Portrait of David M. Kushner
David M. Kushner, MD, FACOG
Professor, Vice Chair of Faculty Development, Education and Wellness, Co-Chair of Faculty Development, John and Jeanne Flesch Professor in Gynecologic Oncology
Gynecologic Oncology

Office Address

UW Hospital and Clinics
H4/648
600 Highland Ave
Madison, WI, 53792

Clinic Address

Gynecology Oncology Clinic
600 Highland Ave
Madison, WI, 53705
Phone: 608-265-1700

Administrative Assistant

Dr. David Kushner is Vice Chair of Faculty Development, Education & Wellness and the tenured Flesch Professor of Gynecologic Oncology in the University of Wisconsin School of Medicine and Public Health Department of Obstetrics and Gynecology. Prior to this current role, he was Vice Chair of Clinical Research (2016-2022), building infrastructure across the Department to support and grow clinical trials. From 2006-2017, he directed the Gynecologic Oncology program at the UW Carbone Cancer Center (UWCCC). 

Dr. Kushner is an expert in the surgical and chemotherapeutic management of patients with gynecologic cancer. His research interest focuses on minimizing the negative impact of cancer and subsequent treatments on patients’ quality of life: sexual health after cancer, fertility/menopause-sparing surgery, postoperative pain management. To this end, he has been a U.S. pioneer for multiple innovative minimally invasive and fertility-sparing surgeries. He also helped found the Scientific Network on Female Sexual Health and Cancer, an international consortium of leading researchers dedicated to the scientific pursuit of improving sexual health for women after a cancer diagnosis. Dr. Kushner served as the International Chair of this network from 2014-2016. 

Dr. Kushner has worked to position UW as one of the nation’s premier institutions studying quality of life in gynecologic cancer. The UW environment offers outstanding collaborators such as the Center for Healthy Minds and the UW Health Women’s Integrative Sexual Health (WISH) clinic. Dr. Kushner was the founding Medical Director of the WISH clinic and helps oversee its research efforts. This program, along with the ongoing research in patient-reported outcomes, humor, and wellness, is positioning his group to apply for larger funding sources to study quality of life in gynecologic cancer. He is the primary investigator on multiple studies evaluating sexual health among gynecologic cancer survivors. Dr. Kushner has also acted as the Principal Investigator (PI) for NRG (formerly Gynecologic Oncology) at University of Wisconsin and Co-PI on the UWCCC institutional NIH Lead Academic Performance Site (LAPS) U10 grant. 

His interest in wellness runs beyond patients to the caregivers as well. He helped found and chaired the Society of Gynecology Oncology (SGO) Physician Wellness Taskforce. Locally, he founded and chaired the UW Department of Ob-Gyn Wellness Committee and acted as departmental representative for the UW Health Wellness Taskforce. He has researched and written seminal articles on burnout and wellness among cancer providers. 

Dr. Kushner was elected to the SGO Board of Directors. He also chairs the SGO’s State of the Society Survey, conducted every five years to provide detailed demographic and practice data that members can utilize to inform and support their clinical practices. He is an American Board of Obstetrics & Gynecology examiner for the oral gynecologic oncology board exam and has Chaired the American College of Obstetricians and Gynecologists (ACOG) PROLOG Taskforce for Gynecologic Oncology & Critical Care.

B.S. University of Michigan, Ann Arbor, MI
M.D. Wayne State University School of Medicine, Detroit, MI
Residency Northwestern University Medical School/ Prentice Women's Hospital, Chicago, IL
Fellowship The Cleveland Clinic Foundation, Cleveland, OH

American College of Obstetricians and Gynecologists 

Gynecologic Oncology

Vice Chair, Faculty Development, Education and Wellness

UW Health 2019 Clinical Educator Award 

Society of Gynecologic Oncology: State of the Subspecialty Survey, Co-Chair 

SSM Health/St Mary’s Foundation: Physician Guardian Angel Award 

PROLOG: Gynecologic Oncology & Critical Care, Task Force Co-Chair and Member 

Society of Gynecologic Oncology: Elected to the Board of Directors 

Mentor Training for Clinical and Translational Researchers,
UW Institute for Clinical and Translational Research 

The Ellen M. Hartenbach Award,
University of Wisconsin Department of Obstetrics & Gynecology 

Editorial Board – Gynecologic Oncology Case Reviews 

Society of Gynecologic Oncology: Wellness Taskforce, Founding Member and Co-Chair 

Leadership Development for Physicians in Academic Health Centers,
Harvard T.H. Chan School of Public Health

American College of Obstetricians and Gynecologists, Fellow 

Society of Gynecologic Oncology 

American Association of Gynecologic Laparoscopists 

American Society of Clinical Oncology 

Northwestern Obstetrical and Gynecological Society 

American Gynecologic & Obstetrical Society


Patient reported improvement in sexual health outcomes following care in a sexual health clinic for women with cancer

Joanne K Rash, Lori A Seaborne, Megan Peterson, David M Kushner, Janelle N Sobecki

CONCLUSION: Women with cancer report integrative sexual health care to address sexual problems that are helpful and result in long-term improvement. Patients are overall highly adherent to recommended therapies, and nearly all would recommend the program to others.

Published: 02/16/2023

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer pmid:36795172

Fluorescein Mapping in Vulvar Paget Disease

Matthew K Wagar, Ran Catherine Zhang, Paul Weisman, Ryan J Spencer, David M Kushner

CONCLUSION: We report a technique for the injection of fluorescein sodium for the visualization of vulvar Paget disease capable of providing accurate surgical margins and identification of occult satellite lesions with a high degree of safety and a favorable cost profile. This staged approach to vulvectomy could offer improved accuracy of resection for vulvar Paget disease with few drawbacks.

Published: 02/03/2023

Obstetrics and gynecology pmid:36735397

Obesity and "obesity-related" cancers: are there body mass index cut-points?

Jacqueline A Murtha, Natalie Liu, Jen Birstler, Bret M Hanlon, Manasa Venkatesh, Lawrence P Hanrahan, Tudor Borza, David M Kushner, Luke M Funk

CONCLUSIONS: BMI cut-points that accurately predicted development kidney and uterine cancer occurred in the overweight category. Analysis of multi-institutional EHR data may help determine if these relationships are generalizable to other health care settings. If they are, incorporation of BMI into the screening algorithms for these cancers may be warranted.

