Department of
Obstetrics and Gynecology

UNIVERSITY OF WISCONSIN–MADISON
SCHOOL OF MEDICINE AND PUBLIC HEALTH

The Role Of MiRNAs In Placental Vascular Function

Status: Ongoing

The goal of this project is to determine the role of miRNAs in controlling fetoplacental vascular function.

Publications:

Zhou C, Zou QY, Li H, Liu AX, Wang RF, Magness RR, Zheng J. Preeclampsia down-regulates microRNAs in fetal endothelial cells: Roles of miR-29a/c-3p in endothelial function. J Clin Endocrinol Metab 2017; 102: 3470-3479. PMC5587062.

Zhou C, Yan Q, Zou QY, Zhong XQ, Tyler CT, Magness RR, Bird IM, Zheng J. Sexual dimorphism of preeclampsia-dysregulated transcriptomic profiles and cellular function in fetal endothelial cells. Hypertension 2019;74(1):154-163. [An invited editorial commentary by Reckelhoff JF et al appeared in Hypertension DOI:10.1161/HYPERTENSIONAHA.119.12652), stating that this study “determine whether fetal sex alters HUVEC function and to provide insight into potential mechanism responsible for sex differences in increased cardiovascular risk in offspring of pregnancies complicated by preeclampsia”. They also emphasized the need for further investigation of this important work.). PMC6561818.