Protrait

 

Lisa Barroilhet, MD, MS
Associate Professor (CHS)
Doloroes Buchler Endowed Professor


Gynecologic Oncology
UW Health


Office Address
UW Hospital and Clinics, Room: H4/638
600 Highland Ave
Madison, WI, 53705


Clinic Address
Gynecology Oncology Clinic
600 Highland Ave
Madison, WI, 53705
Phone: 608-265-1700


Administrative Assistant
Tahnee Snellings
tsnellings@wisc.edu
608-262-2262



Hospital Profile

Bio

Dr. Barroilhet is an Associate Professor in the department of Obstetrics and Gynecology at the University of Wisconsin School of Medicine and Public Health. She completed her four-year residency in obstetrics and gynecology at University of North Carolina-Chapel Hill. After finishing her residency in 2009, she completed her three-year clinical and research fellowship in gynecologic oncology at Brigham and Women's Hospital in Boston, Massachusetts. Dr. Barroilhet joined the University of Wisconsin Department of Obstetrics and Gynecology in 2012. She has been the recipient of the NCI Clinical Care Team Leadership Award and is currently a GOG Scholar Investigator. Most recently she has been funded by the Reproductive Science Development Program and the NCI, where she has an R01 award entitled Repurposing Atovaquone for the Prevention of Ovarian Cancer. Her primary research interests focus on prevention and early detection of ovarian cancer in a high-risk population. Dr. Barroilhet has published in numerous peer-reviewed journals and has been active in presenting research at national conferences. She has been recognized with multiple awards by her peers for exemplary teaching of residents and staff as well as patient care.


Education

MS Clinical Investigation, University of Wisconsin - Madison , Madison, WI

BS Duke University, Durham, NC

MD University of Minnesota, Minneapolis, MN

Residency University of North Carolina, Chapel Hill, NC

Fellowship Brigham and Women's Hospital, Boston, MA


Certifications

Diplomate, American Board of Obstetrics and Gynecology


Honors and Awards

UW Health Patient Experience Provider Champion Award

UW Department of Ob-Gyn John M. Anderson Award

UW Health Patient Experience Physician Champion Award

UW Health Physician Excellence Nominee

“Top Doctors”: Gynecologic Oncology,
Madison Magazine, Madison, WI


Memberships

NRG Oncology Group

Society of Gynecologic Oncology 

National Comprehensive Cancer Network

American Board of Obstetricians and Gynecologists

American Society of Clinical Oncologists

 

Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology

Deborah K Armstrong, Ronald D Alvarez, Jamie N Bakkum-Gamez, Lisa Barroilhet, Kian Behbakht, Andrew Berchuck, Lee-May Chen, Mihaela Cristea, Maria DeRosa, Eric L Eisenhauer, David M Gershenson, Heidi J Gray, Rachel Grisham, Ardeshir Hakam, Angela Jain, Amer Karam, Gottfried E Konecny, Charles A Leath, Joyce Liu, Haider Mahdi, Lainie Martin, Daniela Matei, Michael McHale, Karen McLean, David S Miller, David M O'Malley, Sanja Percac-Lima, Elena Ratner, Steven W Remmenga, Roberto Vargas, Theresa L Werner, Emese Zsiros, Jennifer L Burns, Anita M Engh

Published Date: February, 2021 - pmid:33545690 - Journal of the National Comprehensive Cancer Network : JNCCN


Oxidative stress induced by the anti-cancer agents, plumbagin, and atovaquone, inhibits ion transport through Na+/K+-ATPase

Yousef Alharbi, Arvinder Kapur, Mildred Felder, Lisa Barroilhet, Bikash R Pattnaik, Manish S Patankar

Published Date: November, 2020 - pmid:33177587 - Scientific reports


Berzosertib plus gemcitabine versus gemcitabine alone in platinum-resistant high-grade serous ovarian cancer: a multicentre, open-label, randomised, phase 2 trial

Panagiotis A Konstantinopoulos, Su-Chun Cheng, Andrea E Wahner Hendrickson, Richard T Penson, Susan T Schumer, L Austin Doyle, Elizabeth K Lee, Elise C Kohn, Linda R Duska, Marta A Crispens, Alexander B Olawaiye, Ira S Winer, Lisa M Barroilhet, Siqing Fu, Michael T McHale, Russell J Schilder, Anniina Färkkilä, Dipanjan Chowdhury, Jennifer Curtis, Roxanne S Quinn, Brittany Bowes, Alan D D'Andrea, Geoffrey I Shapiro, Ursula A Matulonis