Published: 07/11/2022

International journal of obesity (2005) pmid:35817851

When we open and close: Postoperative outcomes after aborted primary cytoreduction for ovarian cancer

Connor C Wang, Matthew K Wagar, Amy Godecker, Ahmed Al-Niaimi, David M Kushner

CONCLUSIONS: Approximately one-third of patients will experience at least one G ≥ 3 complications after AD. Complications may be anticipated by low preoperative albumin. Patients can be counseled that, after AD, proceeding to subsequent NACT and ICS and achieving optimal debulking is common.

Published: 04/28/2022

Gynecologic oncology reports pmid:35478695

Prominent decidualization following progestin treatment for endometrial hyperplasia and carcinoma as a mimic of large residual tumor: A cautionary tale

Yang Hu, Ahmed N Al-Niaimi, Alain Cagaanan, Elizabeth A Sadowski, David M Kushner, Paul S Weisman, Stephanie M McGregor

CONCLUSIONS: Large mass lesions following progestin therapy may histologically consist of DS with little to no residual neoplastic disease, such that perceived tumor size does not necessarily reflect extensive residual disease, especially in pre-menopausal patients. Intraoperative gross assessment alone may lead to unnecessary lymphadenectomy and/or oophorectomy, but this can potentially be prevented by using frozen section.

Published: 04/05/2021

Gynecologic oncology reports pmid:33816740

Development, Implementation, and Patient Perspectives of the Women's Integrative Sexual Health Program: A Program Designed to Address the Sexual Side Effects of Cancer Treatment

Lori A Seaborne, Megan Peterson, David M Kushner, Janelle Sobecki, Joanne K Rash

CONCLUSION: The WISH program enhances comprehensive survivorship care of female cancer survivors. Women report they benefit from care for sexual issues after cancer treatments. Advanced practitioners working in oncology are uniquely positioned to educate themselves, take leadership roles in the development and implementation of programs, and provide care to women affected by sexual side effects after cancer.

Published: 02/08/2021

Journal of the advanced practitioner in oncology pmid:33552660

Benign ovarian thecoma with markedly elevated serum inhibin B levels mimicking adult granulosa cell tumor

Erica V Carballo, Kaley M Gyorfi, Aleksandar K Stanic, Paul Weisman, Christopher G Flynn, David M Kushner

CONCLUSION: This case demonstrates that inhibin B lacks specificity as a tumor marker for adult granulosa cell tumor, even at very high levels. Knowledge of benign alternative explanations for this finding can facilitate improved preoperative patient counseling. Pertinent literature is reviewed, with an emphasis on proposed hypotheses for inhibin overproduction.

Published: 11/18/2020

Gynecologic oncology reports pmid:33204793

RENIN-SECRETING OVARIAN ADULT GRANULOSA CELL TUMOR IN A PATIENT WITH NEW-ONSET HYPERTENSION AND HYPOKALEMIA

Rowan Karaman, Jin Xu, Ross F Harrison, David M Kushner, Paul S Weisman, Yoram Shenker

CONCLUSION: Renin-secreting ovarian adult granulosa cell tumors are rare causes of hyperreninemia leading to hypertension and hypokalemia.

Published: 01/23/2020

AACE clinical case reports pmid:31967026

Uterine Cervical Sarcoma With a Novel RET-SPECC1L Fusion in an Adult: A Case Which Expands the Homology Between RET-rearranged and NTRK-rearranged Tumors

Paul S Weisman, Morgan Altinok, Erica V Carballo, David M Kushner, Jessica J F Kram, Marc Ladanyi, Sarah Chiang, Darya Buehler, Elizabeth L Dickson Michelson

No abstract

Published: 01/10/2020

The American journal of surgical pathology pmid:31917708

The Society of Gynecologic Oncology wellness curriculum pilot: A groundbreaking initiative for fellowship training

Taylor B Turner, David M Kushner, Abigail Ford Winkel, Gerald McGwin, Stephanie V Blank, Jeffery M Fowler, Kenneth H Kim, SGO Wellness Taskforce

CONCLUSIONS: A structured curriculum to promote wellness among gynecologic oncology fellows is feasible and was associated with observed decreased reported stress among fellows at participating programs. This curriculum addresses ACGME requirements regarding trainee well-being, and showed potential for more programmatic, nationwide implementation. Fellowship culture change was not directly measured, but may have been one of the most significant positive outcomes of the wellness program. Further...

Published: 01/09/2020

Gynecologic oncology pmid:31911007

Using simple radiologic measurements to anticipate surgical challenge in endometrial cancer: a prospective study

Ross F Harrison, Jeremiah E Mcnamara, Claire B Beaumont, Elizabeth A Sadowski, Richard J Chappell, Mian M Shahzad, Ryan J Spencer, Ahmed N Al-Niaimi, Lisa M Barroilhet, Stephen L Rose, David M Kushner

CONCLUSIONS: Simple linear measurements of visceral fat obtained from preoperative imaging are more predictive than body mass index alone in anticipating surgeon-reported operative difficulty. These easily obtained measurements may assist in preoperative decision making in this challenging patient population.

Published: 01/15/2019

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:30640690

Cancer overturned: Endometrioma mimicking granulosa cell tumor and the importance of FOXL2 analysis

Emily R Rosen, David M Kushner, Aparna M Mahajan, Cara R King

CONCLUSIONS: A somatic missense mutation in the FOXL2 gene is a sensitive molecular marker for AGCT. Mutation analysis can help distinguish malignant from benign pathology to provide appropriate treatment and disease surveillance.

Published: 12/12/2018

Gynecologic oncology reports pmid:30533478

Preoperative obstructive sleep apnea screening in gynecologic oncology patients

Ross F Harrison, Erin E Medlin, Chase B Petersen, Stephen L Rose, Ellen M Hartenbach, David M Kushner, Ryan J Spencer, Laurel W Rice, Ahmed N Al-Niaimi

CONCLUSION: The prevalence of obstructive sleep apnea or screening at risk for the condition is high among women presenting for surgery with a gynecologic oncologist. Providers should consider evaluating a patient's risk for obstructive sleep apnea in the preoperative setting, especially when risk factors for the condition are present.

