the program to others.
Published: 02/16/2023
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer pmid:36795172
Matthew K Wagar, Ran Catherine Zhang, Paul Weisman, Ryan J Spencer, David M Kushner
CONCLUSION: We report a technique for the injection of fluorescein sodium for the visualization of vulvar Paget disease capable of providing accurate surgical margins and identification of occult satellite lesions with a high degree of safety and a favorable cost profile. This staged approach to vulvectomy could offer improved accuracy of resection for vulvar Paget disease with few drawbacks.
Published: 02/03/2023
Obstetrics and gynecology pmid:36735397
Jacqueline A Murtha, Natalie Liu, Jen Birstler, Bret M Hanlon, Manasa Venkatesh, Lawrence P Hanrahan, Tudor Borza, David M Kushner, Luke M Funk
CONCLUSIONS: BMI cut-points that accurately predicted development kidney and uterine cancer occurred in the overweight category. Analysis of multi-institutional EHR data may help determine if these relationships are generalizable to other health care settings. If they are, incorporation of BMI into the screening algorithms for these cancers may be warranted.
Published: 07/11/2022
International journal of obesity (2005) pmid:35817851
Connor C Wang, Matthew K Wagar, Amy Godecker, Ahmed Al-Niaimi, David M Kushner
CONCLUSIONS: Approximately one-third of patients will experience at least one G ≥ 3 complications after AD. Complications may be anticipated by low preoperative albumin. Patients can be counseled that, after AD, proceeding to subsequent NACT and ICS and achieving optimal debulking is common.
Published: 04/28/2022
Gynecologic oncology reports pmid:35478695
Yang Hu, Ahmed N Al-Niaimi, Alain Cagaanan, Elizabeth A Sadowski, David M Kushner, Paul S Weisman, Stephanie M McGregor
CONCLUSIONS: Large mass lesions following progestin therapy may histologically consist of DS with little to no residual neoplastic disease, such that perceived tumor size does not necessarily reflect extensive residual disease, especially in pre-menopausal patients. Intraoperative gross assessment alone may lead to unnecessary lymphadenectomy and/or oophorectomy, but this can potentially be prevented by using frozen section.
Published: 04/05/2021
Gynecologic oncology reports pmid:33816740
Lori A Seaborne, Megan Peterson, David M Kushner, Janelle Sobecki, Joanne K Rash
CONCLUSION: The WISH program enhances comprehensive survivorship care of female cancer survivors. Women report they benefit from care for sexual issues after cancer treatments. Advanced practitioners working in oncology are uniquely positioned to educate themselves, take leadership roles in the development and implementation of programs, and provide care to women affected by sexual side effects after cancer.
Published: 02/08/2021
Journal of the advanced practitioner in oncology pmid:33552660
Erica V Carballo, Kaley M Gyorfi, Aleksandar K Stanic, Paul Weisman, Christopher G Flynn, David M Kushner
CONCLUSION: This case demonstrates that inhibin B lacks specificity as a tumor marker for adult granulosa cell tumor, even at very high levels. Knowledge of benign alternative explanations for this finding can facilitate improved preoperative patient counseling. Pertinent literature is reviewed, with an emphasis on proposed hypotheses for inhibin overproduction.
Published: 11/18/2020
Gynecologic oncology reports pmid:33204793
Rowan Karaman, Jin Xu, Ross F Harrison, David M Kushner, Paul S Weisman, Yoram Shenker
CONCLUSION: Renin-secreting ovarian adult granulosa cell tumors are rare causes of hyperreninemia leading to hypertension and hypokalemia.
Published: 01/23/2020
AACE clinical case reports pmid:31967026
Paul S Weisman, Morgan Altinok, Erica V Carballo, David M Kushner, Jessica J F Kram, Marc Ladanyi, Sarah Chiang, Darya Buehler, Elizabeth L Dickson Michelson
No abstract
Published: 01/10/2020
The American journal of surgical pathology pmid:31917708
Taylor B Turner, David M Kushner, Abigail Ford Winkel, Gerald McGwin, Stephanie V Blank, Jeffery M Fowler, Kenneth H Kim, SGO Wellness Taskforce
CONCLUSIONS: A structured curriculum to promote wellness among gynecologic oncology fellows is feasible and was associated with observed decreased reported stress among fellows at participating programs. This curriculum addresses ACGME requirements regarding trainee well-being, and showed potential for more programmatic, nationwide implementation. Fellowship culture change was not directly measured, but may have been one of the most significant positive outcomes of the wellness program. Further...
