Department of
Obstetrics and Gynecology

UNIVERSITY OF WISCONSIN–MADISON
SCHOOL OF MEDICINE AND PUBLIC HEALTH

Role Of Endogenous AhR Ligand In Pregnancy

09/01/2019 - 08/31/2020

Sponsor: UL1TR002373 (NCATS/NIH)

Status: Ongoing

The goal of this project is to determine the role of AhR ligands in vascular development and function during pregnancy.

Publications:

Li Y, Wang K, Zou QY, Zhou C, Magness RR, Zheng J. A possible role of aryl hydrocarbon receptor in preterm birth. Med Hypotheses. 2015; 84:494-497. PMC4380652.

Li Y, Wang K, Zou QY, Magness RR, Zheng J. 2,3,7,8-Tetrachlorodibenzo-p-dioxin differentially suppresses angiogenic responses in human placental vein and artery endothelial cells. Toxicology 2015; 336:70-78. PMC4593512.

Wu YM, Chen X, Liu CH, Bao S, He QZ, Zhou Q, Li Y, Zheng J, Duan T, Wang K. Potential involvement of placental AhR in unexplained recurrent spontaneous abortion. Reprod Toxicol 2016; 59: 45-52.

Li Y, Wang K, Zou QY, Jiang YZ, Zhou C, Zheng J. An endogenous aryl hydrocarbon receptor ligand suppresses angiogenic responses of human artery and vein endothelial cells: differential roles of AhR. Reprod Toxicol 2017; 74:181-188. PMC5718942.

Pang LP, Li Y, Zou QY, Zhou C, Lei W, Zheng J*, Huang SA*. ITE inhibits proliferation of pulmonary artery endothelial cells independent of AhR. Exp Lung Res 2017; 43:283-292.*Co-correspondence. PMC5909382

Zhu KX, Meng Q, Zhang Z, He Y, Zheng J, Lei W. Aryl hydrocarbon receptor pathway: role, regulation, and intervention in atherosclerosis therapy. Mol Med Rep. 2019; 20(6):4763-4773.