Published: 05/25/2018

American journal of obstetrics and gynecology pmid:29792853

Abuse, cancer and sexual dysfunction in women: A potentially vicious cycle

Brittany F Lees, Taylor P Stewart, Joanne K Rash, Shirley R Baron, Stacy Tessler Lindau, David M Kushner

More than 30% of women have a history of abuse. Women with cancer may be at substantially increased risk for abuse, but this issue is rarely discussed in the course of oncology care. Women with a history of abuse who present for cancer care commonly have a high prevalence of co-morbid illness. Sexual dysfunction, a highly prevalent but under-recognized condition among women of all ages, is also more common among both women with a history of abuse and women with cancer. Although common after...

Published: 04/18/2018

Gynecologic oncology pmid:29661496

Interventions to Address Sexual Problems in People With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Adaptation of Cancer Care Ontario Guideline

Jeanne Carter, Christina Lacchetti, Barbara L Andersen, Debra L Barton, Sage Bolte, Shari Damast, Michael A Diefenbach, Katherine DuHamel, Judith Florendo, Patricia A Ganz, Shari Goldfarb, Sigrun Hallmeyer, David M Kushner, Julia H Rowland

Purpose The adaptation of the Cancer Care Ontario (CCO) guideline Interventions to Address Sexual Problems in People With Cancer provides recommendations to manage sexual function adverse effects that occur as a result of cancer diagnosis and/or treatment. Methods ASCO staff reviewed the guideline for developmental rigor and updated the literature search. An ASCO Expert Panel ( Table A1 ) was assembled to review the guideline content and recommendations. Results The ASCO Expert Panel determined...

Published: 12/12/2017

Journal of clinical oncology : official journal of the American Society of Clinical Oncology pmid:29227723

Surgical outcomes among elderly women with endometrial cancer treated by laparoscopic hysterectomy: a NRG/Gynecologic Oncology Group study

Erin A Bishop, James J Java, Kathleen N Moore, Nick M Spirtos, Michael L Pearl, Oliver Zivanovic, David M Kushner, Floor Backes, Chad A Hamilton, Melissa A Geller, Jean Hurteau, Cara Mathews, Robert M Wenham, Pedro T Ramirez, Susan Zweizig, Joan L Walker

CONCLUSION: Laparoscopic staging for uterine cancer is associated with decreased morbidity in the immediate postoperative period in patients ≥60 years old. These results allow for more accurate preoperative counseling. A minimally invasive approach to uterine cancer staging may decrease morbidity that could affect long-term survival.

Published: 10/18/2017

American journal of obstetrics and gynecology pmid:29037481

A phase II evaluation of ixabepilone in the treatment of recurrent/persistent carcinosarcoma of the uterus, an NRG Oncology/Gynecologic Oncology Group study

Carolyn K McCourt, Wei Deng, Don S Dizon, Heather A Lankes, Michael J Birrer, Michele M Lomme, Matthew A Powell, James E Kendrick, Joel N Saltzman, David Warshal, Meaghan E Tenney, David M Kushner, Carol Aghajanian

CONCLUSION: In this cohort of women, single agent ixabepilone showed modest but insufficient clinical activity.

Published: 12/29/2016

Gynecologic oncology pmid:28029447

Stress and burnout among gynecologic oncologists: A Society of Gynecologic Oncology Evidence-based Review and Recommendations

Ilana Cass, Linda R Duska, Stephanie V Blank, Georgina Cheng, Nefertiti C duPont, Peter J Frederick, Emily K Hill, Carolyn M Matthews, Tarah L Pua, Kellie S Rath, Rachel Ruskin, Premal H Thaker, Andrew Berchuck, Bobbie S Gostout, David M Kushner, Jeff M Fowler

No abstract

Published: 08/31/2016

Gynecologic oncology pmid:27575910

Physical examination of the female cancer patient with sexual concerns: What oncologists and patients should expect from consultation with a specialist

Stacy Tessler Lindau, Emily M Abramsohn, Shirley R Baron, Judith Florendo, Hope K Haefner, Anuja Jhingran, Vanessa Kennedy, Mukta K Krane, David M Kushner, Jennifer McComb, Diane F Merritt, Julie E Park, Amy Siston, Margaret Straub, Lauren Streicher

Answer questions and earn CME/CNE Sexual concerns are prevalent in women with cancer or cancer history and are a factor in patient decision making about cancer treatment and risk-reduction options. Physical examination of the female cancer patient with sexual concerns, regardless of the type or site of her cancer, is an essential and early component of a comprehensive evaluation and effective treatment plan. Specialized practices are emerging that focus specifically on evaluation and treatment...

Published: 01/20/2016

CA: a cancer journal for clinicians pmid:26784536

Robotic surgery for early stage cervical cancer: Evolution and current trends

Erin E Medlin, David M Kushner, Lisa Barroilhet

The management of early stage cervical cancer often includes surgery in the form of radical hysterectomy, radical trachelectomy, or radical parametrectomy. Surgical techniques have evolved to include minimal invasive approaches, and more recently, to include robotic assisted techniques. This review highlights the evolution of surgical management of early cervical cancer and specifically explores robotic assisted radical hysterectomy, radical trachelectomy, radical parametrectomy, and the role of...

Published: 01/16/2016

Journal of surgical oncology pmid:26768315

Maintaining sexual health throughout gynecologic cancer survivorship: A comprehensive review and clinical guide

Laura B Huffman, Ellen M Hartenbach, Jeanne Carter, Joanne K Rash, David M Kushner

CONCLUSION: Oncology providers can make a significant impact on the QoL of gynecologic cancer survivors by addressing sexual health concerns. Simple strategies can be implemented into clinical practice to discuss and treat many sexual issues. Referral to specialized sexual health providers may be needed to address more complex problems.

Published: 11/12/2015

Gynecologic oncology pmid:26556768

Preoperative Pelvic MRI and Serum Cancer Antigen-125: Selecting Women With Grade 1 Endometrial Cancer for Lymphadenectomy

Elizabeth A Sadowski, Jessica B Robbins, Kristie Guite, Krupa Patel-Lippmann, Alejandro Munoz del Rio, David M Kushner, Ahmed Al-Niaimi

CONCLUSION: Preoperative MRI and CA-125 evaluation identified women for lymphadenectomy with a high NPV.