Published Date: June, 2020 - pmid:32553118 - The Lancet. Oncology


Identification of unique clusters of T, dendritic, and innate lymphoid cells in the peritoneal fluid of ovarian cancer patients

Jessica Vazquez, Melina Chavarria, Gladys E Lopez, Mildred A Felder, Arvinder Kapur, Antonio Romo Chavez, Nathan Karst, Lisa Barroilhet, Manish S Patankar, Aleksandar K Stanic

Published Date: June, 2020 - pmid:32524661 - American journal of reproductive immunology (New York, N.Y. : 1989)


A randomized phase II evaluation of weekly gemcitabine plus pazopanib versus weekly gemcitabine alone in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma

L R Duska, G R Petroni, N Varhegyi, J Brown, D Jelovac, K N Moore, W P McGuire, C Darus, L M Barroilhet, A A Secord

Published Date: April, 2020 - pmid:32247603 - Gynecologic oncology


Comparison of International Ovarian Tumor Analysis Simple Rules to Society of Radiologists in Ultrasound Guidelines for Detection of Malignancy in Adnexal Cysts

Krupa K Patel-Lippmann, Elizabeth A Sadowski, Jessica B Robbins, Viktoriya Paroder, Lisa Barroilhet, Elizabeth Maddox, Timothy McMahon, Emmanuel Sampene, Ashish P Wasnik, Alexander D Blaty, Katherine E Maturen

Published Date: November, 2019 - pmid:31770022 - AJR. American journal of roentgenology


Anti-programmed Death-1 Immunotherapy for Endometrial Cancer with Microsatellite Instability-High Tumors

Janelle Sobecki-Rausch, Lisa Barroilhet

Published Date: November, 2019 - pmid:31754884 - Current treatment options in oncology


Plumbagin-induced oxidative stress leads to inhibition of Na+/K+-ATPase (NKA) in canine cancer cells

Yousef Alharbi, Arvinder Kapur, Mildred Felder, Lisa Barroilhet, Timothy Stein, Bikash R Pattnaik, Manish S Patankar

Published Date: August, 2019 - pmid:31391478 - Scientific reports


NCCN Guidelines Insights: Ovarian Cancer, Version 1.2019

Deborah K Armstrong, Ronald D Alvarez, Jamie N Bakkum-Gamez, Lisa Barroilhet, Kian Behbakht, Andrew Berchuck, Jonathan S Berek, Lee-May Chen, Mihaela Cristea, Marie DeRosa, Adam C ElNaggar, David M Gershenson, Heidi J Gray, Ardeshir Hakam, Angela Jain, Carolyn Johnston, Charles A Leath, Joyce Liu, Haider Mahdi, Daniela Matei, Michael McHale, Karen McLean, David M O'Malley, Richard T Penson, Sanja Percac-Lima, Elena Ratner, Steven W Remmenga, Paul Sabbatini, Theresa L Werner, Emese Zsiros, Jennifer L Burns, Anita M Engh

Published Date: August, 2019 - pmid:31390583 - Journal of the National Comprehensive Cancer Network : JNCCN


BRCA Mutation Carriers: Breast and Ovarian Cancer Screening Guidelines and Imaging Considerations

Mai Elezaby, Brittany Lees, Katherine E Maturen, Lisa Barroilhet, Kari B Wisinski, Sarina Schrager, Lee G Wilke, Elizabeth Sadowski

Published Date: May, 2019 - pmid:31038410 - Radiology


Paternal uniparental isodisomy of tyrosine hydroxylase locus at chromosome 11p15.4: spectrum of phenotypical presentations simulating hydatidiform moles

Natalia Buza, Stephanie M McGregor, Lisa Barroilhet, Xingzheng Zheng, Pei Hui

Published Date: April, 2019 - pmid:30952972 - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc


Using simple radiologic measurements to anticipate surgical challenge in endometrial cancer: a prospective study

Ross F Harrison, Jeremiah E Mcnamara, Claire B Beaumont, Elizabeth A Sadowski, Richard J Chappell, Mian M Shahzad, Ryan J Spencer, Ahmed N Al-Niaimi, Lisa M Barroilhet, Stephen L Rose, David M Kushner

Published Date: January, 2019 - pmid:30640690 - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society


Neoadjuvant chemotherapy is associated with a high rate of perioperative blood transfusion at the time of interval cytoreductive surgery

Kevin W McCool, Emmanuel Sampene, Brock Polnaszek, Joseph Connor, Erin E Medlin, Lisa Barroilhet