Published: 01/09/2020
Gynecologic oncology pmid:31911007
Ross F Harrison, Jeremiah E Mcnamara, Claire B Beaumont, Elizabeth A Sadowski, Richard J Chappell, Mian M Shahzad, Ryan J Spencer, Ahmed N Al-Niaimi, Lisa M Barroilhet, Stephen L Rose, David M Kushner
CONCLUSIONS: Simple linear measurements of visceral fat obtained from preoperative imaging are more predictive than body mass index alone in anticipating surgeon-reported operative difficulty. These easily obtained measurements may assist in preoperative decision making in this challenging patient population.
Published: 01/15/2019
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:30640690
Emily R Rosen, David M Kushner, Aparna M Mahajan, Cara R King
CONCLUSIONS: A somatic missense mutation in the FOXL2 gene is a sensitive molecular marker for AGCT. Mutation analysis can help distinguish malignant from benign pathology to provide appropriate treatment and disease surveillance.
Published: 12/12/2018
Gynecologic oncology reports pmid:30533478
Ross F Harrison, Erin E Medlin, Chase B Petersen, Stephen L Rose, Ellen M Hartenbach, David M Kushner, Ryan J Spencer, Laurel W Rice, Ahmed N Al-Niaimi
CONCLUSION: The prevalence of obstructive sleep apnea or screening at risk for the condition is high among women presenting for surgery with a gynecologic oncologist. Providers should consider evaluating a patient's risk for obstructive sleep apnea in the preoperative setting, especially when risk factors for the condition are present.
Published: 05/25/2018
American journal of obstetrics and gynecology pmid:29792853
Brittany F Lees, Taylor P Stewart, Joanne K Rash, Shirley R Baron, Stacy Tessler Lindau, David M Kushner
More than 30% of women have a history of abuse. Women with cancer may be at substantially increased risk for abuse, but this issue is rarely discussed in the course of oncology care. Women with a history of abuse who present for cancer care commonly have a high prevalence of co-morbid illness. Sexual dysfunction, a highly prevalent but under-recognized condition among women of all ages, is also more common among both women with a history of abuse and women with cancer. Although common after...
Published: 04/18/2018
Gynecologic oncology pmid:29661496
Jeanne Carter, Christina Lacchetti, Barbara L Andersen, Debra L Barton, Sage Bolte, Shari Damast, Michael A Diefenbach, Katherine DuHamel, Judith Florendo, Patricia A Ganz, Shari Goldfarb, Sigrun Hallmeyer, David M Kushner, Julia H Rowland
Purpose The adaptation of the Cancer Care Ontario (CCO) guideline Interventions to Address Sexual Problems in People With Cancer provides recommendations to manage sexual function adverse effects that occur as a result of cancer diagnosis and/or treatment. Methods ASCO staff reviewed the guideline for developmental rigor and updated the literature search. An ASCO Expert Panel ( Table A1 ) was assembled to review the guideline content and recommendations. Results The ASCO Expert Panel determined...
Published: 12/12/2017
Journal of clinical oncology : official journal of the American Society of Clinical Oncology pmid:29227723
Erin A Bishop, James J Java, Kathleen N Moore, Nick M Spirtos, Michael L Pearl, Oliver Zivanovic, David M Kushner, Floor Backes, Chad A Hamilton, Melissa A Geller, Jean Hurteau, Cara Mathews, Robert M Wenham, Pedro T Ramirez, Susan Zweizig, Joan L Walker
CONCLUSION: Laparoscopic staging for uterine cancer is associated with decreased morbidity in the immediate postoperative period in patients ≥60 years old. These results allow for more accurate preoperative counseling. A minimally invasive approach to uterine cancer staging may decrease morbidity that could affect long-term survival.
Published: 10/18/2017
American journal of obstetrics and gynecology pmid:29037481
Carolyn K McCourt, Wei Deng, Don S Dizon, Heather A Lankes, Michael J Birrer, Michele M Lomme, Matthew A Powell, James E Kendrick, Joel N Saltzman, David Warshal, Meaghan E Tenney, David M Kushner, Carol Aghajanian
CONCLUSION: In this cohort of women, single agent ixabepilone showed modest but insufficient clinical activity.