Published: 10/27/2015

AJR. American journal of roentgenology pmid:26496578

Diminished Utilization of in Vitro Fertilization Following Ovarian Transposition in Cervical Cancer Patients

Sana M Salih, Samet Albayrak, Songwon Seo, Sarah L Stewart, Kristen Bradley, David M Kushner

CONCLUSION: OT preserves menstrual cycle regularity without negatively impacting patients' quality of life. The utility of OT as an effective fertility preservation option is hampered by the low utilization rate of in vitro fertilization and lack of ovarian reserve assessment following OT.

Published: 09/19/2015

The Journal of reproductive medicine pmid:26380495

Sexual health education in U.S. physician assistant programs

Lori A Seaborne, Ronald J Prince, David M Kushner

CONCLUSIONS: PA programs in the United States appear to compare favorably with the training offered to medical students in regard to time spent on sexual health education. Transgender issues were least well-covered of all the topics queried.

Published: 04/10/2015

The journal of sexual medicine pmid:25856226

Uterine rupture disguised by urinary retention following a second trimester induced abortion: a case report

Qiaoying Jiang, Liwei Yang, Charles Ashley, Erin E Medlin, David M Kushner, Yanmei Zheng

CONCLUSION: This case highlights the difficulties in diagnosis of abnormal placentation and an unusual presentation of uterine rupture. This case was managed successfully laparoscopically.

Published: 01/23/2015

BMC women's health pmid:25608736

Intensive postoperative glucose control reduces the surgical site infection rates in gynecologic oncology patients

Ahmed N Al-Niaimi, Mostafa Ahmed, Nikki Burish, Saygin A Chackmakchy, Songwon Seo, Stephen Rose, Ellen Hartenbach, David M Kushner, Nasia Safdar, Laurel Rice, Joseph Connor

CONCLUSIONS: Initiating intensive glycemic control for 24h after gynecologic oncology surgery in patients with DM and postoperative hyperglycemia lowers the SSI rate by 35% (OR = 0.5) compared to patients receiving intermittent sliding scale insulin and to a rate equivalent to non-diabetics.

Published: 09/30/2014

Gynecologic oncology pmid:25263249

False positive PET-CT scan and clinical examination in a patient with locally advanced vulvar cancer

Latoya J Perry, Onur Guralp, Ahmed Al-Niaimi, Noah A Zucker, David M Kushner

► PET-CT scan was positive for metastasis of vulvar cancer to lymph nodes however they were histologically negative. ► Frozen section analysis should be performed at the time of surgery to confirm status of suspicious lymph nodes.

Published: 12/28/2013

Gynecologic oncology case reports pmid:24371671

Community screening leading to the diagnosis of androgen insensitivity syndrome at the age of 65

Alison M Gold, Noah A Zucker, Mian M K Shahzad, David M Kushner

No abstract

Published: 12/28/2013

Gynecologic oncology case reports pmid:24371658

Preoperative hypoalbuminemia is an independent predictor of poor perioperative outcomes in women undergoing open surgery for gynecologic malignancies

Shitanshu Uppal, Ahmed Al-Niaimi, Laurel W Rice, Stephen L Rose, David M Kushner, Ryan J Spencer, Ellen Hartenbach

CONCLUSION: Preoperative albumin levels <3g/dL identify a population of patients at a very high-risk of experiencing perioperative morbidity and 30-day mortality after open surgery.

Published: 08/22/2013

Gynecologic oncology pmid:23962700

A new diagnostic test for endometrial cancer?: Cytology analysis of sonohysterography distention media

Onur Guralp, Susan M Sheridan, Josephine Harter, James Louis Hinshaw, Songwon Seo, Ellen M Hartenbach, Steven Lindheim, Sarah Stewart, David M Kushner

CONCLUSIONS: Most patients with early endometrial cancer can undergo SIS procedures with adequate cytology specimens obtained from distention media. However, the sensitivity is low, and refinements are necessary before utilizing as a diagnostic test. In cases with positive results, the patient may be able to avoid other costly and painful procedures.

Published: 07/25/2013

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society pmid:23881100

Terpenoids from Zingiber officinale (Ginger) induce apoptosis in endometrial cancer cells through the activation of p53

Yang Liu, Rebecca J Whelan, Bikash R Pattnaik, Kai Ludwig, Enkateswar Subudhi, Helen Rowland, Nick Claussen, Noah Zucker, Shitanshu Uppal, David M Kushner, Mildred Felder, Manish S Patankar, Arvinder Kapur

Novel strategies are necessary to improve chemotherapy response in advanced and recurrent endometrial cancer. Here, we demonstrate that terpenoids present in the Steam Distilled Extract of Ginger (SDGE) are potent inhibitors of proliferation of endometrial cancer cells. SDGE, isolated from six different batches of ginger rhizomes, consistently inhibited proliferation of the endometrial cancer cell lines Ishikawa and ECC-1 at IC(50) of 1.25 µg/ml. SDGE also enhanced the anti-proliferative effect...

Published: 01/10/2013

PloS one pmid:23300887

The role of appendectomy for mucinous ovarian neoplasms

Jennifer E Lin, Songwon Seo, David M Kushner, Stephen L Rose

CONCLUSION: When a grossly normal appendix is removed during surgery for a mucinous ovarian neoplasm without evidence of pseudomyxoma peritonei, no primary or metastatic mucinous appendiceal tumors are found.

Published: 11/03/2012

American journal of obstetrics and gynecology pmid:23117124

Survivors of endometrial cancer: who is at risk for sexual dysfunction?

Nonyem Onujiogu, Tasha Johnson, Songwon Seo, Katherine Mijal, Joanne Rash, Lori Seaborne, Stephen Rose, David M Kushner

CONCLUSION: This patient population commonly thought to be at low risk actually suffers from severe sexual dysfunction. The four risk factors revealed by multivariate analysis need to be studied in greater detail in order to appropriately target patients and develop meaningful interventions.

Published: 08/23/2011

Gynecologic oncology pmid:21855974

Iatrogenic transtubal spill of endometrial cancer: risk or myth

Onur Guralp, David M Kushner

CONCLUSION: PPW rates vary between 0-14% after dilatation and curettage (D&C), 0-83% after H/S, 0-10% after L/S and 12-52% after SIS. The majority of the studies about EC cell dissemination during H/S and SIS suggest that they increase the risk of spill. There is not enough evidence to support the association between tumor spill and pressure, type and volume of distension medium, duration of the procedure, stage, grade and interval between H/S or SIS and laparotomy. Investigation into the rate...