Published Date: October, 2018 - pmid:30367632 - BMC cancer


Oxidative Phosphorylation: A Target for Novel Therapeutic Strategies Against Ovarian Cancer

Amruta P Nayak, Arvinder Kapur, Lisa Barroilhet, Manish S Patankar

Published Date: September, 2018 - pmid:30231564 - Cancers


Peri-operative allogeneic blood transfusion is associated with poor overall survival in advanced epithelial ovarian Cancer; potential impact of patient blood management on Cancer outcomes

Joseph P Connor, Andrea O'Shea, Kevin McCool, Emmanuel Sampene, Lisa M Barroilhet

Published Date: September, 2018 - pmid:30201233 - Gynecologic oncology


Dr. Barroilhet's Research Focus

Dr. Barroilhet's laboratory works on ovarian cancer prevention and early detection. Other projects include novel imaging techniques and identifying circulating biomarkers.


Gyn Onc reunion at NRG2020 in Houston

National conferences are a great way to stay connected to the latest developments in our fields, and the January 2020 NRG Oncology Semiannual Meeting is no different. But in addition to catching up on PARP inhibitors and kicking off new clinical trial protocols, this year’s meeting also offers an opportunity to catch up with old friends!

UW Ob-Gyn Division of Gynecologic Oncology faculty Lisa Barroilhet, MD and Ellen Hartenbach, MD, UW Gyn Onc fellow Janelle Sobecki-Rausch, MD, and residency graduates/current MD Anderson gynecologic oncology fellows Ross Harrison, MD and Han Cun, MD met up for what looks like a lively dinner! Love to see a UW Ob-Gyn reunion.  


Barroilhet earns Reproductive Scientist Development Program award!

Our sincere congratulations to Lisa Barroilhet, MD, of the UW Ob-Gyn Division of Gynecologic Oncology! Barroilhet earned a Reproductive Scientist Development Program (RSDP) awardsupported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health.

The RSDP provides career development support for obstetricians and gynecologists who are committed to a basic science career in academic medicine and research. The grant supports significant protected research time over two to three years.

Amazing work, Dr. Barroilhet!


Barroilhet helps rewrite health history of area family in story from UW Health

recent story from UW Health highlights how Lisa Barroilhet, MD, of the UW Ob-Gyn Division of Gynecologic Oncology, helped a Wisconsin family better understand their health history and overall risk of BRCA-related cancers.

After a UW Health patient was diagnosed with stage one ovarian cancer, Barroilhet recommended she meet with genetic counselors at the UW Carbone Cancer Center. Thanks to Barroilhet’s recommendation, the family was able to map out connections between previous generations’ cancer diagnoses, and share the suggestion for genetic counseling with other family members who might be at risk.

Read the whole article here!


UW Ob-Gyn gyn onc faculty to present at OncLive State of the Science Summit – May 12

Learn about the latest in ovarian cancer care and treatment from the UW Ob-Gyn Division of Gynecologic Oncology at the OncLive State of the Science Summit on May 12, 2020. It’s free to attend this event at the Sheraton Madison Hotel, 5-9pm!

Gynecologic Oncology Division Director Stephen Rose, MD is program chair for the event. Speakers include Ahmed Al-Niaimi, MD, Lisa Barroilhet, MD, Ellen Hartenbach, MD, Ryan Spencer, MD and Sumer Wallace, MDThey’ll cover topics like molecular testing, surgical options, PARP inhibitors, immunotherapy and more in the treatment and management of ovarian cancer.

More information available on this flyer (PDF). You can register to attend this free event here!


Barroilhet awarded R01 grant!

Congratulations to Lisa Barroilhet, MD, of the UW Ob-Gyn Division of Gynecologic Oncology! Barroilet has been awarded her first Research Project Grant (R01) from the National Institutes of Health for the project "Repurposing Atovaquone for the Prevention of Ovarian Cancer."

This five-year award includes an innovative mouse model and a clinical trial on the effects of atovaquone on normal ovarian and fallopian tube tissue. Division of Reproductive Sciences Director Manish Patankar, PhD and Arvinder Kapur, PhD, were instrumental in the successful submission of this grant and will continue to be close collaborators.

Please congratulate Dr. Barroilhet, as well as Dr. Patankar and Dr. Kapur on this incredible accomplishment!