Published: 12/29/2016
Gynecologic oncology pmid:28029447
Ilana Cass, Linda R Duska, Stephanie V Blank, Georgina Cheng, Nefertiti C duPont, Peter J Frederick, Emily K Hill, Carolyn M Matthews, Tarah L Pua, Kellie S Rath, Rachel Ruskin, Premal H Thaker, Andrew Berchuck, Bobbie S Gostout, David M Kushner, Jeff M Fowler
No abstract
Published: 08/31/2016
Gynecologic oncology pmid:27575910
Stacy Tessler Lindau, Emily M Abramsohn, Shirley R Baron, Judith Florendo, Hope K Haefner, Anuja Jhingran, Vanessa Kennedy, Mukta K Krane, David M Kushner, Jennifer McComb, Diane F Merritt, Julie E Park, Amy Siston, Margaret Straub, Lauren Streicher
Answer questions and earn CME/CNE Sexual concerns are prevalent in women with cancer or cancer history and are a factor in patient decision making about cancer treatment and risk-reduction options. Physical examination of the female cancer patient with sexual concerns, regardless of the type or site of her cancer, is an essential and early component of a comprehensive evaluation and effective treatment plan. Specialized practices are emerging that focus specifically on evaluation and treatment...
Published: 01/20/2016
CA: a cancer journal for clinicians pmid:26784536
Erin E Medlin, David M Kushner, Lisa Barroilhet
The management of early stage cervical cancer often includes surgery in the form of radical hysterectomy, radical trachelectomy, or radical parametrectomy. Surgical techniques have evolved to include minimal invasive approaches, and more recently, to include robotic assisted techniques. This review highlights the evolution of surgical management of early cervical cancer and specifically explores robotic assisted radical hysterectomy, radical trachelectomy, radical parametrectomy, and the role of...
Published: 01/16/2016
Journal of surgical oncology pmid:26768315
Laura B Huffman, Ellen M Hartenbach, Jeanne Carter, Joanne K Rash, David M Kushner
CONCLUSION: Oncology providers can make a significant impact on the QoL of gynecologic cancer survivors by addressing sexual health concerns. Simple strategies can be implemented into clinical practice to discuss and treat many sexual issues. Referral to specialized sexual health providers may be needed to address more complex problems.
Published: 11/12/2015
Gynecologic oncology pmid:26556768
Elizabeth A Sadowski, Jessica B Robbins, Kristie Guite, Krupa Patel-Lippmann, Alejandro Munoz del Rio, David M Kushner, Ahmed Al-Niaimi
CONCLUSION: Preoperative MRI and CA-125 evaluation identified women for lymphadenectomy with a high NPV.
Published: 10/27/2015
AJR. American journal of roentgenology pmid:26496578
Sana M Salih, Samet Albayrak, Songwon Seo, Sarah L Stewart, Kristen Bradley, David M Kushner
CONCLUSION: OT preserves menstrual cycle regularity without negatively impacting patients' quality of life. The utility of OT as an effective fertility preservation option is hampered by the low utilization rate of in vitro fertilization and lack of ovarian reserve assessment following OT.
Published: 09/19/2015
The Journal of reproductive medicine pmid:26380495
Lori A Seaborne, Ronald J Prince, David M Kushner
CONCLUSIONS: PA programs in the United States appear to compare favorably with the training offered to medical students in regard to time spent on sexual health education. Transgender issues were least well-covered of all the topics queried.
Published: 04/10/2015
The journal of sexual medicine pmid:25856226
Qiaoying Jiang, Liwei Yang, Charles Ashley, Erin E Medlin, David M Kushner, Yanmei Zheng
CONCLUSION: This case highlights the difficulties in diagnosis of abnormal placentation and an unusual presentation of uterine rupture. This case was managed successfully laparoscopically.
Published: 01/23/2015
BMC women's health pmid:25608736
Ahmed N Al-Niaimi, Mostafa Ahmed, Nikki Burish, Saygin A Chackmakchy, Songwon Seo, Stephen Rose, Ellen Hartenbach, David M Kushner, Nasia Safdar, Laurel Rice, Joseph Connor
CONCLUSIONS: Initiating intensive glycemic control for 24h after gynecologic oncology surgery in patients with DM and postoperative hyperglycemia lowers the SSI rate by 35% (OR = 0.5) compared to patients receiving intermittent sliding scale insulin and to a rate equivalent to non-diabetics.
Published: 09/30/2014
Gynecologic oncology pmid:25263249
Latoya J Perry, Onur Guralp, Ahmed Al-Niaimi, Noah A Zucker, David M Kushner
► PET-CT scan was positive for metastasis of vulvar cancer to lymph nodes however they were histologically negative. ► Frozen section analysis should be performed at the time of surgery to confirm status of suspicious lymph nodes.