Published: 08/13/2011

Archives of gynecology and obstetrics pmid:21837428

Uterine artery sparing robotic radical trachelectomy (AS-RRT) for early cancer of the cervix

Ahmed N Al-Niaimi, Margaret H Einstein, LaToya Perry, Ellen M Hartenbach, David M Kushner

CONCLUSION: Technically, the surgery is feasible and could be performed by any gynecologic oncologist who is skilled in radical pelvic surgery and the robotic system. The long-term obstetric and oncologic outcome of this technique would be expected to match the outcome of the other radical trachelectomy techniques in the published literature, but is yet to be fully elucidated.

Published: 10/16/2010

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics pmid:20947081

Effect of acetyl-l-carnitine on ovarian cancer cells' proliferation, nerve growth factor receptor (Trk-A and p75) expression, and the cytotoxic potential of paclitaxel and carboplatin

David B Engle, Jennifer A Belisle, Jennifer A A Gubbels, Sarah E Petrie, Paul R Hutson, David M Kushner, Manish S Patankar

CONCLUSION: ALCAR does not affect the cytotoxicity of paclitaxel or carboplatin. There was no increase in proliferation, or NGFR of OVCAR-3 or SKOV-3 cells exposed to ALCAR.

Published: 03/06/2009

Gynecologic oncology pmid:19263582

A protocol of dual prophylaxis for venous thromboembolism prevention in gynecologic cancer patients

M Heather Einstein, David M Kushner, Joseph P Connor, Alex A Bohl, Thomas J Best, Michael D Evans, Richard J Chappell, Ellen M Hartenbach

CONCLUSION: A protocol of dual prophylaxis with prolonged prophylaxis in high-risk patients was successfully implemented and was associated with a significant reduction in the rate of venous thromboembolism without increasing bleeding complications.

Published: 11/04/2008

Obstetrics and gynecology pmid:18978110

The effect of laparoscopic guidance on gynecologic interstitial brachytherapy

David B Engle, Kristin A Bradley, Rick J Chappell, Joseph P Conner, Ellen M Hartenbach, David M Kushner

CONCLUSION: The LAIB procedure appears safe, but substantially increases operating department time. No significant decrease in late high-grade toxicities were detected in comparison with TrIB. The LAIB procedure allows for both lysis of adhesions and identification of unknown carcinomatosis.

Published: 07/29/2008

Journal of minimally invasive gynecology pmid:18657479

Sonohysterography and endometrial cancer: incidence and functional viability of disseminated malignant cells

Emily Berry, Steven R Lindheim, Joseph P Connor, Ellen M Hartenbach, Julian C Schink, Josephine Harter, Jens C Eickhoff, David M Kushner

CONCLUSION: Transtubal spill occurs during sonohysterography. No critical spill volume was identified. A highly diagnostic tool when abnormal bleeding is evaluated, sonohysterography has a low probability of cancer cell dissemination.

Published: 05/06/2008

American journal of obstetrics and gynecology pmid:18456240

Laparoscopic sentinel lymph node mapping for cervix cancer--a detailed evaluation and time analysis

David M Kushner, Joseph P Connor, Michael A Wilson, G Reza Hafez, Richard J Chappell, Sarah L Stewart, Ellen M Hartenbach

CONCLUSIONS: Laparoscopic SLN mapping can be newly introduced into gynecologic oncology centers with high detection rates and negative predictive values. The visualization of blue dye in SLNs is transient, and this negative time correlation may explain the previously reported inferior detection rates with this technique. CLINICAL TRIAL REGISTRATION.: ClinicalTrials.gov, http://www.clinicaltrials.gov, NCT 00205010.

Published: 06/15/2007

Gynecologic oncology pmid:17560635

Weekly docetaxel and carboplatin for recurrent ovarian and peritoneal cancer: a phase II trial

David M Kushner, Joseph P Connor, Federico Sanchez, Michael Volk, Julian C Schink, Howard H Bailey, Linda S Harris, Sarah L Stewart, Jason Fine, Ellen M Hartenbach, Wisconsin Oncology Network

CONCLUSION: The weekly regimen of carboplatin and docetaxel has a good response rate with an acceptable toxicity profile.

Published: 01/30/2007

Gynecologic oncology pmid:17258800

Human telomerase RNA degradation by 2'-5'-linked oligoadenylate antisense chimeras in a cell-free system, cultured tumor cells, and murine xenograft models

Jayashree M Paranjape, Da Xu, David M Kushner, James Okicki, Daniel J Lindner, Hagen Cramer, Robert H Silverman, Douglas W Leaman

Ribonuclease L (RNase L) is a latent single-stranded RNA-directed endoribonuclease that is activated on binding to short 2'-5'-linked oligoadenylates (2-5A), a feature that has led to its use in antisense therapeutic strategies. By attaching a 2-5A moiety to the 5' terminus of standard antisense oligonucleotides, it is possible to activate RNase L and guide it to specific RNAs for degradation. These 2-5A antisense chimeras have been used successfully to target a variety of cellular and viral...

Published: 09/19/2006

Oligonucleotides pmid:16978086

Development and validation of a home-based, mirrored, gynecologic laparoscopy trainer

James K Robinson, David M Kushner

CONCLUSION: Home-based practice on a mirrored laparoscopy trainer improves hand-eye coordination in inexperienced surgeons and results in more frequent practice.

Published: 03/11/2006

Journal of minimally invasive gynecology pmid:16527711

Use of a bupivacaine continuous wound infusion system in gynecologic oncology: a randomized trial

David M Kushner, Regina LaGalbo, Joseph P Connor, Rick Chappell, Sarah L Stewart, Ellen M Hartenbach

CONCLUSION: The results suggest that although the continuous infusion system seems safe, it is not efficacious in this patient population.

Published: 08/02/2005

Obstetrics and gynecology pmid:16055569

Sonohysterography: a valuable tool in evaluating the female pelvis

Steven R Lindheim, Natalie Adsuar, David M Kushner, Elizabeth A Pritts, David L Olive

A number of medical conditions, including abnormal uterine bleeding, endometrial cancer, monitoring tamoxifen therapy, infertility, and recurrent abortion, warrant investigation of the female genital tract. Diagnostic studies including hysterosalpingogram, ultrasound, and sonohysterography have proved useful in the investigation of these gynecologic conditions. This article discusses each of these tests with particular emphasis on sonohysterography and their current and potential contributions...