Women’s Healthcast: Clinical Safety and COVID-19

Our healthcare system mounted a rapid response to the COVID-19 pandemic in early 2020, which included pausing or delaying some non-essential or elective care, ramping up telehealth or video visits, and limiting in-person appointments for patient safety. Now, in Wisconsin, we’re getting ready to loosen some restrictions and bring people back into clinics.

On this episode, three doctors in the UW-Madison Department of Ob-Gyn discuss safety precautions and changes to prenatal, obstetrical, general women’s health, and gynecologic cancer care, as well as what’s happening the clinical research world. Thanks to Division of Academic Specialists in Ob-Gyn Director Makeba Williams, MD, gynecologic oncologist Lisa Barroilhet, MD, and Vice Chair for Clinical Research David Kushner, MD for providing an update on clinical and research safety at UW Health.

Listen to Is it Safe to See the Doctor? Clinical Safety and COVID-19 now.

Did you know the Women’s Healthcast is available on all your favorite podcast platforms? Whether you like to listen on iTunesSpotifyGoogle PlayStitcherPodbean, or anywhere else, you can find us! (Just search Women’s Healthcast, and while you’re at it, may as well subscribe!)


Barroilhet publishes in Gynecologic Oncology

Lisa Barroilhet, MD, of the UW Ob-Gyn Division of Gynecologic Oncology, co-authored an article published in the June 2020 edition of Gynecologic Oncology!

A randomized phase II evaluation of weekly gemcitabine plus pazopanib versus weekly gemcitabine alone in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma” shares data collected from an open-label, randomized, multi-site, phase 2 trial comparing two different modes of treatment for cancer. Patients were randomly assigned to receive only gemcitabine, or to receive gemcitabine plus pazopanib.

Researchers found:

“The addition of paz to gem enhanced anti-tumor activity; those with platinum-resistant disease derived the most benefit from combination therapy, even in the setting of receiving prior bevacizumab.”

Read the whole article here!


Patankar and Stanic labs publish in American Journal of Reproductive Immunology

An article in the American Journal of Reproductive Immunology was co-authored by researchers in the UW Ob-Gyn Divisions of Reproductive Sciences and Gynecologic Oncology! 

Identification of unique clusters of T, dendritic, and innate lymphoid cells in the peritoneal fluid of ovarian cancer patients” is a collaboration between members of the Patankar Lab and Stanic Lab, with clinical collaborators in the Division of Gynecologic Oncology. Co-authors include Division of Reproductive Sciences Director Manish Patankar, PhD, Aleks Stanic-Kostic, MD, PhD, Stanic Lab postdoctoral fellow Jessica Vazquez, PhD, Patankar Lab assistant scientist Arvinder Kapur, PhD, gynecologic oncologist Lisa Barroilhet, MD, and recently graduated resident Antonio Romo de Vivar Chavez, MD.

This work focuses on determination of the immune compartment in ovarian cancer ascites, an understudied but extremely important site for immune control of cancer spread. For the study, the Stanic Lab used their advanced immune monitoring platform using high-dimensional flow cytometry to examine the immunome of ascites specimens isolated, processed, characterized and cryopreserved by the Patankar Lab. Researchers identified novel immune cell clusters and demonstrated their association with pre-surgery CA-125 level, hinting at modulation of subsequent survival.

This work forms the basis of several projects and grant applications from Patankar and Stanic Labs and exemplifies the collaborative spirit of the Divisions of Reproductive Sciences and Gynecologic Oncology. 

Read the whole article here – congratulations to all co-authors!


Grand Rounds: Barroilhet presents “Blood Product Utilization in Obstetrics and Gynecology: When Less is More”

On July 16, 2020, Lisa Barroilhet, MD, of the UW Ob-Gyn Division of Gynecologic Oncology presented the Grand Rounds lecture “Blood Product Utilization in Obstetrics and Gynecology: When Less is More.”

In her presentation, Barroilhet reviewed rationale behind restrictive use of blood products, discussed cancer-specific mortality as it relates to blood transfusion, and gave an overview of research happening in the Division of Gynecologic Oncology involving iron infusions to reduce peri-operative transfusions for ovarian cancer patients.

Watch the whole lecture here.


Barroilhet named first-ever Dolores A. Buchler, MD, Professor in Gynecologic Oncology

A special congratulations to Lisa Barroilhet, MD, of the UW Ob-Gyn Division of Gynecologic Oncology, as she is officially appointed the first Dolores A. Buchler, MD Professor of Gynecologic Oncology. 

It is only once or twice a lifetime that you come across a doctor like Dolores “Dee” Buchler. 