Published: 12/28/2013
Gynecologic oncology case reports pmid:24371671
Alison M Gold, Noah A Zucker, Mian M K Shahzad, David M Kushner
No abstract
Published: 12/28/2013
Gynecologic oncology case reports pmid:24371658
Shitanshu Uppal, Ahmed Al-Niaimi, Laurel W Rice, Stephen L Rose, David M Kushner, Ryan J Spencer, Ellen Hartenbach
CONCLUSION: Preoperative albumin levels <3g/dL identify a population of patients at a very high-risk of experiencing perioperative morbidity and 30-day mortality after open surgery.
Published: 08/22/2013
Gynecologic oncology pmid:23962700
Onur Guralp, Susan M Sheridan, Josephine Harter, James Louis Hinshaw, Songwon Seo, Ellen M Hartenbach, Steven Lindheim, Sarah Stewart, David M Kushner
CONCLUSIONS: Most patients with early endometrial cancer can undergo SIS procedures with adequate cytology specimens obtained from distention media. However, the sensitivity is low, and refinements are necessary before utilizing as a diagnostic test. In cases with positive results, the patient may be able to avoid other costly and painful procedures.
Published: 07/25/2013
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:23881100
Yang Liu, Rebecca J Whelan, Bikash R Pattnaik, Kai Ludwig, Enkateswar Subudhi, Helen Rowland, Nick Claussen, Noah Zucker, Shitanshu Uppal, David M Kushner, Mildred Felder, Manish S Patankar, Arvinder Kapur
Novel strategies are necessary to improve chemotherapy response in advanced and recurrent endometrial cancer. Here, we demonstrate that terpenoids present in the Steam Distilled Extract of Ginger (SDGE) are potent inhibitors of proliferation of endometrial cancer cells. SDGE, isolated from six different batches of ginger rhizomes, consistently inhibited proliferation of the endometrial cancer cell lines Ishikawa and ECC-1 at IC(50) of 1.25 µg/ml. SDGE also enhanced the anti-proliferative effect...
Published: 01/10/2013
PloS one pmid:23300887
Jennifer E Lin, Songwon Seo, David M Kushner, Stephen L Rose
CONCLUSION: When a grossly normal appendix is removed during surgery for a mucinous ovarian neoplasm without evidence of pseudomyxoma peritonei, no primary or metastatic mucinous appendiceal tumors are found.
Published: 11/03/2012
American journal of obstetrics and gynecology pmid:23117124
Nonyem Onujiogu, Tasha Johnson, Songwon Seo, Katherine Mijal, Joanne Rash, Lori Seaborne, Stephen Rose, David M Kushner
CONCLUSION: This patient population commonly thought to be at low risk actually suffers from severe sexual dysfunction. The four risk factors revealed by multivariate analysis need to be studied in greater detail in order to appropriately target patients and develop meaningful interventions.
Published: 08/23/2011
Gynecologic oncology pmid:21855974
Onur Guralp, David M Kushner
CONCLUSION: PPW rates vary between 0-14% after dilatation and curettage (D&C), 0-83% after H/S, 0-10% after L/S and 12-52% after SIS. The majority of the studies about EC cell dissemination during H/S and SIS suggest that they increase the risk of spill. There is not enough evidence to support the association between tumor spill and pressure, type and volume of distension medium, duration of the procedure, stage, grade and interval between H/S or SIS and laparotomy. Investigation into the rate...
Published: 08/13/2011
Archives of gynecology and obstetrics pmid:21837428
Ahmed N Al-Niaimi, Margaret H Einstein, LaToya Perry, Ellen M Hartenbach, David M Kushner
CONCLUSION: Technically, the surgery is feasible and could be performed by any gynecologic oncologist who is skilled in radical pelvic surgery and the robotic system. The long-term obstetric and oncologic outcome of this technique would be expected to match the outcome of the other radical trachelectomy techniques in the published literature, but is yet to be fully elucidated.
Published: 10/16/2010
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics pmid:20947081
David B Engle, Jennifer A Belisle, Jennifer A A Gubbels, Sarah E Petrie, Paul R Hutson, David M Kushner, Manish S Patankar
CONCLUSION: ALCAR does not affect the cytotoxicity of paclitaxel or carboplatin. There was no increase in proliferation, or NGFR of OVCAR-3 or SKOV-3 cells exposed to ALCAR.