Published: 10/29/2003

Obstetrical & gynecological survey pmid:14581828

Dr. Kushner's Research

Focus: Minimizing the negative impact of cancer and subsequent treatments on patients’ quality of life.

Kushner elected to Vice Chair of UW-Madison Biological Sciences committee

Congratulations to David Kushner, MD, professor in the Division of Gynecologic Oncology! Kushner was elected to serves as the 2024-25 Vice Chair of the UW–Madison Biological Sciences Division Committee, beginning July 1. After a year as vice chair, Kushner will become Chair of the committee for the 2025-26 academic year. 

The Biological Sciences Divisional Committee, the executive committee of the Faculty Division of Biological Sciences, is part of the Office of the Secretary of the Faculty’s Faculty Promotion and Review process. The Committee advises deans and directors about appointments and promotions to tenure and recommendations to use honorific modified professorial titles, names Hilldale Award recipients and Hilldale Lecture Series speakers, and makes appointments to standing and ad hoc committees. 

Congratulations on this well-deserved honor! 

Kushner publishes article in American Cancer Society Journal

David Kushner, MD, professor in the Division of Gynecologic Oncology, co-authored a new article published in American Cancer Society Journal. Co-authors include Narjust Florez, MD, Laurent Kiel, BS, Kelly Meza, MD, Zihan Wei, MS, Emanuele Mazzola, PhD, Ana I. Velazquex, MD, MSc, Idalid Franco, MD, MPH, Mary Jo Fidlr, MD, Ivy Elkins, Jill Feldman, Lori Seaborne, PA, Christine Heisler, MD, MS, Jennifer C. King, PhD, Amy Moore, PhD, Jacinta Wiens, PhD.

In “Sexual Health Assessment in Women with Lung Cancer study: Sexual health assessment in women with lung cancer”, Kushner and co-authors work to understand any correlations between lung cancer and sexual health. The study found that most women with stage IV lung cancer receiving targeted care felt little satisfaction in their sex lives.

“The most common reasons negatively affecting participants' satisfaction with their sex life included fatigue (40%) and feeling sad/unhappy (28%). Common reasons for lack of recent sexual activity included lack of interest (68%) and vaginal dryness or pain (30%). Compared to pre-diagnosis, women were significantly less likely to have recent interest in sexual activity. In multivariable logistic-regression, vaginal dryness showed a significant negative association with recent interest in sexual activity.”

Read the whole article here!

**by Paige Stevenson, Ob-Gyn Communications Intern

Kushner elected to UWSMPH Academic Planning Council

Congratulations to Dave Kushner, MD, professor in the Division of Gynecologic Oncology! Kushner was recently elected to a three-year term on the UW School of Medicine and Public Health’s Academic Planning Council (APC).

The APC advises the Dean’s Office on school programs and budgetary planning, including strategic and long-range planning for the SMPH, program review, and other key factors to help the school fulfill its academic mission.

Kushner will represent the Department of Ob-Gyn on this important council. Congratulations on this well-deserved honor, Dr. Kushner!

Kushner selected to serve on UW-Madison Biological Sciences Tenure Committee

Congratulations to David Kushner, MD, professor in the UW Ob-Gyn Division of Gynecologic Oncology! In this spring’s UW-Madison faculty committee elections, Kushner was selected to serve on the Biological Sciences Divisional Committee. His term on the committee begins in July 2023.

The Biological Sciences Divisional Committee, the executive committee of the Faculty Division of Biological Sciences, advises deans and directors about appointments and promotions to tenure and recommendations to use honorific modified professorial titles, names Hilldale Award recipients and Hilldale Lecture Series speakers, and makes appointments to standing and ad hoc committees.

Committee members serve three-year terms. Congratulations on this well-deserved honor!​

Obstetrics and Gynecology features video demonstration of fluorescein mapping for Paget’s Disease

In February, UW Ob-Gyn gynecologic oncology fellows Catherine Zhang, MD, MPH and Matt Wagar, MD, published a new Procedures and Instruments piece, “Fluorescein Mapping in Vulvar Paget Disease”, in Obstetrics and Gynecology. Co-authors on the article include Ryan Spencer, MD, MS, associate professor in the Division of Gynecologic Oncology, and David Kushner, MD, professor in the Division of Gynecologic Oncology.

In the article, Zhang, Wagar, and co-authors describe a two-step procedure to identify areas of disease when treating Paget disease, and describe their results using this method to treat eight patients. Obstetrics and Gynecology recently shared a case demonstration video of the technique on their YouTube channel.

You can watch the technique video here!

Zhang, Wagar publish in Obstetrics and Gynecology

UW Ob-Gyn gynecologic oncology fellows Catherine Zhang, MD, MPH and Matt Wagar, MD, published a new Procedures and Instruments piece in Obstetrics and Gynecology. Co-authors on the article include Ryan Spencer, MD, MS, associate professor in the Division of Gynecologic Oncology, and David Kushner, MD, professor in the Division of Gynecologic Oncology.

In “Fluorescein Mapping in Vulvar Paget Disease”, Zhang, Wagar, and co-authors describe a two-step procedure to identify areas of disease when treating Paget disease, and describe their results using this method to treat eight patients. Their conclusions are optimistic: 

“We report a technique for the injection of fluorescein sodium for the visualization of vulvar Paget disease capable of providing accurate surgical margins and identification of occult satellite lesions with a high degree of safety and a favorable cost profile. This staged approach to vulvectomy could offer improved accuracy of resection for vulvar Paget disease with few drawbacks.”

Read the whole article here!

Rash, Peterson, Sobecki, Kushner publish in Supportive Care in Cancer

​The UW Women’s Integrative Sexual Health (WISH) Clinic team of Joanne Rash, PA, Megan Peterson, DNP, Janelle Sobecki, MD, and David Kushner, MD published a new article in the journal Supportive Care in Cancer.

In “Patient reported improvement in sexual health outcomes following care in a sexual health clinic for women with cancer", Rash and co-authors aimed to determine the impact of interventions provided in the WISH Clinic. They found:

“Women with cancer report integrative sexual health care to address sexual health problems that are helpful and result in long-term improvement. Patients are overall highly adherent to recommended therapies, and nearly all would recommend the program to others."

Read the whole study here!