Dee joined the University of Wisconsin in 1969 after finishing her residency at University of Kansas where she trained in Ob-Gyn and the emerging fields of gynecologic oncology and radiation oncology—an extremely rare combination, and especially notable for a woman at that time.  Her prowess in radiation techniques and her unparalleled surgical skills combined were truly a rare commodity.  She was a pioneer in the treatment of gynecologic malignancies and a true innovator in the field, developing techniques for women’s cancers which now serve as the national model. 

Dee also was a leader in the department, beloved by learners, patients and colleagues alike. Dr. Buchler retired in 1995 as a professor in both Obstetrics and Gynecology and Human Oncology, leaving behind a legacy of impactful education, innovation, and care. 

In 2015, Dee established the Dolores Buchler Faculty Fellowship of Gynecologic Oncology to support a young surgeon with a passion for research and educating a new generation of doctors.  This year, Dee doubled down on her legacy by transforming her Fellowship to a Professorship, taking advantage of a unique match opportunity provided by John and Tashia Morgridge.

We are thrilled to add Dr. Lisa Barroilhet, the Dolores A. Buchler Professor of Gynecologic Oncology, to our growing list of endowed professors in Obstetrics and Gynecology. The funding provided by Dr. Buchler will protect Dr. Barroilhet’s time and provide discretionary funding to advance her research.

Dr. Buchler’s generosity and vision continue to inspire our department and work, and we will be forever grateful as her professorship moves the needle on women’s cancers forever. 

To learn more about professorships and endowed funds to support Ob-Gyn research, faculty, and training, contact Lily Johnson at 608-354-4918 or lily.johnson@supportuw.org


First HAGO Conference was a great success!

On September 10-11, the UW Ob-Gyn Division of Gynecologic Oncology hosted the first-ever Heartland Association of Gynecologic Oncology (HAGO) meeting. More than 70 gynecologic oncology professionals tuned in for the virtual conference, which included two keynote presentations and 21 research abstract presentations.

HAGO was founded in 2020 by UW Ob-Gyn Division of Gyn Onc Director Stephen Rose, MD, and the program committee included Ryan Spencer, MD and UW Ob-Gyn Gyn Onc fellowship graduates Andrea O’Shea, MD and Shitanshu Uppal, MD.

Of the 21 abstracts selected for presentation, five were from our department (Matthew Wagar, MD with mentor Sumer Wallace, MDWagar with mentor Makeba Williams, MDShannon Rush, MD with mentor Steve Rose, MDRachel Mojdehbakhsh, MD with mentor Ryan Spencer, MD; and Connor Wang, MD with mentor Spencer).

UW Ob-Gyn Gyn Onc fellow Shannon Rush, MD earned the first Award for Clinical Research for her abstract “65 Revisited: A Revised Markov Model for Evaluating Oophorectomy at the Time of Hysterectomy for Benign Disease”!

Lisa Barroilhet, MD was also an invited distillation presenter and UW Ob-Gyn Department Chair Laurel Rice, MD gave a keynote address and received the inaugural HAGO Award for Service and Leadership.

Our congratulations to everyone involved in planning and preparing the HAGO Conference – incredible work!


Grand Rounds: Badger Bytes on opioids and women’s health

 
On Thursday, January 7, a multidisciplinary group presented Badger Bytes Grand Rounds lectures as part of the presentation “The Multiple Dimensions of Opioid Use for Women’s Health.” The session was moderated by UW Ob-Gyn Division of Reproductive and Population Health Director Deborah Ehrenthal, MD, MPH.

Erin Nacev, MD/MPH student in the UW SMPH started off with “Prenatal Opioid Use Disorder and Birth Outcomes in Wisconsin". In her presentation, Nacev examined the prevalence of prenatal opioid use disorder and uptake of medication-assisted treatment among Medicaid-covered births in Wisconsin, and discussed future directions for research on OUD and pregnancy.

Next, UW Ob-Gyn resident Emily Buttigieg, MD, PGY-4 presented "Gynecologic Surgery Postoperative Narcotic Use". In the presentation, Buttigieg examined prescribing patterns for opioids after gynecologic surgery at a large academic medical center, and estimated ideal prescription size to reduce unused opioids after procedures.

Lisa Barroilhet, MD, of the UW Ob-Gyn Division of Gynecologic Oncology presented the last lecture “Opioids, Cancer and the Immune System: Untangling a Complicated Relationship". Barroilhet outlined some ways opioids affect cancer treatments, options for pain control while limiting opioids, and areas for further study.

Watch the whole Badger Bytes presentation here!