Published: 03/06/2009
Gynecologic oncology pmid:19263582
M Heather Einstein, David M Kushner, Joseph P Connor, Alex A Bohl, Thomas J Best, Michael D Evans, Richard J Chappell, Ellen M Hartenbach
CONCLUSION: A protocol of dual prophylaxis with prolonged prophylaxis in high-risk patients was successfully implemented and was associated with a significant reduction in the rate of venous thromboembolism without increasing bleeding complications.
Published: 11/04/2008
Obstetrics and gynecology pmid:18978110
David B Engle, Kristin A Bradley, Rick J Chappell, Joseph P Conner, Ellen M Hartenbach, David M Kushner
CONCLUSION: The LAIB procedure appears safe, but substantially increases operating department time. No significant decrease in late high-grade toxicities were detected in comparison with TrIB. The LAIB procedure allows for both lysis of adhesions and identification of unknown carcinomatosis.
Published: 07/29/2008
Journal of minimally invasive gynecology pmid:18657479
Emily Berry, Steven R Lindheim, Joseph P Connor, Ellen M Hartenbach, Julian C Schink, Josephine Harter, Jens C Eickhoff, David M Kushner
CONCLUSION: Transtubal spill occurs during sonohysterography. No critical spill volume was identified. A highly diagnostic tool when abnormal bleeding is evaluated, sonohysterography has a low probability of cancer cell dissemination.
Published: 05/06/2008
American journal of obstetrics and gynecology pmid:18456240
David M Kushner, Joseph P Connor, Michael A Wilson, G Reza Hafez, Richard J Chappell, Sarah L Stewart, Ellen M Hartenbach
CONCLUSIONS: Laparoscopic SLN mapping can be newly introduced into gynecologic oncology centers with high detection rates and negative predictive values. The visualization of blue dye in SLNs is transient, and this negative time correlation may explain the previously reported inferior detection rates with this technique. CLINICAL TRIAL REGISTRATION.: ClinicalTrials.gov, http://www.clinicaltrials.gov, NCT 00205010.
Published: 06/15/2007
Gynecologic oncology pmid:17560635
David M Kushner, Joseph P Connor, Federico Sanchez, Michael Volk, Julian C Schink, Howard H Bailey, Linda S Harris, Sarah L Stewart, Jason Fine, Ellen M Hartenbach, Wisconsin Oncology Network
CONCLUSION: The weekly regimen of carboplatin and docetaxel has a good response rate with an acceptable toxicity profile.
Published: 01/30/2007
Gynecologic oncology pmid:17258800
Jayashree M Paranjape, Da Xu, David M Kushner, James Okicki, Daniel J Lindner, Hagen Cramer, Robert H Silverman, Douglas W Leaman
Ribonuclease L (RNase L) is a latent single-stranded RNA-directed endoribonuclease that is activated on binding to short 2'-5'-linked oligoadenylates (2-5A), a feature that has led to its use in antisense therapeutic strategies. By attaching a 2-5A moiety to the 5' terminus of standard antisense oligonucleotides, it is possible to activate RNase L and guide it to specific RNAs for degradation. These 2-5A antisense chimeras have been used successfully to target a variety of cellular and viral...
Published: 09/19/2006
Oligonucleotides pmid:16978086
James K Robinson, David M Kushner
CONCLUSION: Home-based practice on a mirrored laparoscopy trainer improves hand-eye coordination in inexperienced surgeons and results in more frequent practice.
Published: 03/11/2006
Journal of minimally invasive gynecology pmid:16527711
David M Kushner, Regina LaGalbo, Joseph P Connor, Rick Chappell, Sarah L Stewart, Ellen M Hartenbach
CONCLUSION: The results suggest that although the continuous infusion system seems safe, it is not efficacious in this patient population.
Published: 08/02/2005
Obstetrics and gynecology pmid:16055569
Steven R Lindheim, Natalie Adsuar, David M Kushner, Elizabeth A Pritts, David L Olive
A number of medical conditions, including abnormal uterine bleeding, endometrial cancer, monitoring tamoxifen therapy, infertility, and recurrent abortion, warrant investigation of the female genital tract. Diagnostic studies including hysterosalpingogram, ultrasound, and sonohysterography have proved useful in the investigation of these gynecologic conditions. This article discusses each of these tests with particular emphasis on sonohysterography and their current and potential contributions...
Published: 10/29/2003
Obstetrical & gynecological survey pmid:14581828