Sobecki appointed medical director of UW Health WISH Program

Janelle Sobecki, MD, MA, assistant professor in the Division of Gynecologic Oncology, recently stepped into the role of medical director for the UW Health Women’s Integrative Sexual Health (WISH) Program. Congratulations, Dr. Sobecki!

The WISH Program provides clinical consultation, resources, education, emotional support and appropriate referrals related to sexual health concerns for women with cancer. The program is open to people experiencing issues with gynecologic, breast, and other types of cancer. Sobecki became medical director on January 1, 2023.

David Kushner, MD, professor in the Division of Gynecologic Oncology, is the outgoing WISH medical director. Kushner developed the WISH program at UW Health and led it through many years of growth. His vision, expertise and leadership have improved the cancer survivorship experience for countless patients in our area.

Our thanks to Dr. Kushner for his many years of leadership, and huge congratulations to Dr. Sobecki on this new role!

Kushner to become Vice Chair of Faculty Development, Education and Wellness

David Kushner, MD, Professor in the Division of Gynecologic Oncology, has accepted the appointment of Vice Chair of Faculty Development, Education and Wellness. This appointment will be effective November 1, 2022!

As Vice Chair of Faculty Development, Education and Wellness, Kushner will be integrally involved with the department’s faculty mentoring program, recruitment, faculty promotions and supporting career development for faculty at all levels. Provider wellness is a new addition to this vice chair role and will include providing strategic vision and direction to the development, implementation, and evaluation of wellbeing initiatives, in collaboration with the department, UW SMPH, and UW Health leadership. He will also provide oversight and leadership for all levels of education in our department, working closely with the leaders of medical student, residency, fellowship, and graduate training programs to ensure the highest quality for all our educational programs.

Kushner brings a depth of experience to each aspect of this role. He has been a mentor to many early-career faculty, chairing and serving on countless faculty mentor committees as well as advising and mentoring medical students, residents, and fellows. He has long been a champion for wellbeing efforts, including founding and co-chairing the Society of Gynecologic Oncology Wellness Task Force, pioneering the Department of Ob-Gyn’s Wellness Committee in 2018, and serving as an active voice on the UW Health Provider Wellbeing Committee since its creation. He is an award-winning educator. During his tenure as director of the Division of Gynecologic Oncology, he successfully navigated the accreditation process to launch the UW Ob-Gyn Gynecologic Oncology fellowship, which he then led successfully for many years.

Thanks to Dr. Kushner for his leadership as Vice Chair of Research, a role he held since 2015, and congratulations on this new opportunity to shape the department’s faculty development, education, and wellness efforts!

Kushner published in Gynecologic Oncology

Dave Kushner, MD, professor in the UW Ob-Gyn Division of Gynecologic Oncology, is senior author on a new publication in the journal Gynecologic Oncology.

In “SGO and the elephant that is still in the room: Wellness, burnout and gynecologic oncology”, Kushner and co-authors analyzes survey responses from physician and advanced practice provider members of the Society of Gynecologic Oncology to compare mental health factors and burnout:

“Burnout in gynecologic oncology persists in both genders and is felt most acutely by female GOs. APPs are not immune and would benefit from inclusion in future research to mitigate burnout in healthcare clinicians.”

Read the whole study here!

SHAWL Study featured in World Conference on Lung Cancer media event

The Sexual Health Assessment in Women with Lung Cancer (SHAWL) study, co-authored by David Kushner, MD, professor in the UW Ob-Gyn Division of Gynecologic Oncology, was featured in a media event during the 2022 World Conference on Lung Cancer in August!

The SHAWL study overall found that 77% of participants experienced moderate to severe sexual dysfunction. During a media conference in Vienna, SHAWL study principal investigator Narjust Florez, MD (formerly of UW Carbone Cancer Center, now of Dana Farber Cancer Institute) outlined the key findings from the study:

“The take-home message is that sexual dysfunction is prevalent in women with lung cancer, that sexual health should be integrated into thoracic oncology care — “now, not tomorrow” — and that further research is necessary to develop tailored interventions for patients with lung cancer, Florez said.”

Read the whole article here!

Kushner published in International Journal of Obesity

Professor David Kushner, MD, of the Division of Gynecologic Oncology, is a co-author on a new study published in the International Journal of Obesity. 

In "Obesity and "obesity-related" cancers: Are there body mass index cut-points?", Kushner and co-authors used a retrospective cohort study to look for statistically significant associations between rising body mass index (BMI) and incidence of certain types of cancer:

“In adjusted logistic regression analyses, statistically significant associations were identified between increasing BMI and the incidence of kidney, thyroid, and uterine cancer. BMI cut-points were identified for kidney (26.3 kg/m2) and uterine (26.9 kg/m2) cancer.”

Read the whole study here.

Montemorano presenting at UW Resident and Fellow Quality Improvement and Patient Safety Symposium

On Thursday, May 26, UW Ob-Gyn gynecologic oncology fellow Lauren Montemorano, MD will present at the UW Resident and Fellow Quality Improvement and Patient Safety Symposium!

Montemorano will present “Code status documentation for admitted gynecologic oncology patients”, a project mentored by David Kushner, MD, of the UW Ob-Gyn Division of Gynecologic Oncology.

Incredible work, Dr. Montemorano!

Grand Rounds: Badger Bytes presentations on UW Ob-Gyn and Sexual Health Research

On May 12, 2022, several presenters shared updates on sexual health research and resources in the UW Department of Ob-Gyn during the Badger Bytes Grand Rounds presentation “UW Ob-Gyn and Sexual Health Research”.

The six presentations were:

Sex Therapy: Understanding Its Utility in Improving Patient Outcomes (presented by Madelyn Esposito-Smith, LPC)

Choosing the Right Vaginal Moisturizer and Lubricants for Your Patients (presented by Jon Pennycuff, MD, MSPH)

DaneMAC Mobile Forensic Nurse Exams – University Health Services (presented by Mary Landry, MD)

Cancer and Sexual Health: Clinical Need and Outcome Measures (presented by Joanne Rash, PA-C)

Cancer and Sexual Health: Collaborative Academic Partnership (presented by Janelle Sobecki, MD)

Cancer and Sexual Health: Setting Standards and Generating Evidence (presented by David Kushner, MD)

Watch the whole Badger Bytes presentation here!

Wang published in Gynecologic Oncology Reports

Congratulations to UW Ob-Gyn resident Connor Wang, MD, PGY-3, who is lead author on a new publication in Gynecologic Oncology Reports!

In the article “When we open and close: postoperative outcomes after aborted primary cytoreduction for ovarian cancer”, Wang and co-authors Matt Wagar, MD, PGY-4, Amy Godecker, PhD, Ahmed Al-Niaimi, MD, and David Kushner, MD aimed to expand available data to help counsel patients about outcomes after aborted primary debulking surgery.

This retrospective study looked at postsurgical morbidity for 43 patients who underwent aborted primary debulking surgery for advanced ovarian cancer:

“All patients subsequently underwent ICS, [interval cytoreductive surgery] with 21 (48.8%) achieving no residual macroscopic disease and 21 (48.8%) to ≤1cm of macroscopic disease. After AD [aborted primary debulking], 16 (37.2%) experienced at least one G≥3 event within the first 30 days. The most common complication was gastrointestinal complications. Preoperative albumin was the only significant predictor for G≥3 complication after AD.”

Read the whole study here!

UW Ob-Gyn presentations at 2022 Society of Gynecologic Oncology conference

Members of the UW Ob-Gyn Division of Gynecologic Oncology, fellows and residents prepared an impressive slate of posters and presentations for the 2022 Society of Gynecologic Oncology Annual Meeting on Women’s Cancer! Take a look at just some of the research brought to the hybrid conference, as well as the variety of service and leadership roles held by members of our department:

Ahmed Al-Niaimi, MD:

Master Class: Optimize and Operate: Enhancing Perioperative Quality, Safety, Experience, and Outcomes

Master Class: Debulk and Deliver: A Virtual Live-Streamed Master Class with Optional Hands-On Cytoreductive Surgery Lab 

Oral Plenary Presentation: Mechanical bowel preparation and post-operative renal dysfunction in patients undergoing cytoreductive surgery for ovarian cancer

Lisa Barroilhet, MD, MS:

Distillation: On-Demand Oral Featured Posters: Novel Therapies, PROs, and Disparities in Care

Special Interest Session: Curriculum for Emerging Clinical Trialists (Dr. Barroilhet is course director for this session)

Vice-Chair of the Patient Education Committee

Katherine Dryer, MD:

Poster: Outpatient palliative care utilization and aggressiveness of end-of-life care in women with gynecologic cancers (authors Kathryn Dryer MD, Janelle Sobecki MD, Michael Lasarev MS, Lena Law BA, Anna Stecher MD, Ellen Hartenbach MD)

Maya Gross, MD, MPH:

Poster: Risk factors associated with distress among postoperative patients in an academic gynecologic oncology practice

Ellen Hartenbach, MD:

Symposium: Wake to Wellness: Beating Burnout Through Better Patient Communication (Hartenbach presented “Mitigating Burnout Through Effective Communication Techniques”)

Palliative Medicine Committee 

Clinical Practice Committee

David Kushner, MD:

Finance Committee

Wellness Committee (Chair)

Developed two “Wake to Wellness” Sessions based on SGO Wellness Curriculum that was just published:

Managing Priorities 

Moving from Surviving to Thriving (Kushner will present as part of this session)

Senior author on Surgical Innovation presentation “Beneath the Surface: Fluorescein mapping in vulvar Paget’s Disease” given by Gyn Onc fellow Catherine Zhang, MD

Joanne Rash, PA:

Attending the SGO Board meeting (virtually), and will start her board term as the first-ever APP representative on the SGO board

Stephen Rose, MD:

Co-Chair of the Fellowship Program Directors Network and will be leading the annual meeting Thursday night. 

Hosting the UW Fellow Alumni Reception Sunday night

Senior author on Connor Wang’s study: Adaptive and maladaptive humor styles are closely associated with burnout and professional fulfillment in members of the Society of Gynecologic Oncology

Shannon Rush, MD:

Poster: Hormone replacement therapy counseling at prophylactic bilateral salpingo-oophorectomy in high risk patients

Janelle Sobecki, MD:

Poster: Risk factors associated with distress among postoperative patients in an academic gynecologic oncology practice (Maya Gross, Sumer Wallace - Senior)

Poster: Outpatient Palliative Care Utilization and Aggressiveness of End-of-Life Care in Women with Gynecologic Cancers (Kathryn Dryer, Ellen Hartenbach – Senior)

Sumer Wallace, MD:

Serves on Policy, Quality, & Outcomes task force for the Health Policy and Socioeconomic committee

Connor Wang, MD:

Poster: Adaptive and maladaptive humor styles are closely associated with burnout and professional fulfillment in members of the Society of Gynecologic Oncology

Catherine Zhang, MD:

Poster: Thromboembolic events in gynecologic cancer patients treated with chemotherapy (authors R. Zhang, MD; T. Stewart, BS; K. Tetreault, MS; R. Alexandridis, PhD; J. Bergsbaken, PharmD;  S. Wallace, MD; D. Kushner, MD;E. Hartenbach, MD)

Farr Nezhat Session Surgical Innovation Session: How Surgical Futurists are Revolutionizing Cancer Care (Zhang presented “Beneath the Surface: Fluorescein mapping in vulvar Paget’s Disease”)

Congratulations to all for these incredible achievements!

WISH Clinic team publishes article in Journal of the Advanced Practitioner in Oncology

A new article co-authored by Joanne Rash, PA-C, Megan Peterson, DNP, Janelle Sobecki, MD, and David Kushner, MD was published in the Journal of the Advanced Practitioner in Oncology!

Development, Implementation, and Patient Perspectives of the Women’s Integrative Sexual Health Program: A Program Designed to Address the Sexual Side Effects of Cancer Treatment” outlines the creation of the UW Carbone Cancer Center’s Women’s Integrative Sexual Health Clinic, which was created in 2013 by Rash and Lori Seabourne, PA-C. The publication also shares results from a patient experience survey:

“When asked how helpful their experience in the WISH program was, 99 of 113 (88%) reported that it was at least somewhat helpful. Seventy-five out of 110 (68%) said their experience in the WISH program improved their overall sexual function. Eighty out of 112 (71%) thought their sexual function would be worse if they had not been seen in the WISH program. Almost all (95%) reported they would recommend the WISH program to other women.”

Read the whole publication here. Congratulations to the WISH team!

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